ID:TSPOA_HUMAN DESCRIPTION: RecName: Full=Translocator protein; AltName: Full=Mitochondrial benzodiazepine receptor; AltName: Full=PKBS; AltName: Full=Peripheral-type benzodiazepine receptor; Short=PBR; FUNCTION: Responsible for the manifestation of peripheral-type benzodiazepine recognition sites and is most likely to comprise binding domains for benzodiazepines and isoquinoline carboxamides. May play a role in the transport of porphyrins and heme. Plays a role in the transport of cholesterol across mitochondrial membranes in steroidogenic cells (By similarity). SUBUNIT: Interacts with BZRAP1 (By similarity). May interact with STAR (By similarity). Interacts with MOST-1. SUBCELLULAR LOCATION: Mitochondrion membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Found in many tissue types. Expressed at the highest levels under normal conditions in tissues that synthesize steroids. SIMILARITY: Belongs to the TspO/BZRP family. WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/bzrp/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P30536
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006626 protein targeting to mitochondrion GO:0006694 steroid biosynthetic process GO:0006700 C21-steroid hormone biosynthetic process GO:0006783 heme biosynthetic process GO:0006811 ion transport GO:0006820 anion transport GO:0006821 chloride transport GO:0006869 lipid transport GO:0006915 apoptotic process GO:0007165 signal transduction GO:0007568 aging GO:0008202 steroid metabolic process GO:0008283 cell proliferation GO:0008347 glial cell migration GO:0010042 response to manganese ion GO:0010266 response to vitamin B1 GO:0010823 negative regulation of mitochondrion organization GO:0010940 positive regulation of necrotic cell death GO:0014012 peripheral nervous system axon regeneration GO:0030301 cholesterol transport GO:0030325 adrenal gland development GO:0031397 negative regulation of protein ubiquitination GO:0032374 regulation of cholesterol transport GO:0032570 response to progesterone GO:0032720 negative regulation of tumor necrosis factor production GO:0033574 response to testosterone GO:0042493 response to drug GO:0043065 positive regulation of apoptotic process GO:0045019 negative regulation of nitric oxide biosynthetic process GO:0048265 response to pain GO:0048266 behavioral response to pain GO:0048678 response to axon injury GO:0050810 regulation of steroid biosynthetic process GO:0051901 positive regulation of mitochondrial depolarization GO:0051928 positive regulation of calcium ion transport GO:0060242 contact inhibition GO:0060252 positive regulation of glial cell proliferation GO:0060253 negative regulation of glial cell proliferation GO:0071222 cellular response to lipopolysaccharide GO:0071294 cellular response to zinc ion GO:0071476 cellular hypotonic response GO:0072655 establishment of protein localization to mitochondrion GO:0072656 maintenance of protein location in mitochondrion GO:1903147 negative regulation of mitophagy GO:1903579 negative regulation of ATP metabolic process GO:2000379 positive regulation of reactive oxygen species metabolic process