Human Gene TUBB8 (ENST00000568584.6_7) from GENCODE V47lift37 |
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 Sequence and Links to Tools and Databases
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Comments and Description Text from UniProtKB
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ID: TBB8_HUMAN
DESCRIPTION: RecName: Full=Tubulin beta-8 chain;
FUNCTION: Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain (By similarity).
SUBUNIT: Dimer of alpha and beta chains (By similarity).
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton (By similarity).
PTM: Some glutamate residues at the C-terminus are polyglutamylated. This modification occurs exclusively on glutamate residues and results in polyglutamate chains on the gamma-carboxyl group. Also monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella) whereas glutamylation is prevalent in neuronal cells, centrioles, axonemes, and the mitotic spindle. Both modifications can coexist on the same protein on adjacent residues, and lowering glycylation levels increases polyglutamylation, and reciprocally. The precise function of such modifications is still unclear but they regulate the assembly and dynamics of axonemal microtubules (Probable).
SIMILARITY: Belongs to the tubulin family.
SEQUENCE CAUTION: Sequence=CAI16221.1; Type=Erroneous gene model prediction;
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Primer design for this transcript
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MalaCards Disease Associations
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 Common Gene Haplotype Alleles
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Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
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The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
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Protein Domain and Structure Information
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InterPro Domains: Graphical view of domain structure
IPR013838 - Beta-tubulin_BS
IPR002453 - Beta_tubulin
IPR008280 - Tub_FtsZ_C
IPR000217 - Tubulin
IPR018316 - Tubulin/FtsZ_2-layer-sand-dom
IPR023123 - Tubulin_C
IPR017975 - Tubulin_CS
IPR003008 - Tubulin_FtsZ_GTPase
Pfam Domains:
PF00091 - Tubulin/FtsZ family, GTPase domain
PF03953 - Tubulin C-terminal domain
SCOP Domains:
52490 - Tubulin nucleotide-binding domain-like
55307 - Tubulin C-terminal domain-like
ModBase Predicted Comparative 3D Structure on Q3ZCM7
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
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Orthologous Genes in Other Species
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Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
| Mouse | Rat | Zebrafish | D. melanogaster | C. elegans | S. cerevisiae |
| No ortholog | No ortholog | No ortholog | No ortholog | No ortholog | No ortholog |
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Gene Ontology (GO) Annotations with Structured Vocabulary
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Descriptions from all associated GenBank mRNAs
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BC101271 - Homo sapiens tubulin, beta 8, mRNA (cDNA clone IMAGE:40024142), partial cds.
BC156319 - Synthetic construct Homo sapiens clone IMAGE:100061779, MGC:190100 tubulin, beta 8 (TUBB8) mRNA, encodes complete protein.
BC157066 - Synthetic construct Homo sapiens clone IMAGE:100063286, MGC:190729 tubulin, beta 8 (TUBB8) mRNA, encodes complete protein.
JD178727 - Sequence 159751 from Patent EP1572962.
BC101270 - Homo sapiens tubulin, beta 8, mRNA (cDNA clone IMAGE:40024141), partial cds.
JD127872 - Sequence 108896 from Patent EP1572962.
JD142339 - Sequence 123363 from Patent EP1572962.
JD116598 - Sequence 97622 from Patent EP1572962.
DQ574453 - Homo sapiens piRNA piR-42565, complete sequence.
JD427450 - Sequence 408474 from Patent EP1572962.
JD474669 - Sequence 455693 from Patent EP1572962.
JD099390 - Sequence 80414 from Patent EP1572962.
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Biochemical and Signaling Pathways
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Reactome (by CSHL, EBI, and GO)
Protein Q3ZCM7 (Reactome details) participates in the following event(s):
R-HSA-8955706 TTL ligates L-Tyr to the carboxy terminus of alpha-tubulin
R-HSA-8955712 TTCP hydrolyzes the terminal L-Tyr residue from alpha-tubulin
R-HSA-8955332 Carboxyterminal post-translational modifications of tubulin
R-HSA-597592 Post-translational protein modification
R-HSA-392499 Metabolism of proteins
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Other Names for This Gene
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Alternate Gene Symbols: ENST00000568584.1, ENST00000568584.2, ENST00000568584.3, ENST00000568584.4, ENST00000568584.5, NM_177987, Q3ZCM7, Q5SQX9, Q8WZ78, TBB8_HUMAN, TUBB8 , uc325ygv.1, uc325ygv.2
UCSC ID: ENST00000568584.6_7
RefSeq Accession: NM_177987.3
Protein: Q3ZCM7
(aka TBB8_HUMAN)
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Gene Model Information
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for a detailed description of the fields of the table above.
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Methods, Credits, and Use Restrictions
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Click here
for details on how this gene model was made and data restrictions if any.
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US Server
