ID:QCR6_HUMAN DESCRIPTION: RecName: Full=Cytochrome b-c1 complex subunit 6, mitochondrial; AltName: Full=Complex III subunit 6; AltName: Full=Complex III subunit VIII; AltName: Full=Cytochrome c1 non-heme 11 kDa protein; AltName: Full=Mitochondrial hinge protein; AltName: Full=Ubiquinol-cytochrome c reductase complex 11 kDa protein; Flags: Precursor; FUNCTION: This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1. SUBUNIT: The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1). SUBCELLULAR LOCATION: Mitochondrion inner membrane. SIMILARITY: Belongs to the UQCRH/QCR6 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF02320 - Ubiquinol-cytochrome C reductase hinge protein
SCOP Domains: 103657 - BAR/IMD domain-like 81531 - Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)
ModBase Predicted Comparative 3D Structure on P07919
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005515 protein binding GO:0008121 ubiquinol-cytochrome-c reductase activity
Biological Process: GO:0006119 oxidative phosphorylation GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c GO:0009060 aerobic respiration GO:0055114 oxidation-reduction process
D28439 - Homo sapiens mRNA for ubiquinol-cytochrome c reductase 11kDa protein, 5'UTR region. BC093060 - Homo sapiens ubiquinol-cytochrome c reductase hinge protein, mRNA (cDNA clone MGC:111145 IMAGE:30409772), complete cds. BC001934 - Homo sapiens ubiquinol-cytochrome c reductase hinge protein, mRNA (cDNA clone MGC:4010 IMAGE:2823237), complete cds. BC107703 - Homo sapiens ubiquinol-cytochrome c reductase hinge protein, mRNA (cDNA clone MGC:111572 IMAGE:6605146), complete cds. BC015177 - Homo sapiens ubiquinol-cytochrome c reductase hinge protein, mRNA (cDNA clone MGC:10149 IMAGE:3905169), complete cds. BC001426 - Homo sapiens ubiquinol-cytochrome c reductase hinge protein, mRNA (cDNA clone MGC:1361 IMAGE:3140323), complete cds. AK311967 - Homo sapiens cDNA, FLJ92239, highly similar to Homo sapiens ubiquinol-cytochrome c reductase hinge protein (UQCRH), mRNA. Y00764 - Human mRNA for mitochondrial hinge protein. M36647 - Homo sapiens mitochondrial hinge protein precursor, mRNA, complete cds. KJ892364 - Synthetic construct Homo sapiens clone ccsbBroadEn_01758 UQCRH gene, encodes complete protein. BT007070 - Homo sapiens ubiquinol-cytochrome c reductase hinge protein mRNA, complete cds.
Biochemical and Signaling Pathways
BioCyc Knowledge Library PWY-3781 - aerobic respiration I (cytochrome c)
Reactome (by CSHL, EBI, and GO)
Protein P07919 (Reactome details) participates in the following event(s):
R-HSA-164651 Electron transfer from ubiquinol to cytochrome c of complex III R-HSA-611105 Respiratory electron transport R-HSA-163200 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. R-HSA-1428517 The citric acid (TCA) cycle and respiratory electron transport R-HSA-1430728 Metabolism