Human Gene TNFSF12 (ENST00000293825.11_7) from GENCODE V47lift37

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Description: TNF superfamily member 12, transcript variant 1 (from RefSeq NM_003809.3)
Gencode Transcript: ENST00000293825.11_7
Gencode Gene: ENSG00000239697.12_12
Transcript (Including UTRs)
Position: hg19 chr17:7,452,375-7,461,198 Size: 8,824 Total Exon Count: 7 Strand: +
Coding Region
Position: hg19 chr17:7,452,471-7,460,667 Size: 8,197 Coding Exon Count: 7

Page Index	Sequence and Links	Primers	MalaCards	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr17:7,452,375-7,461,198)			mRNA (may differ from genome)		Protein (249 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Malacards	MGI	OMIM	PubMed	UniProtKB
Wikipedia	BioGrid CRISPR DB

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: TNFSF12 Diseases sorted by gene-association score: common variable immunodeficiency* (107), hemophagocytic lymphohistiocytosis (1) * = Manually curated disease association

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D004958 Estradiol D013749 Tetrachlorodibenzodioxin C504897 12-(3-adamantan-1-ylureido)dodecanoic acid C548651 2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester D000082 Acetaminophen C068073 Am 580 D020111 Chlorodiphenyl (54% Chlorine) D002922 Ciguatoxins D003035 Cobalt D000242 Cyclic AMP more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 72.99 RPKM in Artery - Aorta Total median expression: 1746.12 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-47.70	96	-0.497	Picture	PostScript	Text
3' UTR	-161.20	531	-0.304	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR006052 - TNF
IPR008983 - Tumour_necrosis_fac-like

Pfam Domains:
PF00229 - TNF(Tumour Necrosis Factor) family

SCOP Domains:
49842 - TNF-like

ModBase Predicted Comparative 3D Structure on Q4ACW9


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0005164 tumor necrosis factor receptor binding GO:0005515 protein binding Biological Process: GO:0006955 immune response GO:0097191 extrinsic apoptotic signaling pathway Cellular Component: GO:0005576 extracellular region GO:0016020 membrane

Descriptions from all associated GenBank mRNAs


	BC019047 - Homo sapiens tumor necrosis factor (ligand) superfamily, member 12, mRNA (cDNA clone MGC:20669 IMAGE:4766071), complete cds. BC071837 - Homo sapiens tumor necrosis factor (ligand) superfamily, member 12, mRNA (cDNA clone MGC:88497 IMAGE:5934943), complete cds. AF055872 - Homo sapiens Apo3/DR3 ligand (APO3L) mRNA, complete cds. AY358870 - Homo sapiens clone DNA30879 Apo-3 Ligand (UNQ181) mRNA, complete cds. AY081051 - Homo sapiens TWE-PRIL mRNA, complete cds. BC104420 - Homo sapiens tumor necrosis factor (ligand) superfamily, member 12, mRNA (cDNA clone MGC:129581 IMAGE:40004935), complete cds. AF030099 - Homo sapiens TWEAK mRNA, complete cds. BC156811 - Synthetic construct Homo sapiens clone IMAGE:100062583, MGC:190573 TNFSF12-TNFSF13 readthrough transcript (TNFSF12-TNFSF13) mRNA, encodes complete protein. KJ897899 - Synthetic construct Homo sapiens clone ccsbBroadEn_07293 TNFSF12 gene, encodes complete protein. JF432764 - Synthetic construct Homo sapiens clone IMAGE:100074008 tumor necrosis factor (ligand) superfamily, member 12 (TNFSF12) gene, encodes complete protein. KJ900835 - Synthetic construct Homo sapiens clone ccsbBroadEn_10229 TNFSF12 gene, encodes complete protein. JD329264 - Sequence 310288 from Patent EP1572962. JD243067 - Sequence 224091 from Patent EP1572962. CQ873846 - Sequence 265 from Patent WO2004076622. DD413683 - Regulation of Mammalian Cells. JD513765 - Sequence 494789 from Patent EP1572962. JD207404 - Sequence 188428 from Patent EP1572962. JD276327 - Sequence 257351 from Patent EP1572962. JD326644 - Sequence 307668 from Patent EP1572962. JD326645 - Sequence 307669 from Patent EP1572962. JD390737 - Sequence 371761 from Patent EP1572962. JD126786 - Sequence 107810 from Patent EP1572962. JD322600 - Sequence 303624 from Patent EP1572962. JD528345 - Sequence 509369 from Patent EP1572962. JD116101 - Sequence 97125 from Patent EP1572962. JD386628 - Sequence 367652 from Patent EP1572962. JD418296 - Sequence 399320 from Patent EP1572962. JD391018 - Sequence 372042 from Patent EP1572962. JD401215 - Sequence 382239 from Patent EP1572962. JD188537 - Sequence 169561 from Patent EP1572962. JD358013 - Sequence 339037 from Patent EP1572962.

Biochemical and Signaling Pathways


	BioCarta from NCI Cancer Genome Anatomy Project h_tall1Pathway - TACI and BCMA stimulation of B cell immune responses.

Other Names for This Gene


	Alternate Gene Symbols: ENST00000293825.1, ENST00000293825.10, ENST00000293825.2, ENST00000293825.3, ENST00000293825.4, ENST00000293825.5, ENST00000293825.6, ENST00000293825.7, ENST00000293825.8, ENST00000293825.9, hCG_1991317 , NM_003809, Q4ACW9, Q4ACW9_HUMAN, TNFSF12 , TWEAK , uc317lev.1, uc317lev.2 UCSC ID: ENST00000293825.11_7 RefSeq Accession: NM_003809.3 Protein: Q4ACW9

Gene Model Information


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Methods, Credits, and Use Restrictions


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