Human Gene UQCRH (ENST00000311672.10_4) from GENCODE V47lift37
  Description: ubiquinol-cytochrome c reductase hinge protein, transcript variant 1 (from RefSeq NM_006004.4)
Gencode Transcript: ENST00000311672.10_4
Gencode Gene: ENSG00000173660.12_7
Transcript (Including UTRs)
   Position: hg19 chr1:46,769,370-46,782,448 Size: 13,079 Total Exon Count: 4 Strand: +
Coding Region
   Position: hg19 chr1:46,769,439-46,782,256 Size: 12,818 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:46,769,370-46,782,448)mRNA (may differ from genome)Protein (91 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedReactomeUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: QCR6_HUMAN
DESCRIPTION: RecName: Full=Cytochrome b-c1 complex subunit 6, mitochondrial; AltName: Full=Complex III subunit 6; AltName: Full=Complex III subunit VIII; AltName: Full=Cytochrome c1 non-heme 11 kDa protein; AltName: Full=Mitochondrial hinge protein; AltName: Full=Ubiquinol-cytochrome c reductase complex 11 kDa protein; Flags: Precursor;
FUNCTION: This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1.
SUBUNIT: The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1).
SUBCELLULAR LOCATION: Mitochondrion inner membrane.
SIMILARITY: Belongs to the UQCRH/QCR6 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 112.40 RPKM in Heart - Left Ventricle
Total median expression: 2070.93 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -16.1069-0.233 Picture PostScript Text
3' UTR -35.10192-0.183 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR003422 - Cyt_b-c1_6
IPR023184 - Ubol_cytC_Rdtase_hinge_dom

Pfam Domains:
PF02320 - Ubiquinol-cytochrome C reductase hinge protein

SCOP Domains:
103657 - BAR/IMD domain-like
81531 - Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)

ModBase Predicted Comparative 3D Structure on P07919
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologGenome BrowserNo ortholog
Gene DetailsGene Details Gene DetailsGene Details 
Gene SorterGene Sorter Gene SorterGene Sorter 
 RGDEnsembl WormBase 
    Protein Sequence 
    Alignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0008121 ubiquinol-cytochrome-c reductase activity

Biological Process:
GO:0006119 oxidative phosphorylation
GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c
GO:0009060 aerobic respiration
GO:0055114 oxidation-reduction process

Cellular Component:
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005746 mitochondrial respiratory chain
GO:0005750 mitochondrial respiratory chain complex III
GO:0016020 membrane
GO:0070469 respiratory chain


-  Descriptions from all associated GenBank mRNAs
  D28439 - Homo sapiens mRNA for ubiquinol-cytochrome c reductase 11kDa protein, 5'UTR region.
BC093060 - Homo sapiens ubiquinol-cytochrome c reductase hinge protein, mRNA (cDNA clone MGC:111145 IMAGE:30409772), complete cds.
BC001934 - Homo sapiens ubiquinol-cytochrome c reductase hinge protein, mRNA (cDNA clone MGC:4010 IMAGE:2823237), complete cds.
BC107703 - Homo sapiens ubiquinol-cytochrome c reductase hinge protein, mRNA (cDNA clone MGC:111572 IMAGE:6605146), complete cds.
BC015177 - Homo sapiens ubiquinol-cytochrome c reductase hinge protein, mRNA (cDNA clone MGC:10149 IMAGE:3905169), complete cds.
BC001426 - Homo sapiens ubiquinol-cytochrome c reductase hinge protein, mRNA (cDNA clone MGC:1361 IMAGE:3140323), complete cds.
AK311967 - Homo sapiens cDNA, FLJ92239, highly similar to Homo sapiens ubiquinol-cytochrome c reductase hinge protein (UQCRH), mRNA.
Y00764 - Human mRNA for mitochondrial hinge protein.
M36647 - Homo sapiens mitochondrial hinge protein precursor, mRNA, complete cds.
KJ892364 - Synthetic construct Homo sapiens clone ccsbBroadEn_01758 UQCRH gene, encodes complete protein.
BT007070 - Homo sapiens ubiquinol-cytochrome c reductase hinge protein mRNA, complete cds.

-  Biochemical and Signaling Pathways
  BioCyc Knowledge Library
PWY-3781 - aerobic respiration I (cytochrome c)

Reactome (by CSHL, EBI, and GO)

Protein P07919 (Reactome details) participates in the following event(s):

R-HSA-164651 Electron transfer from ubiquinol to cytochrome c of complex III
R-HSA-611105 Respiratory electron transport
R-HSA-163200 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
R-HSA-1428517 The citric acid (TCA) cycle and respiratory electron transport
R-HSA-1430728 Metabolism

-  Other Names for This Gene
  Alternate Gene Symbols: B2R4V9, D3DQ18, ENST00000311672.1, ENST00000311672.2, ENST00000311672.3, ENST00000311672.4, ENST00000311672.5, ENST00000311672.6, ENST00000311672.7, ENST00000311672.8, ENST00000311672.9, NM_006004, P07919, Q5TDF6, Q6LDB8, Q9BQ91, QCR6_HUMAN, uc317pbe.1, uc317pbe.2
UCSC ID: ENST00000311672.10_4
RefSeq Accession: NM_006004.4
Protein: P07919 (aka QCR6_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.