ID:QCR1_HUMAN DESCRIPTION: RecName: Full=Cytochrome b-c1 complex subunit 1, mitochondrial; AltName: Full=Complex III subunit 1; AltName: Full=Core protein I; AltName: Full=Ubiquinol-cytochrome-c reductase complex core protein 1; Flags: Precursor; FUNCTION: This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1. SUBUNIT: The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1). SUBCELLULAR LOCATION: Mitochondrion inner membrane. SIMILARITY: Belongs to the peptidase M16 family. UQCRC1/QCR1 subfamily. CAUTION: Does not seem to have a protease activity as it lack the zinc-binding site.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P31930
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0003824 catalytic activity GO:0004222 metalloendopeptidase activity GO:0008121 ubiquinol-cytochrome-c reductase activity GO:0008270 zinc ion binding GO:0031625 ubiquitin protein ligase binding GO:0044877 macromolecular complex binding GO:0046872 metal ion binding
Biological Process: GO:0006119 oxidative phosphorylation GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c GO:0009060 aerobic respiration GO:0014823 response to activity GO:0016485 protein processing GO:0043279 response to alkaloid GO:0055114 oxidation-reduction process
L16842 - Human ubiquinol cytochrome-c reductase core I protein mRNA, complete cds. D26485 - Homo sapiens mRNA for core I protein, complete cds. AK300694 - Homo sapiens cDNA FLJ51625 complete cds, highly similar to Ubiquinol-cytochrome-c reductase complex coreprotein I, mitochondrial precursor (EC 1.10.2.2). AK129903 - Homo sapiens cDNA FLJ26393 fis, clone HRT07614, highly similar to Ubiquinol-cytochrome C reductase complex core protein I, mitochondrial precursor (EC 1.10.2.2). BC009586 - Homo sapiens ubiquinol-cytochrome c reductase core protein I, mRNA (cDNA clone MGC:14649 IMAGE:4096628), complete cds. JD326650 - Sequence 307674 from Patent EP1572962. JD123218 - Sequence 104242 from Patent EP1572962. JD114592 - Sequence 95616 from Patent EP1572962. AK313090 - Homo sapiens cDNA, FLJ93573, highly similar to Homo sapiens ubiquinol-cytochrome c reductase core protein I(UQCRC1), mRNA. AB590667 - Synthetic construct DNA, clone: pFN21AE1938, Homo sapiens UQCRC1 gene for ubiquinol-cytochrome c reductase core protein I, without stop codon, in Flexi system. JD022529 - Sequence 3553 from Patent EP1572962. AK302840 - Homo sapiens cDNA FLJ52292 complete cds, highly similar to Ubiquinol-cytochrome-c reductase complex coreprotein I, mitochondrial precursor (EC 1.10.2.2).
Biochemical and Signaling Pathways
BioCyc Knowledge Library PWY-3781 - aerobic respiration I (cytochrome c)
BioCarta from NCI Cancer Genome Anatomy Project h_etcPathway - Electron Transport Reaction in Mitochondria
Reactome (by CSHL, EBI, and GO)
Protein P31930 (Reactome details) participates in the following event(s):
R-HSA-164651 Electron transfer from ubiquinol to cytochrome c of complex III R-HSA-611105 Respiratory electron transport R-HSA-163200 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. R-HSA-1428517 The citric acid (TCA) cycle and respiratory electron transport R-HSA-1430728 Metabolism
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
