Human Gene TUBE1 (ENST00000368662.10_7) from GENCODE V47lift37
  Description: tubulin epsilon 1 (from RefSeq NM_016262.5)
Gencode Transcript: ENST00000368662.10_7
Gencode Gene: ENSG00000074935.14_9
Transcript (Including UTRs)
   Position: hg19 chr6:112,391,866-112,408,685 Size: 16,820 Total Exon Count: 12 Strand: -
Coding Region
   Position: hg19 chr6:112,392,615-112,408,637 Size: 16,023 Coding Exon Count: 12 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:112,391,866-112,408,685)mRNA (may differ from genome)Protein (475 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: TBE_HUMAN
DESCRIPTION: RecName: Full=Tubulin epsilon chain; AltName: Full=Epsilon-tubulin;
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, centrosome. Note=Associated with pericentriolar material.
SIMILARITY: Belongs to the tubulin family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: TUBE1
Diseases sorted by gene-association score: chronic frontal sinusitis (5), frontal sinusitis (3), laryngeal tuberculosis (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 23.70 RPKM in Brain - Cerebellum
Total median expression: 421.50 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -20.3048-0.423 Picture PostScript Text
3' UTR -131.70749-0.176 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR004057 - Epsilon_tubulin
IPR008280 - Tub_FtsZ_C
IPR000217 - Tubulin
IPR018316 - Tubulin/FtsZ_2-layer-sand-dom
IPR023123 - Tubulin_C
IPR017975 - Tubulin_CS
IPR003008 - Tubulin_FtsZ_GTPase

Pfam Domains:
PF00091 - Tubulin/FtsZ family, GTPase domain
PF03953 - Tubulin C-terminal domain

SCOP Domains:
52490 - Tubulin nucleotide-binding domain-like
55307 - Tubulin C-terminal domain-like

ModBase Predicted Comparative 3D Structure on Q9UJT0
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0003924 GTPase activity
GO:0005200 structural constituent of cytoskeleton
GO:0005525 GTP binding

Biological Process:
GO:0007017 microtubule-based process
GO:0007098 centrosome cycle

Cellular Component:
GO:0000242 pericentriolar material
GO:0005737 cytoplasm
GO:0005815 microtubule organizing center
GO:0005856 cytoskeleton
GO:0005874 microtubule


-  Descriptions from all associated GenBank mRNAs
  BC025405 - Homo sapiens tubulin, epsilon 1, mRNA (cDNA clone MGC:33406 IMAGE:4824105), complete cds.
BC031101 - Homo sapiens tubulin, epsilon 1, mRNA (cDNA clone MGC:33949 IMAGE:5298159), complete cds.
AK026242 - Homo sapiens cDNA: FLJ22589 fis, clone HSI03086, highly similar to AF201334 Homo sapiens epsilon-tubulin mRNA.
JD323357 - Sequence 304381 from Patent EP1572962.
JD224543 - Sequence 205567 from Patent EP1572962.
JD114523 - Sequence 95547 from Patent EP1572962.
JD245546 - Sequence 226570 from Patent EP1572962.
AF201334 - Homo sapiens epsilon-tubulin mRNA, complete cds.
KJ893842 - Synthetic construct Homo sapiens clone ccsbBroadEn_03236 TUBE1 gene, encodes complete protein.
KJ906154 - Synthetic construct Homo sapiens clone ccsbBroadEn_15824 TUBE1 gene, encodes complete protein.
DQ891503 - Synthetic construct clone IMAGE:100004133; FLH177544.01X; RZPDo839B05126D tubulin, epsilon 1 (TUBE1) gene, encodes complete protein.
DQ894695 - Synthetic construct Homo sapiens clone IMAGE:100009155; FLH177540.01L; RZPDo839B05125D tubulin, epsilon 1 (TUBE1) gene, encodes complete protein.
AK126191 - Homo sapiens cDNA FLJ44203 fis, clone THYMU3001083, moderately similar to Tubulin epsilon chain.
CU689114 - Synthetic construct Homo sapiens gateway clone IMAGE:100019572 5' read TUBE1 mRNA.
CU692994 - Synthetic construct Homo sapiens gateway clone IMAGE:100019571 5' read TUBE1 mRNA.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000368662.1, ENST00000368662.2, ENST00000368662.3, ENST00000368662.4, ENST00000368662.5, ENST00000368662.6, ENST00000368662.7, ENST00000368662.8, ENST00000368662.9, NM_016262, Q5H8W8, Q8NEG3, Q9UJT0, TBE_HUMAN, TUBE, uc318gyb.1, uc318gyb.2
UCSC ID: ENST00000368662.10_7
RefSeq Accession: NM_016262.5
Protein: Q9UJT0 (aka TBE_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.