ID:UGGG1_HUMAN DESCRIPTION: RecName: Full=UDP-glucose:glycoprotein glucosyltransferase 1; Short=UGT1; Short=hUGT1; EC=2.4.1.-; AltName: Full=UDP--Glc:glycoprotein glucosyltransferase; AltName: Full=UDP-glucose ceramide glucosyltransferase-like 1; Flags: Precursor; FUNCTION: Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation. COFACTOR: Calcium or manganese. PATHWAY: Protein modification; protein glycosylation. SUBUNIT: Monomer as well as in a tight complex with SEP15 (By similarity). INTERACTION: P25942:CD40; NbExp=1; IntAct=EBI-1056389, EBI-525714; Q9NRB3:CHST12; NbExp=1; IntAct=EBI-1056389, EBI-1042837; P30450:HLA-A; NbExp=1; IntAct=EBI-1056389, EBI-1042870; P30457:HLA-A; NbExp=1; IntAct=EBI-1056389, EBI-1049899; Q9UGT4:SUSD2; NbExp=1; IntAct=EBI-1056389, EBI-1054721; Q92956:TNFRSF14; NbExp=1; IntAct=EBI-1056389, EBI-1056653; O95388:WISP1; NbExp=1; IntAct=EBI-1056389, EBI-1050638; SUBCELLULAR LOCATION: Endoplasmic reticulum lumen. Endoplasmic reticulum-Golgi intermediate compartment. TISSUE SPECIFICITY: Higher levels in pancreas, skeletal muscle, kidney, and brain. Low levels in lung and heart. INDUCTION: By tunicamycin and A23187. Induced 3-4 fold 10 hours after treatment. DOMAIN: The N-terminal non-catalytic domain is assumed to mediate recognition of proteins with partial folding defects (By similarity). SIMILARITY: Belongs to the glycosyltransferase 8 family. SEQUENCE CAUTION: Sequence=AAY14885.1; Type=Erroneous gene model prediction; Sequence=BAB14632.1; Type=Erroneous initiation; WEB RESOURCE: Name=GGDB; Note=GlycoGene database; URL="http://riodb.ibase.aist.go.jp/rcmg/ggdb/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9NYU2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Protein Q9NYU2 (Reactome details) participates in the following event(s):
R-HSA-548884 UGGT1,2 transfers glucose from DbGP to (un)folded protein:(GlcNAc)2 (Man)8b R-HSA-901032 ER Quality Control Compartment (ERQC) R-HSA-901042 Calnexin/calreticulin cycle R-HSA-532668 N-glycan trimming in the ER and Calnexin/Calreticulin cycle R-HSA-446203 Asparagine N-linked glycosylation R-HSA-597592 Post-translational protein modification R-HSA-392499 Metabolism of proteins
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
