Human Gene TXNDC12 (ENST00000371626.9_6) from GENCODE V47lift37
  Description: thioredoxin domain containing 12, transcript variant 1 (from RefSeq NM_015913.4)
Gencode Transcript: ENST00000371626.9_6
Gencode Gene: ENSG00000117862.14_10
Transcript (Including UTRs)
   Position: hg19 chr1:52,485,803-52,520,863 Size: 35,061 Total Exon Count: 7 Strand: -
Coding Region
   Position: hg19 chr1:52,486,605-52,520,768 Size: 34,164 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:52,485,803-52,520,863)mRNA (may differ from genome)Protein (172 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedUniProtKBWikipedia
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: TXD12_HUMAN
DESCRIPTION: RecName: Full=Thioredoxin domain-containing protein 12; EC=1.8.4.2; AltName: Full=Endoplasmic reticulum resident protein 18; Short=ER protein 18; Short=ERp18; AltName: Full=Endoplasmic reticulum resident protein 19; Short=ER protein 19; Short=ERp19; AltName: Full=Thioredoxin-like protein p19; AltName: Full=hTLP19; Flags: Precursor;
FUNCTION: Possesses significant protein thiol-disulfide oxidase activity.
CATALYTIC ACTIVITY: 2 glutathione + protein-disulfide = glutathione disulfide + protein-dithiol.
BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=25 uM for Asn-Arg-Cys-Ser-Gln-Gly-Ser-Cys-Trp-Asn; pH dependence: Optimum pH is 6.5;
SUBCELLULAR LOCATION: Endoplasmic reticulum lumen.
TISSUE SPECIFICITY: Widely expressed.
SIMILARITY: Contains 1 thioredoxin domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 31.19 RPKM in Cells - Cultured fibroblasts
Total median expression: 973.29 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -40.4095-0.425 Picture PostScript Text
3' UTR -189.30802-0.236 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR012336 - Thioredoxin-like_fold
IPR017937 - Thioredoxin_CS

Pfam Domains:
PF00085 - Thioredoxin
PF13899 - Thioredoxin-like

SCOP Domains:
52833 - Thioredoxin-like

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1SEN - X-ray MuPIT 2K8V - NMR MuPIT


ModBase Predicted Comparative 3D Structure on O95881
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0015037 peptide disulfide oxidoreductase activity
GO:0016491 oxidoreductase activity
GO:0019153 protein-disulfide reductase (glutathione) activity

Biological Process:
GO:0030154 cell differentiation
GO:0045454 cell redox homeostasis
GO:0055114 oxidation-reduction process
GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

Cellular Component:
GO:0005783 endoplasmic reticulum
GO:0005788 endoplasmic reticulum lumen


-  Descriptions from all associated GenBank mRNAs
  LF206548 - JP 2014500723-A/14051: Polycomb-Associated Non-Coding RNAs.
BC008953 - Homo sapiens thioredoxin domain containing 12 (endoplasmic reticulum), mRNA (cDNA clone MGC:3735 IMAGE:2959502), complete cds.
BC001493 - Homo sapiens thioredoxin domain containing 12 (endoplasmic reticulum), mRNA (cDNA clone MGC:1825 IMAGE:3506109), complete cds.
AF131758 - Homo sapiens clone 24952 mRNA sequence, complete cds.
AF543416 - Homo sapiens thioredoxin-like protein p19 (TLP19) mRNA, complete cds.
AK075409 - Homo sapiens cDNA PSEC0100 fis, clone NT2RP2002927, highly similar to Thioredoxin domain-containing protein 12 precursor (EC 1.8.4.2).
AK056169 - Homo sapiens cDNA FLJ31607 fis, clone NT2RI2002819, weakly similar to PUTATIVE SECRETED PROTEIN XAG PRECURSOR.
BC008913 - Homo sapiens thioredoxin domain containing 12 (endoplasmic reticulum), mRNA (cDNA clone MGC:15395 IMAGE:3659407), complete cds.
JD540093 - Sequence 521117 from Patent EP1572962.
LF356117 - JP 2014500723-A/163620: Polycomb-Associated Non-Coding RNAs.
LF356116 - JP 2014500723-A/163619: Polycomb-Associated Non-Coding RNAs.
AY358982 - Homo sapiens clone DNA67300 ETRP713 (UNQ713) mRNA, complete cds.
JD503174 - Sequence 484198 from Patent EP1572962.
JD524550 - Sequence 505574 from Patent EP1572962.
JD316285 - Sequence 297309 from Patent EP1572962.
JD130242 - Sequence 111266 from Patent EP1572962.
JD073388 - Sequence 54412 from Patent EP1572962.
JD469454 - Sequence 450478 from Patent EP1572962.
LF356115 - JP 2014500723-A/163618: Polycomb-Associated Non-Coding RNAs.
JD248368 - Sequence 229392 from Patent EP1572962.
HQ448666 - Synthetic construct Homo sapiens clone IMAGE:100072107; CCSB003545_01 thioredoxin domain containing 12 (endoplasmic reticulum) (TXNDC12) gene, encodes complete protein.
KJ893793 - Synthetic construct Homo sapiens clone ccsbBroadEn_03187 TXNDC12 gene, encodes complete protein.
KJ898811 - Synthetic construct Homo sapiens clone ccsbBroadEn_08205 TXNDC12 gene, encodes complete protein.
CU674738 - Synthetic construct Homo sapiens gateway clone IMAGE:100017963 5' read TXNDC12 mRNA.
AK094262 - Homo sapiens cDNA FLJ36943 fis, clone BRACE2005562.
LF356112 - JP 2014500723-A/163615: Polycomb-Associated Non-Coding RNAs.
LF356107 - JP 2014500723-A/163610: Polycomb-Associated Non-Coding RNAs.
LF356104 - JP 2014500723-A/163607: Polycomb-Associated Non-Coding RNAs.
JD424199 - Sequence 405223 from Patent EP1572962.
MA442125 - JP 2018138019-A/14051: Polycomb-Associated Non-Coding RNAs.
MA591694 - JP 2018138019-A/163620: Polycomb-Associated Non-Coding RNAs.
MA591693 - JP 2018138019-A/163619: Polycomb-Associated Non-Coding RNAs.
MA591692 - JP 2018138019-A/163618: Polycomb-Associated Non-Coding RNAs.
MA591689 - JP 2018138019-A/163615: Polycomb-Associated Non-Coding RNAs.
MA591684 - JP 2018138019-A/163610: Polycomb-Associated Non-Coding RNAs.
MA591681 - JP 2018138019-A/163607: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  BioCyc Knowledge Library
GLUT-REDOX-PWY - glutathione-glutaredoxin redox reactions

-  Other Names for This Gene
  Alternate Gene Symbols: B3KQS0, ENST00000371626.1, ENST00000371626.2, ENST00000371626.3, ENST00000371626.4, ENST00000371626.5, ENST00000371626.6, ENST00000371626.7, ENST00000371626.8, NM_015913, O95881, Q5T1T4, Q96H50, TLP19 , TXD12_HUMAN, TXNDC12 , uc318jgz.1, uc318jgz.2, UNQ713/PRO1376
UCSC ID: ENST00000371626.9_6
RefSeq Accession: NM_015913.4
Protein: O95881 (aka TXD12_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.