Human Gene TNK2 (ENST00000672887.2_8) from GENCODE V47lift37

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Description: tyrosine kinase non receptor 2, transcript variant 34 (from RefSeq NR_170687.1)
Gencode Transcript: ENST00000672887.2_8
Gencode Gene: ENSG00000061938.21_22
Transcript (Including UTRs)
Position: hg19 chr3:195,590,235-195,635,422 Size: 45,188 Total Exon Count: 16 Strand: -
Coding Region
Position: hg19 chr3:195,591,052-195,615,459 Size: 24,408 Coding Exon Count: 15

Page Index	Sequence and Links	Primers	MalaCards	CTD	Gene Alleles
Microarray Expression	RNA Structure	Other Species	mRNA Descriptions	Other Names	Model Information
Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr3:195,590,235-195,635,422)			mRNA (may differ from genome)		Protein (1055 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	ExonPrimer	GeneCards	HGNC
Malacards	MGI	PubMed	UniProtKB	Wikipedia

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: TNK2 Diseases sorted by gene-association score: infantile-onset mesial temporal lobe epilepsy with severe cognitive regression* (350) * = Manually curated disease association

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D004997 Ethinyl Estradiol D015632 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine C016403 2,4-dinitrotoluene C547126 AZM551248 D000082 Acetaminophen D016604 Aflatoxin B1 D002104 Cadmium D002110 Caffeine D002794 Choline D002994 Clofibrate D019327 Copper Sulfate D003993 Dibutyl Phthalate D004054 Diethylstilbestrol D005419 Flavonoids D005492 Folic Acid D005944 Glucosamine D008715 Methionine D008748 Methylcholanthrene D009538 Nicotine D010634 Phenobarbital D010936 Plant Extracts D059808 Polyphenols D011748 Pyrogallol D012969 Sodium Fluoride D013749 Tetrachlorodibenzodioxin D014635 Valproic Acid C044887 beta-methylcholine C059514 resveratrol

Common Gene Haplotype Alleles


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Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-49.90	85	-0.587	Picture	PostScript	Text
3' UTR	-391.30	817	-0.479	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Descriptions from all associated GenBank mRNAs


	BC008884 - Homo sapiens tyrosine kinase, non-receptor, 2, mRNA (cDNA clone IMAGE:4302390), complete cds. L13738 - Homo sapiens activated p21cdc42Hs kinase (ACK1) mRNA, complete cds. AK126712 - Homo sapiens cDNA FLJ44758 fis, clone BRACE3031315, moderately similar to Homo sapiens activated p21cdc42Hs kinase (ACK1). AK127455 - Homo sapiens cDNA FLJ45547 fis, clone BRTHA2035743, highly similar to Activated CDC42 kinase 1 (EC 2.7.10.2). AK225786 - Homo sapiens mRNA for tyrosine kinase, non-receptor, 2 isoform 2 variant, clone: FCC131H03. AK131539 - Homo sapiens cDNA FLJ16772 fis, clone BRAWH3043827, highly similar to Homo sapiens activated p21cdc42Hs kinase (ACK1). JD273585 - Sequence 254609 from Patent EP1572962. JD375274 - Sequence 356298 from Patent EP1572962. JD142695 - Sequence 123719 from Patent EP1572962. JD164067 - Sequence 145091 from Patent EP1572962. JD158088 - Sequence 139112 from Patent EP1572962. JD168108 - Sequence 149132 from Patent EP1572962. JD087219 - Sequence 68243 from Patent EP1572962. JD203379 - Sequence 184403 from Patent EP1572962. JD183167 - Sequence 164191 from Patent EP1572962. JD107448 - Sequence 88472 from Patent EP1572962. JD157742 - Sequence 138766 from Patent EP1572962. JD173048 - Sequence 154072 from Patent EP1572962. JD264799 - Sequence 245823 from Patent EP1572962. JD510821 - Sequence 491845 from Patent EP1572962. JD198254 - Sequence 179278 from Patent EP1572962. JD519158 - Sequence 500182 from Patent EP1572962. JD342026 - Sequence 323050 from Patent EP1572962. JD385047 - Sequence 366071 from Patent EP1572962. JD176085 - Sequence 157109 from Patent EP1572962. BC156798 - Synthetic construct Homo sapiens clone IMAGE:100062521, MGC:190540 tyrosine kinase, non-receptor, 2 (TNK2) mRNA, encodes complete protein. BC020389 - Homo sapiens tyrosine kinase, non-receptor, 2, mRNA (cDNA clone IMAGE:4158259). BC028164 - Homo sapiens tyrosine kinase, non-receptor, 2, mRNA (cDNA clone IMAGE:5246061), complete cds. AB209338 - Homo sapiens mRNA for Hypothetical protein FLJ16772 variant protein. KJ902072 - Synthetic construct Homo sapiens clone ccsbBroadEn_11466 TNK2 gene, encodes complete protein. AK309332 - Homo sapiens cDNA, FLJ99373. CU688416 - Synthetic construct Homo sapiens gateway clone IMAGE:100019781 5' read TNK2 mRNA. AK024904 - Homo sapiens cDNA: FLJ21251 fis, clone COL01259. DQ596952 - Homo sapiens piRNA piR-35018, complete sequence. JD186081 - Sequence 167105 from Patent EP1572962. JD342032 - Sequence 323056 from Patent EP1572962. JD186418 - Sequence 167442 from Patent EP1572962. JD322342 - Sequence 303366 from Patent EP1572962. JD170052 - Sequence 151076 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: A0A5F9ZGX5, A0A5F9ZGX5_HUMAN, ENST00000672887.1, NR_170687, TNK2 , uc329wun.1, uc329wun.2 UCSC ID: ENST00000672887.2_8 RefSeq Accession: NM_001382273.1

Gene Model Information


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Methods, Credits, and Use Restrictions


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