Human Gene TXLNA (ENST00000373610.8_4) from GENCODE V47lift37
  Description: taxilin alpha, transcript variant 1 (from RefSeq NM_175852.4)
Gencode Transcript: ENST00000373610.8_4
Gencode Gene: ENSG00000084652.16_7
Transcript (Including UTRs)
   Position: hg19 chr1:32,645,276-32,663,886 Size: 18,611 Total Exon Count: 11 Strand: +
Coding Region
   Position: hg19 chr1:32,645,947-32,660,796 Size: 14,850 Coding Exon Count: 10 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:32,645,276-32,663,886)mRNA (may differ from genome)Protein (546 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: TXLNA_HUMAN
DESCRIPTION: RecName: Full=Alpha-taxilin;
FUNCTION: May be involved in intracellular vesicle traffic and potentially in calcium-dependent exocytosis in neuroendocrine cells.
SUBUNIT: Binds to the C-terminal coiled coil region of syntaxin family members STX1A, STX3A and STX4A, but not when these proteins are complexed with SNAP25, VAMP2 or STXBP1, suggesting that it interacts with syntaxins that do not form the SNARE complex.
INTERACTION: Q9QYP6:Azi2 (xeno); NbExp=2; IntAct=EBI-359793, EBI-6115874; Q9BZA4:CYorf15B; NbExp=2; IntAct=EBI-359793, EBI-6115828; Q13765:NACA; NbExp=2; IntAct=EBI-359793, EBI-712216; Q9UHD2:TBK1; NbExp=4; IntAct=EBI-359793, EBI-356402; Q8N3L3:TXLNB; NbExp=2; IntAct=EBI-359793, EBI-6116822;
TISSUE SPECIFICITY: Ubiquitous, with much higher expression in heart, kidney, liver and pancreas.
SIMILARITY: Belongs to the taxilin family.
CAUTION: Was originally (PubMed:8327514) thought to be a high molecular weight interleukin (IL-14 or IL14).
SEQUENCE CAUTION: Sequence=AAH46565.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: TXLNA
Diseases sorted by gene-association score: inclusion conjunctivitis (2), amyotrophic lateral sclerosis type 10 (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 32.68 RPKM in Testis
Total median expression: 978.40 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -48.00134-0.358 Picture PostScript Text
3' UTR -1149.503090-0.372 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR026183 - Taxilin_fam

Pfam Domains:
PF09728 - Myosin-like coiled-coil protein

SCOP Domains:
57997 - Tropomyosin

ModBase Predicted Comparative 3D Structure on P40222
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005125 cytokine activity
GO:0005515 protein binding
GO:0019905 syntaxin binding
GO:0030372 high molecular weight B cell growth factor receptor binding

Biological Process:
GO:0006887 exocytosis
GO:0008283 cell proliferation
GO:0010469 regulation of receptor activity
GO:0019221 cytokine-mediated signaling pathway
GO:0042113 B cell activation

Cellular Component:
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane


-  Descriptions from all associated GenBank mRNAs
  AL832636 - Homo sapiens mRNA; cDNA DKFZp451I0918 (from clone DKFZp451I0918); complete cds.
AL832338 - Homo sapiens mRNA; cDNA DKFZp451K215 (from clone DKFZp451K215).
AK096939 - Homo sapiens cDNA FLJ39620 fis, clone SMINT2001114.
AL832637 - Homo sapiens mRNA; cDNA DKFZp451J0118 (from clone DKFZp451J0118).
AF516206 - Homo sapiens taxilin mRNA, complete cds.
BC080578 - Homo sapiens taxilin alpha, mRNA (cDNA clone MGC:99831 IMAGE:6598234), complete cds.
BC103823 - Homo sapiens taxilin alpha, mRNA (cDNA clone MGC:118870 IMAGE:40001224), complete cds.
BC103824 - Homo sapiens taxilin alpha, mRNA (cDNA clone MGC:118871 IMAGE:40001225), complete cds.
BC103825 - Homo sapiens taxilin alpha, mRNA (cDNA clone IMAGE:40001227), partial cds.
AM393586 - Synthetic construct Homo sapiens clone IMAGE:100002149 for hypothetical protein (TXLNA gene).
KJ895789 - Synthetic construct Homo sapiens clone ccsbBroadEn_05183 TXLNA gene, encodes complete protein.
KJ900408 - Synthetic construct Homo sapiens clone ccsbBroadEn_09802 TXLNA gene, encodes complete protein.
AB463303 - Synthetic construct DNA, clone: pF1KB8697, Homo sapiens TXLNA gene for taxilin alpha, without stop codon, in Flexi system.
BC046565 - Homo sapiens taxilin alpha, mRNA (cDNA clone IMAGE:5534975), complete cds.
BC029686 - Homo sapiens taxilin alpha, mRNA (cDNA clone IMAGE:4993857), partial cds.
JD233698 - Sequence 214722 from Patent EP1572962.
JD234764 - Sequence 215788 from Patent EP1572962.
JD045374 - Sequence 26398 from Patent EP1572962.
AK096161 - Homo sapiens cDNA FLJ38842 fis, clone MESAN2003622.
JD534020 - Sequence 515044 from Patent EP1572962.
JD450308 - Sequence 431332 from Patent EP1572962.
BC065263 - Homo sapiens cDNA clone IMAGE:6157023, partial cds.
AL713662 - Homo sapiens mRNA; cDNA DKFZp667F1912 (from clone DKFZp667F1912).
JD545718 - Sequence 526742 from Patent EP1572962.
JD074677 - Sequence 55701 from Patent EP1572962.
JD474342 - Sequence 455366 from Patent EP1572962.
JD189287 - Sequence 170311 from Patent EP1572962.
JD219580 - Sequence 200604 from Patent EP1572962.
JD452036 - Sequence 433060 from Patent EP1572962.
JD398109 - Sequence 379133 from Patent EP1572962.
JD403410 - Sequence 384434 from Patent EP1572962.
JD374024 - Sequence 355048 from Patent EP1572962.
AF070546 - Homo sapiens clone 24607 mRNA sequence.
JD151437 - Sequence 132461 from Patent EP1572962.
JD054417 - Sequence 35441 from Patent EP1572962.
JD066271 - Sequence 47295 from Patent EP1572962.
JD167834 - Sequence 148858 from Patent EP1572962.
JD394718 - Sequence 375742 from Patent EP1572962.
JD477377 - Sequence 458401 from Patent EP1572962.
JD200221 - Sequence 181245 from Patent EP1572962.
JD157265 - Sequence 138289 from Patent EP1572962.
JD074543 - Sequence 55567 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_cytokinePathway - Cytokine Network

Reactome (by CSHL, EBI, and GO)

Protein P40222 (Reactome details) participates in the following event(s):

R-HSA-449117 TXLNA (IL14) binds syntaxin1A
R-HSA-9014052 TXLNA (IL14) binds syntaxin3
R-HSA-9014074 TXLNA (IL14) binds syntaxin4
R-HSA-449836 Other interleukin signaling
R-HSA-449147 Signaling by Interleukins
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-168256 Immune System

-  Other Names for This Gene
  Alternate Gene Symbols: D3DPP6, ENST00000373610.1, ENST00000373610.2, ENST00000373610.3, ENST00000373610.4, ENST00000373610.5, ENST00000373610.6, ENST00000373610.7, NM_175852, P40222, Q5TFJ6, Q66K62, Q86T54, Q86T85, Q86T86, Q86Y86, Q86YW3, Q8N2Y3, TXLN, TXLNA_HUMAN, uc318kxn.1, uc318kxn.2
UCSC ID: ENST00000373610.8_4
RefSeq Accession: NM_175852.4
Protein: P40222 (aka TXLNA_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.