ID:TPX2_HUMAN DESCRIPTION: RecName: Full=Targeting protein for Xklp2; AltName: Full=Differentially expressed in cancerous and non-cancerous lung cells 2; Short=DIL-2; AltName: Full=Hepatocellular carcinoma-associated antigen 519; AltName: Full=Protein fls353; AltName: Full=Restricted expression proliferation-associated protein 100; Short=p100; FUNCTION: Spindle assembly factor. Required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules. Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation. SUBUNIT: Interacts with AURKA. INTERACTION: P62993:GRB2; NbExp=2; IntAct=EBI-1037322, EBI-401755; P16333:NCK1; NbExp=4; IntAct=EBI-1037322, EBI-389883; P27986:PIK3R1; NbExp=2; IntAct=EBI-1037322, EBI-79464; SUBCELLULAR LOCATION: Nucleus. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, spindle pole. Note=During mitosis it is strictly associated with the spindle pole and with the mitotic spindle, whereas during S and G2, it is diffusely distributed throughout the nucleus. Is released from the nucleus in apoptotic cells and is detected on apoptotic microtubules. TISSUE SPECIFICITY: Expressed in lung carcinoma cell lines but not in normal lung tissues. DEVELOPMENTAL STAGE: Exclusively expressed in proliferating cells from the transition G1/S until the end of cytokinesis. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Belongs to the TPX2 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9ULW0
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
