ID:TM1L2_HUMAN DESCRIPTION: RecName: Full=TOM1-like protein 2; AltName: Full=Target of Myb-like protein 2; FUNCTION: Probable role in protein transport. May regulate growth factor-induced mitogenic signaling. SUBUNIT: Interacts with clathrin, SRC and TOLLIP. TISSUE SPECIFICITY: Ubiquitously expressed with higher expression in heart and skeletal muscle. DOMAIN: The GAT domain mediates interaction with TOLLIP. SIMILARITY: Belongs to the TOM1 family. SIMILARITY: Contains 1 GAT domain. SIMILARITY: Contains 1 VHS domain. SEQUENCE CAUTION: Sequence=AAL78338.1; Type=Frameshift; Positions=101, 121, 170;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q6ZVM7
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006886 intracellular protein transport GO:0007165 signal transduction GO:0015031 protein transport GO:0045839 negative regulation of mitotic nuclear division