ID:TRIA1_HUMAN DESCRIPTION: RecName: Full=TP53-regulated inhibitor of apoptosis 1; AltName: Full=Protein 15E1.1; AltName: Full=WF-1; AltName: Full=p53-inducible cell-survival factor; Short=p53CSV; FUNCTION: Mediates cell survival by inhibiting activation of caspase-9 which prevents induction of apoptosis. SUBUNIT: Interacts with APAF1 and HSP70. SUBCELLULAR LOCATION: Cytoplasm, perinuclear region. INDUCTION: In p53/TP53-dependent manner in response to low levels of DNA damage. Not induced when DNA damage is severe. SIMILARITY: Belongs to the TRIAP1/MDM35 family. SEQUENCE CAUTION: Sequence=AAR00584.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF05254 - Uncharacterised protein family (UPF0203)
SCOP Domains: 47072 - Cysteine alpha-hairpin motif 81531 - Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)
ModBase Predicted Comparative 3D Structure on O43715
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006869 lipid transport GO:0006915 apoptotic process GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest GO:0015914 phospholipid transport GO:0030330 DNA damage response, signal transduction by p53 class mediator GO:0034644 cellular response to UV GO:0042981 regulation of apoptotic process GO:0043066 negative regulation of apoptotic process GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0090201 negative regulation of release of cytochrome c from mitochondria GO:0097035 regulation of membrane lipid distribution GO:1902166 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:2001140 positive regulation of phospholipid transport
Protein O43715 (Reactome details) participates in the following event(s):
R-HSA-6801242 TRIAP1 binds PRELID1, PRELID3A R-HSA-6801250 TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane R-HSA-6803204 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release R-HSA-5633008 TP53 Regulates Transcription of Cell Death Genes R-HSA-3700989 Transcriptional Regulation by TP53 R-HSA-212436 Generic Transcription Pathway R-HSA-73857 RNA Polymerase II Transcription R-HSA-74160 Gene expression (Transcription)
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
