ID:UB2V1_HUMAN DESCRIPTION: RecName: Full=Ubiquitin-conjugating enzyme E2 variant 1; Short=UEV-1; AltName: Full=CROC-1; AltName: Full=TRAF6-regulated IKK activator 1 beta Uev1A; FUNCTION: Has no ubiquitin ligase activity on its own. The UBE2V1- UBE2N heterodimer catalyzes the synthesis of non-canonical poly- ubiquitin chains that are linked through Lys-63. This type of poly-ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF-kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. SUBUNIT: Heterodimer with UBE2N. Interacts (UBE2V2-UBE2N heterodimer) with the E3 ligase STUB1 (via the U-box domain); the complex has a specific 'Lys-63'-linked polyubiquitination activity. Interacts with TRAF6. INTERACTION: P61088:UBE2N; NbExp=9; IntAct=EBI-1050671, EBI-1052908; P98170:XIAP; NbExp=2; IntAct=EBI-1050671, EBI-517127; Q8ND25:ZNRF1; NbExp=2; IntAct=EBI-1050671, EBI-2129250; SUBCELLULAR LOCATION: Nucleus. Note=Excluded from the nucleolus. TISSUE SPECIFICITY: Highly expressed in thyroid, pancreas, spinal cord, lymph node, trachea, adrenal gland, bone marrow and pancreas. Detected at low levels in heart, breast, placenta, brain, liver, kidney, stomach and lung. INDUCTION: Down-regulated during differentiation of cultured colon adenocarcinoma cells. MISCELLANEOUS: In human, TMEM189/KUA and UBE2V1/UEV1 are adjacent genes which can produce independent proteins and can also be fused to form a TMEM189-UBE2V1 hybrid protein. SIMILARITY: Belongs to the ubiquitin-conjugating enzyme family. SEQUENCE CAUTION: Sequence=AAH08944.2; Type=Erroneous initiation; Sequence=CAC16955.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q13404
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BC172339 - Synthetic construct Homo sapiens clone IMAGE:100069033, MGC:199044 TMEM189-UBE2V1 readthrough transcript (TMEM189-UBE2V1) mRNA, encodes complete protein. AB587452 - Synthetic construct DNA, clone: pF1KB7917, Homo sapiens TMEM189-UBE2V1 gene for TMEM189-UBE2V1 readthrough, without stop codon, in Flexi system. U49278 - Homo sapiens UEV-1 (UBE2V) mRNA, partial cds. BX647511 - Homo sapiens mRNA; cDNA DKFZp686I21199 (from clone DKFZp686I21199). BX648147 - Homo sapiens mRNA; cDNA DKFZp686G1080 (from clone DKFZp686G1080). U97279 - Homo sapiens UEV-1 (UBE2V) alternatively spliced incompletely processed mRNA, partial cds. AL110132 - Homo sapiens mRNA; cDNA DKFZp564H192 (from clone DKFZp564H192). JD557645 - Sequence 538669 from Patent EP1572962. AF049671 - Homo sapiens clone CIR1 cell immortalization-related mRNA sequence. U39360 - Homo sapiens DNA-binding protein (CROC-1A) mRNA, complete cds. U39361 - Homo sapiens DNA-binding protein (CROC-1B) mRNA, complete cds. BC008944 - Homo sapiens ubiquitin-conjugating enzyme E2 variant 1, mRNA (cDNA clone IMAGE:2960953), partial cds. BC000468 - Homo sapiens ubiquitin-conjugating enzyme E2 variant 1, mRNA (cDNA clone MGC:8586 IMAGE:2961017), complete cds. JD273306 - Sequence 254330 from Patent EP1572962. JD101605 - Sequence 82629 from Patent EP1572962. JD315254 - Sequence 296278 from Patent EP1572962. JD558001 - Sequence 539025 from Patent EP1572962. JD272684 - Sequence 253708 from Patent EP1572962. JD299451 - Sequence 280475 from Patent EP1572962. DQ598317 - Homo sapiens piRNA piR-36383, complete sequence. JD269185 - Sequence 250209 from Patent EP1572962. JD133135 - Sequence 114159 from Patent EP1572962. JD104747 - Sequence 85771 from Patent EP1572962. JD192643 - Sequence 173667 from Patent EP1572962. JD247296 - Sequence 228320 from Patent EP1572962. JD413564 - Sequence 394588 from Patent EP1572962. JD324264 - Sequence 305288 from Patent EP1572962. JD240731 - Sequence 221755 from Patent EP1572962. JD083928 - Sequence 64952 from Patent EP1572962. JD110278 - Sequence 91302 from Patent EP1572962. JD202857 - Sequence 183881 from Patent EP1572962. JD377384 - Sequence 358408 from Patent EP1572962. JD320567 - Sequence 301591 from Patent EP1572962. JD391827 - Sequence 372851 from Patent EP1572962. JD433549 - Sequence 414573 from Patent EP1572962. JD272706 - Sequence 253730 from Patent EP1572962. JD403675 - Sequence 384699 from Patent EP1572962. JD253152 - Sequence 234176 from Patent EP1572962. JD297643 - Sequence 278667 from Patent EP1572962. JD218720 - Sequence 199744 from Patent EP1572962. JD054937 - Sequence 35961 from Patent EP1572962. JD498860 - Sequence 479884 from Patent EP1572962. JD498861 - Sequence 479885 from Patent EP1572962. JD241200 - Sequence 222224 from Patent EP1572962. JD460143 - Sequence 441167 from Patent EP1572962. JD261094 - Sequence 242118 from Patent EP1572962. JD261096 - Sequence 242120 from Patent EP1572962. JD228794 - Sequence 209818 from Patent EP1572962. JD488233 - Sequence 469257 from Patent EP1572962. JD268228 - Sequence 249252 from Patent EP1572962. JD061124 - Sequence 42148 from Patent EP1572962. BC005215 - Homo sapiens cDNA clone IMAGE:3996506. U97280 - Homo sapiens UEV1Bs (UBE2V) mRNA, alternatively spliced, partial cds. AY008273 - Homo sapiens TRAF6-regulated IKK activator 1 beta Uev1A mRNA, complete cds. U97281 - Homo sapiens UEV1As (UBE2V) mRNA, alternatively spliced, complete cds. AK314754 - Homo sapiens cDNA, FLJ95620. BT007382 - Homo sapiens ubiquitin-conjugating enzyme E2 variant 1 mRNA, complete cds. CU674232 - Synthetic construct Homo sapiens gateway clone IMAGE:100017928 5' read UBE2V1 mRNA. HQ448675 - Synthetic construct Homo sapiens clone IMAGE:100072117; CCSB004673_01 ubiquitin-conjugating enzyme E2 variant 1 (UBE2V1) gene, encodes complete protein. KJ892347 - Synthetic construct Homo sapiens clone ccsbBroadEn_01741 UBE2V1 gene, encodes complete protein.
Biochemical and Signaling Pathways
BioCyc Knowledge Library PWY-7511 - protein ubiquitination
Reactome (by CSHL, EBI, and GO)
Protein Q13404 (Reactome details) participates in the following event(s):
R-HSA-202453 Auto-ubiquitination of TRAF6 R-HSA-937050 Pellino ubiquitinates hp-IRAK1 R-HSA-975118 TRAF6 ubiquitinqtes IRF7 in a K63-dependent manner following TLR7/8 or 9 stimulation R-HSA-975122 Pellino ubiquitinates hp-IRAK1 upon TLR7/8 or 9 activation
R-HSA-8948015 hp-IRAK1:3xTRAF6 binds UBE2N:UBE2V1:K63-polyUb R-HSA-983152 Transfer of ubiquitin from E1 to E2 R-HSA-983140 Transfer of Ub from E2 to substrate and release of E2 R-HSA-446877 TRAF6 is K63 poly-ubiquitinated R-HSA-451418 Pellino ubiquitinates IRAK1 R-HSA-983157 Interaction of E3 with substrate and E2-Ub complex R-HSA-741386 RIP2 induces K63-linked ubiquitination of NEMO R-HSA-688137 RIP2 is K63 polyubiquitinated R-HSA-168915 K63-linked ubiquitination of RIP1 bound to the activated TLR complex R-HSA-9014342 K63-linked ubiquitination of RIP1 bound to the activated TLR complex R-HSA-168184 Activated TAK1 mediates phosphorylation of the IKK Complex R-HSA-450337 Activated TAK1 phosphorylates MKK4/MKK7 R-HSA-450346 activated human TAK1 phosphorylates MKK3/MKK6 R-HSA-202424 Downstream TCR signaling R-HSA-2871837 FCERI mediated NF-kB activation R-HSA-5607764 CLEC7A (Dectin-1) signaling R-HSA-937039 IRAK1 recruits IKK complex R-HSA-975110 TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975144 IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-9020702 Interleukin-1 signaling R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation R-HSA-202403 TCR signaling R-HSA-2454202 Fc epsilon receptor (FCERI) signaling R-HSA-5621481 C-type lectin receptors (CLRs) R-HSA-166058 MyD88:Mal cascade initiated on plasma membrane R-HSA-975871 MyD88 cascade initiated on plasma membrane R-HSA-975155 MyD88 dependent cascade initiated on endosome R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-446652 Interleukin-1 family signaling R-HSA-983169 Class I MHC mediated antigen processing & presentation R-HSA-168638 NOD1/2 Signaling Pathway R-HSA-1280218 Adaptive Immune System R-HSA-168249 Innate Immune System R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade R-HSA-168142 Toll Like Receptor 10 (TLR10) Cascade R-HSA-168176 Toll Like Receptor 5 (TLR5) Cascade R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-449147 Signaling by Interleukins R-HSA-937041 IKK complex recruitment mediated by RIP1 R-HSA-168927 TICAM1, RIP1-mediated IKK complex recruitment R-HSA-168643 Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways R-HSA-168256 Immune System R-HSA-168898 Toll-Like Receptors Cascades R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade R-HSA-1280215 Cytokine Signaling in Immune system R-HSA-445989 TAK1 activates NFkB by phosphorylation and activation of IKKs complex R-HSA-450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-450302 activated TAK1 mediates p38 MAPK activation R-HSA-937061 TRIF(TICAM1)-mediated TLR4 signaling R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade R-HSA-450294 MAP kinase activation R-HSA-166166 MyD88-independent TLR4 cascade R-HSA-448424 Interleukin-17 signaling
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
