ID:TRI63_HUMAN DESCRIPTION: RecName: Full=E3 ubiquitin-protein ligase TRIM63; EC=6.3.2.-; AltName: Full=Iris RING finger protein; AltName: Full=Muscle-specific RING finger protein 1; Short=MuRF-1; Short=MuRF1; AltName: Full=RING finger protein 28; AltName: Full=Striated muscle RING zinc finger protein; AltName: Full=Tripartite motif-containing protein 63; FUNCTION: E3 ubiquitin ligase. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric- associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells. PATHWAY: Protein modification; protein ubiquitination. SUBUNIT: Homooligomer and heterooligomer. Interacts with SUMO2, titin/TTN and GMEB1. Interacts with TRIM54 and probably with TRIM55 and TNNI3. Forms a ternary complex with GNB2L1 and PRKCE (By similarity). SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By similarity). Note=Localizes to the M- and Z-lines in skeletal muscle. Colocalizes with TNNI3 in myocytes (By similarity). TISSUE SPECIFICITY: Muscle specific. Selectively expressed in heart and skeletal muscle. Also expressed in the iris. DEVELOPMENTAL STAGE: Expressed throughout all developmental stages. DOMAIN: The RING-type zinc finger mediates interaction with SUMO2 and localization to the nucleus. Also required for the E3 ubiquitin ligase activity (By similarity). SIMILARITY: Contains 1 B box-type zinc finger. SIMILARITY: Contains 1 COS domain. SIMILARITY: Contains 1 RING-type zinc finger. CAUTION: It is uncertain whether Met-1 or Met-14 is the initiator. SEQUENCE CAUTION: Sequence=AAK52497.1; Type=Frameshift; Positions=Several; Sequence=AAK52497.1; Type=Miscellaneous discrepancy; Note=Sequencing errors; Sequence=CAC33173.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q969Q1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AJ276484 - Human mRNA for muscle specific RING finger 2 (MURF2) protein (MURF2 gene). BC080529 - Homo sapiens tripartite motif-containing 63, mRNA (cDNA clone MGC:99548 IMAGE:4862321), complete cds. AF353673 - Homo sapiens iris ring finger protein mRNA, complete cds. AJ291713 - Homo sapiens mRNA for RNF28 gene for ring finger protein 28. AK056942 - Homo sapiens cDNA FLJ32380 fis, clone SKMUS1000064, moderately similar to Mus musculus RING-finger protein MURF mRNA. AF361946 - Homo sapiens striated muscle RING zinc finger protein SMRZ mRNA, complete cds. JD452797 - Sequence 433821 from Patent EP1572962. JD207365 - Sequence 188389 from Patent EP1572962. JD164296 - Sequence 145320 from Patent EP1572962. JD368538 - Sequence 349562 from Patent EP1572962. JD546662 - Sequence 527686 from Patent EP1572962. AK297820 - Homo sapiens cDNA FLJ50813 complete cds, highly similar to Ubiquitin ligase TRIM63 (EC 6.3.2.-). JD391005 - Sequence 372029 from Patent EP1572962. JD330254 - Sequence 311278 from Patent EP1572962. BT007373 - Homo sapiens ring finger protein 28 mRNA, complete cds. BC015717 - Homo sapiens tripartite motif-containing 63, mRNA (cDNA clone IMAGE:3922363), **** WARNING: chimeric clone ****. JD499362 - Sequence 480386 from Patent EP1572962. JD301144 - Sequence 282168 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q969Q1 (Reactome details) participates in the following event(s):
R-HSA-983157 Interaction of E3 with substrate and E2-Ub complex R-HSA-983147 Release of E3 from polyubiquitinated substrate R-HSA-983140 Transfer of Ub from E2 to substrate and release of E2 R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation R-HSA-983169 Class I MHC mediated antigen processing & presentation R-HSA-1280218 Adaptive Immune System R-HSA-168256 Immune System
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
