Human Gene TUBE1 (ENST00000368662.10_7) from GENCODE V47lift37

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Description: tubulin epsilon 1 (from RefSeq NM_016262.5)
Gencode Transcript: ENST00000368662.10_7
Gencode Gene: ENSG00000074935.14_9
Transcript (Including UTRs)
Position: hg19 chr6:112,391,866-112,408,685 Size: 16,820 Total Exon Count: 12 Strand: -
Coding Region
Position: hg19 chr6:112,392,615-112,408,637 Size: 16,023 Coding Exon Count: 12

Page Index	Sequence and Links	UniProtKB Comments	Primers	MalaCards	CTD
Gene Alleles	RNA-Seq Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr6:112,391,866-112,408,685)			mRNA (may differ from genome)		Protein (475 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Malacards	MGI	OMIM	PubMed	UniProtKB
Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: TBE_HUMAN DESCRIPTION: RecName: Full=Tubulin epsilon chain; AltName: Full=Epsilon-tubulin; SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, centrosome. Note=Associated with pericentriolar material. SIMILARITY: Belongs to the tubulin family.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: TUBE1 Diseases sorted by gene-association score: chronic frontal sinusitis (5), frontal sinusitis (3), laryngeal tuberculosis (2)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene C028474 1,4-bis(2-(3,5-dichloropyridyloxy))benzene C016403 2,4-dinitrotoluene D016604 Aflatoxin B1 D000667 Ampicillin D001564 Benzo(a)pyrene D019327 Copper Sulfate D016572 Cyclosporine D003993 Dibutyl Phthalate D004958 Estradiol D006861 Hydrogen Peroxide D007213 Indomethacin D015125 Oxyquinoline D010634 Phenobarbital D012402 Rotenone D013749 Tetrachlorodibenzodioxin D013893 Thiram C006780 bisphenol A C056507 gemcitabine C016517 indole-3-carbinol C006253 pirinixic acid C517826 tetrabrominated diphenyl ether 47

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 23.70 RPKM in Brain - Cerebellum Total median expression: 421.50 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-20.30	48	-0.423	Picture	PostScript	Text
3' UTR	-131.70	749	-0.176	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR004057 - Epsilon_tubulin
IPR008280 - Tub_FtsZ_C
IPR000217 - Tubulin
IPR018316 - Tubulin/FtsZ_2-layer-sand-dom
IPR023123 - Tubulin_C
IPR017975 - Tubulin_CS
IPR003008 - Tubulin_FtsZ_GTPase

Pfam Domains:
PF00091 - Tubulin/FtsZ family, GTPase domain
PF03953 - Tubulin C-terminal domain

SCOP Domains:
52490 - Tubulin nucleotide-binding domain-like
55307 - Tubulin C-terminal domain-like

ModBase Predicted Comparative 3D Structure on Q9UJT0


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD	Ensembl

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0000166 nucleotide binding GO:0003924 GTPase activity GO:0005200 structural constituent of cytoskeleton GO:0005525 GTP binding Biological Process: GO:0007017 microtubule-based process GO:0007098 centrosome cycle Cellular Component: GO:0000242 pericentriolar material GO:0005737 cytoplasm GO:0005815 microtubule organizing center GO:0005856 cytoskeleton GO:0005874 microtubule

Descriptions from all associated GenBank mRNAs


	BC025405 - Homo sapiens tubulin, epsilon 1, mRNA (cDNA clone MGC:33406 IMAGE:4824105), complete cds. BC031101 - Homo sapiens tubulin, epsilon 1, mRNA (cDNA clone MGC:33949 IMAGE:5298159), complete cds. AK026242 - Homo sapiens cDNA: FLJ22589 fis, clone HSI03086, highly similar to AF201334 Homo sapiens epsilon-tubulin mRNA. JD323357 - Sequence 304381 from Patent EP1572962. JD224543 - Sequence 205567 from Patent EP1572962. JD114523 - Sequence 95547 from Patent EP1572962. JD245546 - Sequence 226570 from Patent EP1572962. AF201334 - Homo sapiens epsilon-tubulin mRNA, complete cds. KJ893842 - Synthetic construct Homo sapiens clone ccsbBroadEn_03236 TUBE1 gene, encodes complete protein. KJ906154 - Synthetic construct Homo sapiens clone ccsbBroadEn_15824 TUBE1 gene, encodes complete protein. DQ891503 - Synthetic construct clone IMAGE:100004133; FLH177544.01X; RZPDo839B05126D tubulin, epsilon 1 (TUBE1) gene, encodes complete protein. DQ894695 - Synthetic construct Homo sapiens clone IMAGE:100009155; FLH177540.01L; RZPDo839B05125D tubulin, epsilon 1 (TUBE1) gene, encodes complete protein. AK126191 - Homo sapiens cDNA FLJ44203 fis, clone THYMU3001083, moderately similar to Tubulin epsilon chain. CU689114 - Synthetic construct Homo sapiens gateway clone IMAGE:100019572 5' read TUBE1 mRNA. CU692994 - Synthetic construct Homo sapiens gateway clone IMAGE:100019571 5' read TUBE1 mRNA.

Other Names for This Gene


	Alternate Gene Symbols: ENST00000368662.1, ENST00000368662.2, ENST00000368662.3, ENST00000368662.4, ENST00000368662.5, ENST00000368662.6, ENST00000368662.7, ENST00000368662.8, ENST00000368662.9, NM_016262, Q5H8W8, Q8NEG3, Q9UJT0, TBE_HUMAN, TUBE, uc318gyb.1, uc318gyb.2 UCSC ID: ENST00000368662.10_7 RefSeq Accession: NM_016262.5 Protein: Q9UJT0 (aka TBE_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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