ID:TM1L1_HUMAN DESCRIPTION: RecName: Full=TOM1-like protein 1; AltName: Full=Src-activating and signaling molecule protein; AltName: Full=Target of Myb-like protein 1; FUNCTION: Probable adapter protein involved in signaling pathways. Interacts with the SH2 and SH3 domains of various signaling proteins when it is phosphorylated. May promote FYN activation, possibly by disrupting intramolecular SH3-dependent interactions (By similarity). SUBUNIT: Interacts with FYN, GRB2 and PIK3R1 when phosphorylated (By similarity). Interacts with LYN (By similarity). INTERACTION: Q9H0E2:TOLLIP; NbExp=3; IntAct=EBI-712991, EBI-74615; P52735:VAV2; NbExp=2; IntAct=EBI-712991, EBI-297549; SUBCELLULAR LOCATION: Golgi apparatus, Golgi stack. Endosome membrane (Potential). Cytoplasm (By similarity). Membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Note=A small proportion is membrane-associated (By similarity). PTM: Phosphorylated on tyrosines by FYN and LYN (By similarity). Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Belongs to the TOM1 family. SIMILARITY: Contains 1 GAT domain. SIMILARITY: Contains 1 VHS domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O75674
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006886 intracellular protein transport GO:0007165 signal transduction GO:0015031 protein transport GO:0031954 positive regulation of protein autophosphorylation GO:0032147 activation of protein kinase activity GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway GO:0045839 negative regulation of mitotic nuclear division GO:2000278 regulation of DNA biosynthetic process
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
