ID:UBE3C_HUMAN DESCRIPTION: RecName: Full=Ubiquitin-protein ligase E3C; EC=6.3.2.-; AltName: Full=HectH2; FUNCTION: E3 ubiquitin-protein ligase that accepts ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2D1 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Can assemble unanchored poly-ubiquitin chains in either 'Lys-29'- or 'Lys-48'-linked polyubiquitin chains. Has preference for 'Lys-48' linkages. It can target itself for ubiquitination in vitro and may promote its own degradation in vivo. PATHWAY: Protein modification; protein ubiquitination. SUBUNIT: Interacts with 26S proteasomes. Interacts (via the N- terminal) with CAND2; the interaction stimulates ubiquitination of CAND2 in vitro. May interact (via the HECT domain) with UBE2D1 and, less efficiently, with UBE2L3. SUBCELLULAR LOCATION: Nucleus (Potential). TISSUE SPECIFICITY: Highly expressed in skeletal muscle. Detected at much lower levels in kidney and pancreas. DOMAIN: The C-terminal is necessary and sufficient for the poly- ubiquitin chain assembly. MISCELLANEOUS: A cysteine residue is required for ubiquitin- thioester formation. SIMILARITY: Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain. SIMILARITY: Contains 1 IQ domain. SEQUENCE CAUTION: Sequence=BAA02799.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q15386
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
D13635 - Homo sapiens KIAA0010 mRNA. AB385265 - Synthetic construct DNA, clone: pF1KA0010, Homo sapiens UBE3C gene for ubiquitin-protein ligase E3C, complete cds, without stop codon, in Flexi system. AK295138 - Homo sapiens cDNA FLJ61262 complete cds, highly similar to Ubiquitin-protein ligase E3C (EC 6.3.2.-). AK127280 - Homo sapiens cDNA FLJ45347 fis, clone BRHIP3011082, highly similar to Homo sapiens ubiquitin-protein isopeptide ligase (E3). BC026241 - Homo sapiens ubiquitin protein ligase E3C, mRNA (cDNA clone IMAGE:4696496), complete cds. BC014029 - Homo sapiens ubiquitin protein ligase E3C, mRNA (cDNA clone MGC:19944 IMAGE:4541634), complete cds. JD129671 - Sequence 110695 from Patent EP1572962. CU693170 - Synthetic construct Homo sapiens gateway clone IMAGE:100022263 5' read UBE3C mRNA. CU680748 - Synthetic construct Homo sapiens gateway clone IMAGE:100019980 5' read UBE3C mRNA. KJ906004 - Synthetic construct Homo sapiens clone ccsbBroadEn_15674 UBE3C gene, encodes complete protein. KJ902011 - Synthetic construct Homo sapiens clone ccsbBroadEn_11405 UBE3C gene, encodes complete protein. JD418526 - Sequence 399550 from Patent EP1572962. JD130111 - Sequence 111135 from Patent EP1572962. JD324844 - Sequence 305868 from Patent EP1572962. JD199233 - Sequence 180257 from Patent EP1572962. JD423029 - Sequence 404053 from Patent EP1572962. JD304170 - Sequence 285194 from Patent EP1572962. JD282476 - Sequence 263500 from Patent EP1572962. JD148177 - Sequence 129201 from Patent EP1572962. JD249466 - Sequence 230490 from Patent EP1572962. JD547368 - Sequence 528392 from Patent EP1572962. JD131215 - Sequence 112239 from Patent EP1572962. JD540363 - Sequence 521387 from Patent EP1572962. JD456762 - Sequence 437786 from Patent EP1572962. JD296181 - Sequence 277205 from Patent EP1572962. JD226759 - Sequence 207783 from Patent EP1572962. JD546229 - Sequence 527253 from Patent EP1572962. JD181229 - Sequence 162253 from Patent EP1572962. JD173163 - Sequence 154187 from Patent EP1572962. JD038621 - Sequence 19645 from Patent EP1572962. JD077184 - Sequence 58208 from Patent EP1572962. JD360311 - Sequence 341335 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q15386 (Reactome details) participates in the following event(s):
R-HSA-983157 Interaction of E3 with substrate and E2-Ub complex R-HSA-983147 Release of E3 from polyubiquitinated substrate R-HSA-983140 Transfer of Ub from E2 to substrate and release of E2 R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983169 Class I MHC mediated antigen processing & presentation R-HSA-1280218 Adaptive Immune System R-HSA-168256 Immune System
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
