Human Gene TTC27 (ENST00000317907.9_4) from GENCODE V47lift37
  Description: tetratricopeptide repeat domain 27, transcript variant 1 (from RefSeq NM_017735.5)
Gencode Transcript: ENST00000317907.9_4
Gencode Gene: ENSG00000018699.13_11
Transcript (Including UTRs)
   Position: hg19 chr2:32,853,117-33,046,118 Size: 193,002 Total Exon Count: 20 Strand: +
Coding Region
   Position: hg19 chr2:32,853,360-33,046,005 Size: 192,646 Coding Exon Count: 20 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:32,853,117-33,046,118)mRNA (may differ from genome)Protein (843 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: TTC27_HUMAN
DESCRIPTION: RecName: Full=Tetratricopeptide repeat protein 27; Short=TPR repeat protein 27;
SIMILARITY: Belongs to the TTC27 family.
SIMILARITY: Contains 3 HAT repeats.
SIMILARITY: Contains 7 TPR repeats.
SEQUENCE CAUTION: Sequence=BAA91048.1; Type=Erroneous initiation; Sequence=BAA91315.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 9.60 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 226.15 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -79.40243-0.327 Picture PostScript Text
3' UTR -20.90113-0.185 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR001440 - TPR-1
IPR013026 - TPR-contain_dom
IPR011990 - TPR-like_helical
IPR019734 - TPR_repeat

Pfam Domains:
PF07719 - Tetratricopeptide repeat
PF13181 - Tetratricopeptide repeat
PF13432 - Tetratricopeptide repeat

SCOP Domains:
48340 - Interferon-induced guanylate-binding protein 1 (GBP1), C-terminal domain
48371 - ARM repeat
81901 - HCP-like
48439 - Protein prenylyltransferase
48452 - TPR-like

ModBase Predicted Comparative 3D Structure on Q6P3X3
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologGenome BrowserGenome Browser
Gene DetailsGene Details Gene DetailsGene DetailsGene Details
Gene SorterGene Sorter Gene SorterGene SorterGene Sorter
 RGDEnsembl WormBaseSGD
    Protein SequenceProtein Sequence
    AlignmentAlignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003674 molecular_function

Biological Process:
GO:0008150 biological_process

Cellular Component:
GO:0005575 cellular_component


-  Descriptions from all associated GenBank mRNAs
  AK299196 - Homo sapiens cDNA FLJ57829 complete cds.
BC063791 - Homo sapiens tetratricopeptide repeat domain 27, mRNA (cDNA clone MGC:70550 IMAGE:6500951), complete cds.
AK027570 - Homo sapiens cDNA FLJ14664 fis, clone NT2RP2002880.
KJ899160 - Synthetic construct Homo sapiens clone ccsbBroadEn_08554 TTC27 gene, encodes complete protein.
BC001248 - Homo sapiens tetratricopeptide repeat domain 27, mRNA (cDNA clone IMAGE:3457160), partial cds.
AK000279 - Homo sapiens cDNA FLJ20272 fis, clone HEP01722.
AK225295 - Homo sapiens mRNA for hypothetical protein LOC55622 variant, clone: HEP01722.
AK000665 - Homo sapiens cDNA FLJ20658 fis, clone KAT00985.
JD467519 - Sequence 448543 from Patent EP1572962.
JD551326 - Sequence 532350 from Patent EP1572962.
JD220160 - Sequence 201184 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A6NKJ0, ENST00000317907.1, ENST00000317907.2, ENST00000317907.3, ENST00000317907.4, ENST00000317907.5, ENST00000317907.6, ENST00000317907.7, ENST00000317907.8, NM_017735, Q6P3X3, Q96SS5, Q9BVF1, Q9NWR4, Q9NXG4, TTC27_HUMAN, uc317qit.1, uc317qit.2
UCSC ID: ENST00000317907.9_4
RefSeq Accession: NM_017735.5
Protein: Q6P3X3 (aka TTC27_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.