ID:USF1_HUMAN DESCRIPTION: RecName: Full=Upstream stimulatory factor 1; AltName: Full=Class B basic helix-loop-helix protein 11; Short=bHLHb11; AltName: Full=Major late transcription factor 1; FUNCTION: Transcription factor that binds to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3') that is found in a variety of viral and cellular promoters. SUBUNIT: Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a homodimer or a heterodimer (USF1/USF2). Interacts with varicella-zoster virus IE62 protein. INTERACTION: Q92831:KAT2B; NbExp=5; IntAct=EBI-1054489, EBI-477430; SUBCELLULAR LOCATION: Nucleus. DISEASE: Genetic variations in USF1 are associated with hyperlipidemia combined type 1 (HYPLIP1) [MIM:602491]; also known as familial combined hyperlipidemia type 1 (FCHL1). HYPLIP1 is characterized by elevated levels of serum total cholesterol, triglycerides or both, and is observed in about 20% of individuals with premature coronary heart disease. SIMILARITY: Contains 1 bHLH (basic helix-loop-helix) domain. WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/usf1/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P22415
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0003677 DNA binding GO:0003690 double-stranded DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding GO:0005515 protein binding GO:0019899 enzyme binding GO:0019901 protein kinase binding GO:0042802 identical protein binding GO:0042803 protein homodimerization activity GO:0042826 histone deacetylase binding GO:0043425 bHLH transcription factor binding GO:0043565 sequence-specific DNA binding GO:0046982 protein heterodimerization activity GO:0046983 protein dimerization activity
Biological Process: GO:0000430 regulation of transcription from RNA polymerase II promoter by glucose GO:0000432 positive regulation of transcription from RNA polymerase II promoter by glucose GO:0001666 response to hypoxia GO:0006006 glucose metabolic process GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0006366 transcription from RNA polymerase II promoter GO:0009411 response to UV GO:0019086 late viral transcription GO:0032869 cellular response to insulin stimulus GO:0042593 glucose homeostasis GO:0045893 positive regulation of transcription, DNA-templated GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0045990 carbon catabolite regulation of transcription GO:0051918 negative regulation of fibrinolysis GO:0055088 lipid homeostasis