Human Gene TRAM1 (ENST00000262213.7_7) from GENCODE V47lift37

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Description: translocation associated membrane protein 1, transcript variant 1 (from RefSeq NM_014294.6)
Gencode Transcript: ENST00000262213.7_7
Gencode Gene: ENSG00000067167.8_9
Transcript (Including UTRs)
Position: hg19 chr8:71,485,453-71,520,651 Size: 35,199 Total Exon Count: 11 Strand: -
Coding Region
Position: hg19 chr8:71,487,167-71,520,434 Size: 33,268 Coding Exon Count: 11

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr8:71,485,453-71,520,651)			mRNA (may differ from genome)		Protein (374 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	OMIM	PubMed	UniProtKB	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: Q6FHL3_HUMAN DESCRIPTION: SubName: Full=TRAM1 protein; SubName: Full=Translocating chain-associating membrane protein; SubName: Full=Translocation associated membrane protein 1, isoform CRA_b; SubName: Full=cDNA FLJ78414, highly similar to Homo sapiens translocation associated membrane protein 1 (TRAM1), mRNA; SIMILARITY: Contains 1 TLC (TRAM/LAG1/CLN8) domain.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D004958 Estradiol C111118 2',3,3',4',5-pentachloro-4-hydroxybiphenyl C049584 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine C009505 4,4'-diaminodiphenylmethane D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide C547126 AZM551248 D017632 Asbestos, Serpentine D001564 Benzo(a)pyrene D001647 Bile Acids and Salts D002945 Cisplatin more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 135.03 RPKM in Cells - Cultured fibroblasts Total median expression: 1020.45 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-106.50	217	-0.491	Picture	PostScript	Text
3' UTR	-362.50	1714	-0.211	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR006634 - TLC-dom
IPR013599 - TRAM1
IPR016447 - Translocation_assoc_membrane

Pfam Domains:
PF03798 - TLC domain
PF08390 - TRAM1-like protein

ModBase Predicted Comparative 3D Structure on Q6FHL3


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	Genome Browser	No ortholog
Gene Details	Gene Details		Gene Details	Gene Details
Gene Sorter	Gene Sorter		Gene Sorter	Gene Sorter
	RGD	Ensembl		WormBase
				Protein Sequence
				Alignment

Gene Ontology (GO) Annotations with Structured Vocabulary


	Biological Process: GO:0015031 protein transport Cellular Component: GO:0016020 membrane GO:0016021 integral component of membrane

Descriptions from all associated GenBank mRNAs


	LF205144 - JP 2014500723-A/12647: Polycomb-Associated Non-Coding RNAs. BC037738 - Homo sapiens translocation associated membrane protein 1, mRNA (cDNA clone MGC:33851 IMAGE:5261490), complete cds. BC032018 - Homo sapiens translocation associated membrane protein 1, mRNA (cDNA clone IMAGE:4822011), with apparent retained intron. BC000687 - Homo sapiens translocation associated membrane protein 1, mRNA (cDNA clone MGC:784 IMAGE:3347823), complete cds. AF274933 - Homo sapiens PNAS-8 mRNA, partial sequence. JD206477 - Sequence 187501 from Patent EP1572962. LF317056 - JP 2014500723-A/124559: Polycomb-Associated Non-Coding RNAs. JD562524 - Sequence 543548 from Patent EP1572962. LF317057 - JP 2014500723-A/124560: Polycomb-Associated Non-Coding RNAs. LF317058 - JP 2014500723-A/124561: Polycomb-Associated Non-Coding RNAs. LF317059 - JP 2014500723-A/124562: Polycomb-Associated Non-Coding RNAs. JD552009 - Sequence 533033 from Patent EP1572962. AK289397 - Homo sapiens cDNA FLJ75031 complete cds, highly similar to Homo sapiens translocation associated membrane protein 1 (TRAM1), mRNA. LF317060 - JP 2014500723-A/124563: Polycomb-Associated Non-Coding RNAs. BC020283 - Homo sapiens translocation associated membrane protein 1, mRNA (cDNA clone IMAGE:4519858). AK292777 - Homo sapiens cDNA FLJ78414 complete cds, highly similar to Homo sapiens translocation associated membrane protein 1 (TRAM1), mRNA. JD370922 - Sequence 351946 from Patent EP1572962. AK303411 - Homo sapiens cDNA FLJ53588 complete cds, highly similar to Translocation-associated membrane protein 1. X63679 - H.sapiens mRNA for TRAMP protein. LF317061 - JP 2014500723-A/124564: Polycomb-Associated Non-Coding RNAs. CR541739 - Homo sapiens full open reading frame cDNA clone RZPDo834F0429D for gene TRAM1, translocation associated membrane protein 1; complete cds, incl. stopcodon. BT007359 - Homo sapiens translocating chain-associating membrane protein mRNA, complete cds. KJ893379 - Synthetic construct Homo sapiens clone ccsbBroadEn_02773 TRAM1 gene, encodes complete protein. DQ892688 - Synthetic construct clone IMAGE:100005318; FLH188887.01X; RZPDo839H0273D translocation associated membrane protein 1 (TRAM1) gene, encodes complete protein. DQ895932 - Synthetic construct Homo sapiens clone IMAGE:100010392; FLH188883.01L; RZPDo839H0263D translocation associated membrane protein 1 (TRAM1) gene, encodes complete protein. CR541654 - Homo sapiens full open reading frame cDNA clone RZPDo834B0827D for gene TRAM1, translocation associated membrane protein 1; complete cds, without stopcodon. JD031870 - Sequence 12894 from Patent EP1572962. JD027501 - Sequence 8525 from Patent EP1572962. LF317062 - JP 2014500723-A/124565: Polycomb-Associated Non-Coding RNAs. LF317067 - JP 2014500723-A/124570: Polycomb-Associated Non-Coding RNAs. LF317068 - JP 2014500723-A/124571: Polycomb-Associated Non-Coding RNAs. LF317071 - JP 2014500723-A/124574: Polycomb-Associated Non-Coding RNAs. JD080044 - Sequence 61068 from Patent EP1572962. JD460917 - Sequence 441941 from Patent EP1572962. JD159945 - Sequence 140969 from Patent EP1572962. LF317072 - JP 2014500723-A/124575: Polycomb-Associated Non-Coding RNAs. MA440721 - JP 2018138019-A/12647: Polycomb-Associated Non-Coding RNAs. MA552633 - JP 2018138019-A/124559: Polycomb-Associated Non-Coding RNAs. MA552634 - JP 2018138019-A/124560: Polycomb-Associated Non-Coding RNAs. MA552635 - JP 2018138019-A/124561: Polycomb-Associated Non-Coding RNAs. MA552636 - JP 2018138019-A/124562: Polycomb-Associated Non-Coding RNAs. MA552637 - JP 2018138019-A/124563: Polycomb-Associated Non-Coding RNAs. MA552638 - JP 2018138019-A/124564: Polycomb-Associated Non-Coding RNAs. MA552639 - JP 2018138019-A/124565: Polycomb-Associated Non-Coding RNAs. MA552644 - JP 2018138019-A/124570: Polycomb-Associated Non-Coding RNAs. MA552645 - JP 2018138019-A/124571: Polycomb-Associated Non-Coding RNAs. MA552648 - JP 2018138019-A/124574: Polycomb-Associated Non-Coding RNAs. MA552649 - JP 2018138019-A/124575: Polycomb-Associated Non-Coding RNAs.

Other Names for This Gene


	Alternate Gene Symbols: ENST00000262213.1, ENST00000262213.2, ENST00000262213.3, ENST00000262213.4, ENST00000262213.5, ENST00000262213.6, hCG_18447 , NM_014294, Q6FHL3, Q6FHL3_HUMAN, TRAM1 , uc317gxz.1, uc317gxz.2 UCSC ID: ENST00000262213.7_7 RefSeq Accession: NM_014294.6 Protein: Q6FHL3

Gene Model Information


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Methods, Credits, and Use Restrictions


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