ID:UBX2B_HUMAN DESCRIPTION: RecName: Full=UBX domain-containing protein 2B; AltName: Full=NSFL1 cofactor p37; AltName: Full=p97 cofactor p37; FUNCTION: Adapter protein required for Golgi and endoplasmic reticulum biogenesis. Involved in Golgi and endoplasmic reticulum maintenance during interphase and in their reassembly at the end of mitosis. The complex formed with VCP has membrane fusion activity; membrane fusion activity requires USO1-GOLGA2 tethering and BET1L. VCPIP1 is also required, but not its deubiquitinating activity. SUBUNIT: Interacts with VCP. Does not bind ubiquitin (By similarity). SUBCELLULAR LOCATION: Nucleus (By similarity). Cytoplasm, cytosol (By similarity). Endoplasmic reticulum (By similarity). Golgi apparatus (By similarity). SIMILARITY: Belongs to the NSFL1C family. SIMILARITY: Contains 1 SEP domain. SIMILARITY: Contains 1 UBX domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q14CS0
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.