Human Gene UBL5 (ENST00000586895.6_4) from GENCODE V47lift37
  Description: ubiquitin like 5, transcript variant 2 (from RefSeq NM_001048241.3)
Gencode Transcript: ENST00000586895.6_4
Gencode Gene: ENSG00000198258.11_5
Transcript (Including UTRs)
   Position: hg19 chr19:9,938,594-9,940,791 Size: 2,198 Total Exon Count: 5 Strand: +
Coding Region
   Position: hg19 chr19:9,939,014-9,940,684 Size: 1,671 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:9,938,594-9,940,791)mRNA (may differ from genome)Protein (73 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: UBL5_HUMAN
DESCRIPTION: RecName: Full=Ubiquitin-like protein 5;
SUBUNIT: Interacts with CLK1, CLK3 and CLK4.
SUBCELLULAR LOCATION: Cytoplasm.
TISSUE SPECIFICITY: Ubiquitous. Highest level of expression in heart, skeletal muscle, kidney, liver, iris and lymphoblasts.
SIMILARITY: Contains 1 ubiquitin-like domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: UBL5
Diseases sorted by gene-association score: obesity (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 220.84 RPKM in Pituitary
Total median expression: 7018.16 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -28.5078-0.365 Picture PostScript Text
3' UTR -12.70107-0.119 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000626 - Ubiquitin

Pfam Domains:
PF00240 - Ubiquitin family
PF14560 - Ubiquitin-like domain

SCOP Domains:
54189 - Ribosomal proteins S24e, L23 and L15e
54236 - Ubiquitin-like
56502 - gp120 core

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1P0R - NMR MuPIT


ModBase Predicted Comparative 3D Structure on Q9BZL1
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologGenome BrowserGenome Browser
Gene DetailsGene Details Gene DetailsGene DetailsGene Details
Gene SorterGene Sorter Gene SorterGene SorterGene Sorter
 RGD  WormBaseSGD
    Protein SequenceProtein Sequence
    AlignmentAlignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0031386 protein tag

Biological Process:
GO:0000398 mRNA splicing, via spliceosome
GO:0006464 cellular protein modification process
GO:1903955 positive regulation of protein targeting to mitochondrion

Cellular Component:
GO:0005634 nucleus
GO:0005737 cytoplasm


-  Descriptions from all associated GenBank mRNAs
  AK311889 - Homo sapiens cDNA, FLJ92155, highly similar to Homo sapiens ubiquitin-like 5 (UBL5), mRNA.
AK128885 - Homo sapiens cDNA FLJ46917 fis, clone THYMU2018841, moderately similar to Homo sapiens ubiquitin-like 5 (UBL5).
HM005530 - Homo sapiens clone HTL-T-217 testicular tissue protein Li 217 mRNA, complete cds.
AK309258 - Homo sapiens cDNA, FLJ99299.
AF313915 - Homo sapiens ubiquitin-like 5 protein (UBL5) mRNA, complete cds.
BC007053 - Homo sapiens ubiquitin-like 5, mRNA (cDNA clone MGC:12473 IMAGE:3827384), complete cds.
BC110839 - Homo sapiens ubiquitin-like 5, mRNA (cDNA clone MGC:131795 IMAGE:6474495), complete cds.
JD149529 - Sequence 130553 from Patent EP1572962.
KJ894480 - Synthetic construct Homo sapiens clone ccsbBroadEn_03874 UBL5 gene, encodes complete protein.
AB527989 - Synthetic construct DNA, clone: pF1KB6703, Homo sapiens UBL5 gene for ubiquitin-like 5, without stop codon, in Flexi system.
BT007355 - Homo sapiens ubiquitin-like 5 mRNA, complete cds.
JD171612 - Sequence 152636 from Patent EP1572962.
JD261364 - Sequence 242388 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_mPRPathway - How Progesterone Initiates the Oocyte Maturation

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000586895.1, ENST00000586895.2, ENST00000586895.3, ENST00000586895.4, ENST00000586895.5, NM_001048241, Q2NL89, Q9BZL1, UBL5_HUMAN, uc326qqa.1, uc326qqa.2
UCSC ID: ENST00000586895.6_4
RefSeq Accession: NM_001048241.3
Protein: Q9BZL1 (aka UBL5_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.