Human Gene TULP2 (ENST00000221399.8_7) from GENCODE V47lift37
  Description: TUB like protein 2 (from RefSeq NM_003323.3)
Gencode Transcript: ENST00000221399.8_7
Gencode Gene: ENSG00000104804.9_17
Transcript (Including UTRs)
   Position: hg19 chr19:49,384,224-49,402,001 Size: 17,778 Total Exon Count: 13 Strand: -
Coding Region
   Position: hg19 chr19:49,384,268-49,401,125 Size: 16,858 Coding Exon Count: 12 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr19:49,384,224-49,402,001)mRNA (may differ from genome)Protein (520 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MGIOMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: TULP2_HUMAN
DESCRIPTION: RecName: Full=Tubby-related protein 2; AltName: Full=Cancer/testis antigen 65; Short=CT65; AltName: Full=Tubby-like protein 2;
SUBCELLULAR LOCATION: Cytoplasm (By similarity). Secreted (By similarity). Note=Does not have a cleavable signal peptide and is secreted by a non-conventional pathway (By similarity).
TISSUE SPECIFICITY: Strongly expressed in testis. Also expressed in retina. Expressed in cancer cell lines.
SIMILARITY: Belongs to the TUB family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 29.92 RPKM in Testis
Total median expression: 36.94 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -58.10156-0.372 Picture PostScript Text
3' UTR -5.1044-0.116 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000007 - Tubby_C
IPR025659 - Tubby_C-like
IPR018066 - Tubby_C_CS
IPR005398 - Tubby_N

Pfam Domains:
PF01167 - Tub family
PF16322 - Tubby N-terminal

SCOP Domains:
54518 - Tubby C-terminal domain-like

ModBase Predicted Comparative 3D Structure on O00295
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0035091 phosphatidylinositol binding
GO:0044877 macromolecular complex binding

Biological Process:
GO:0007601 visual perception
GO:0097500 receptor localization to non-motile cilium
GO:1903546 protein localization to photoreceptor outer segment

Cellular Component:
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005929 cilium


-  Descriptions from all associated GenBank mRNAs
  U82469 - Human tubby related protein 2 (TULP2) mRNA, complete cds.
LF384267 - JP 2014500723-A/191770: Polycomb-Associated Non-Coding RNAs.
BC026070 - Homo sapiens tubby like protein 2, mRNA (cDNA clone MGC:26357 IMAGE:4837710), complete cds.
JD273735 - Sequence 254759 from Patent EP1572962.
DQ890936 - Synthetic construct clone IMAGE:100003566; FLH167684.01X; RZPDo839D1190D tubby like protein 2 (TULP2) gene, encodes complete protein.
KJ892334 - Synthetic construct Homo sapiens clone ccsbBroadEn_01728 TULP2 gene, encodes complete protein.
LF367874 - JP 2014500723-A/175377: Polycomb-Associated Non-Coding RNAs.
LF367872 - JP 2014500723-A/175375: Polycomb-Associated Non-Coding RNAs.
MA619844 - JP 2018138019-A/191770: Polycomb-Associated Non-Coding RNAs.
MA603451 - JP 2018138019-A/175377: Polycomb-Associated Non-Coding RNAs.
MA603449 - JP 2018138019-A/175375: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000221399.1, ENST00000221399.2, ENST00000221399.3, ENST00000221399.4, ENST00000221399.5, ENST00000221399.6, ENST00000221399.7, NM_003323, O00295, Q8TC50, TUBL2, TULP2_HUMAN, uc317daw.1, uc317daw.2
UCSC ID: ENST00000221399.8_7
RefSeq Accession: NM_003323.3
Protein: O00295 (aka TULP2_HUMAN or TUL2_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.