Human Gene TPRKB (ENST00000272424.11_8) from GENCODE V47lift37

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Description: TP53RK binding protein, transcript variant 5 (from RefSeq NM_016058.5)
Gencode Transcript: ENST00000272424.11_8
Gencode Gene: ENSG00000144034.16_10
Transcript (Including UTRs)
Position: hg19 chr2:73,957,000-73,964,472 Size: 7,473 Total Exon Count: 5 Strand: -
Coding Region
Position: hg19 chr2:73,957,070-73,961,696 Size: 4,627 Coding Exon Count: 4

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr2:73,957,000-73,964,472)			mRNA (may differ from genome)		Protein (175 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	OMIM	PubMed	Reactome	UniProtKB
BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: TPRKB_HUMAN DESCRIPTION: RecName: Full=TP53RK-binding protein; AltName: Full=PRPK-binding protein; SUBUNIT: Interacts with TP53RK/PRPK. SUBCELLULAR LOCATION: Cytoplasm. Nucleus. TISSUE SPECIFICITY: Widely expressed. SIMILARITY: Belongs to the CGI121/TPRKB family.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene C111118 2',3,3',4',5-pentachloro-4-hydroxybiphenyl D016604 Aflatoxin B1 D001564 Benzo(a)pyrene D003300 Copper D004958 Estradiol D018038 Sodium Selenite D013749 Tetrachlorodibenzodioxin D014635 Valproic Acid C039281 furan C006253 pirinixic acid

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 22.53 RPKM in Testis Total median expression: 474.12 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-24.40	66	-0.370	Picture	PostScript	Text
3' UTR	-4.70	70	-0.067	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR013926 - Kinase-bd_CGI-121

Pfam Domains:
PF08617 - Kinase binding protein CGI-121

SCOP Domains:
56399 - ADP-ribosylation
143870 - PF0523-like

Protein Data Bank (PDB) 3-D Structure
MuPIT help

3ENP - X-ray MuPIT

ModBase Predicted Comparative 3D Structure on Q9Y3C4


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	Genome Browser	Genome Browser
Gene Details				Gene Details	Gene Details
Gene Sorter				Gene Sorter	Gene Sorter
		Ensembl		WormBase	SGD
				Protein Sequence	Protein Sequence
				Alignment	Alignment

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0005515 protein binding GO:0019901 protein kinase binding Biological Process: GO:0002949 tRNA threonylcarbamoyladenosine modification GO:0008033 tRNA processing Cellular Component: GO:0000408 EKC/KEOPS complex GO:0005634 nucleus GO:0005737 cytoplasm GO:0005829 cytosol

Descriptions from all associated GenBank mRNAs


	AK295239 - Homo sapiens cDNA FLJ59202 complete cds, moderately similar to Homo sapiens CGI-121 protein (CGI-121), mRNA. BC018180 - Homo sapiens cDNA clone IMAGE:3861754, ** WARNING: chimeric clone **. AF151879 - Homo sapiens CGI-121 protein mRNA, complete cds. AK291071 - Homo sapiens cDNA FLJ76394 complete cds, highly similar to Homo sapiens CGI-121 protein (CGI-121), mRNA. AK097254 - Homo sapiens cDNA FLJ39935 fis, clone SPLEN2021463. AF060921 - Homo sapiens clone 016h06 My019 protein mRNA, complete cds. BC029492 - Homo sapiens TP53RK binding protein, mRNA (cDNA clone MGC:33031 IMAGE:5271898), complete cds. AY157986 - Homo sapiens CGI-121 L1 isoform mRNA, complete cds, alternatively spliced. AY157987 - Homo sapiens CGI-121 S1 isoform mRNA, complete cds, alternatively spliced. KJ904737 - Synthetic construct Homo sapiens clone ccsbBroadEn_14131 TPRKB-like gene, encodes complete protein. AB587435 - Synthetic construct DNA, clone: pF1KB6961, Homo sapiens TPRKB gene for TP53RK binding protein, without stop codon, in Flexi system. AY643713 - Homo sapiens CGI-121 mRNA, complete cds, alternatively spliced.

Biochemical and Signaling Pathways


	Reactome (by CSHL, EBI, and GO) Protein Q9Y3C4 (Reactome details) participates in the following event(s): R-HSA-6784494 EKC complex threonylcarbamoylates A37 of tRNAs R-HSA-6782315 tRNA modification in the nucleus and cytosol R-HSA-72306 tRNA processing R-HSA-8953854 Metabolism of RNA

Other Names for This Gene


	Alternate Gene Symbols: CGI-121 , D6W5H6, ENST00000272424.1, ENST00000272424.10, ENST00000272424.2, ENST00000272424.3, ENST00000272424.4, ENST00000272424.5, ENST00000272424.6, ENST00000272424.7, ENST00000272424.8, ENST00000272424.9, My019, NM_016058, Q8IWR6, Q8IWR7, Q9H3K4, Q9Y3C4, TPRKB , TPRKB_HUMAN, uc317iyu.1, uc317iyu.2 UCSC ID: ENST00000272424.11_8 RefSeq Accession: NM_016058.5 Protein: Q9Y3C4 (aka TPRKB_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


	Click here for details on how this gene model was made and data restrictions if any.