Human Gene TNFRSF25 (ENST00000356876.8_10) from GENCODE V47lift37

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Description: TNF receptor superfamily member 25, transcript variant 2 (from RefSeq NM_003790.3)
Gencode Transcript: ENST00000356876.8_10
Gencode Gene: ENSG00000215788.11_19
Transcript (Including UTRs)
Position: hg19 chr1:6,520,846-6,526,233 Size: 5,388 Total Exon Count: 10 Strand: -
Coding Region
Position: hg19 chr1:6,521,494-6,526,167 Size: 4,674 Coding Exon Count: 10

Page Index	Sequence and Links	UniProtKB Comments	Primers	MalaCards	CTD
Gene Alleles	RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species
GO Annotations	mRNA Descriptions	Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr1:6,520,846-6,526,233)			mRNA (may differ from genome)		Protein (417 aa)
Gene Sorter	Genome Browser	Other Species FASTA	Gene interactions	Table Schema	AlphaFold
BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards	HGNC
Malacards	MGI	OMIM	PubMed	Reactome	UniProtKB
Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: TNR25_HUMAN DESCRIPTION: RecName: Full=Tumor necrosis factor receptor superfamily member 25; AltName: Full=Apo-3; AltName: Full=Apoptosis-inducing receptor AIR; AltName: Full=Apoptosis-mediating receptor DR3; AltName: Full=Apoptosis-mediating receptor TRAMP; AltName: Full=Death receptor 3; AltName: Full=Lymphocyte-associated receptor of death; Short=LARD; AltName: Full=Protein WSL; AltName: Full=Protein WSL-1; Flags: Precursor; FUNCTION: Receptor for TNFSF12/APO3L/TWEAK. Interacts directly with the adapter TRADD. Mediates activation of NF-kappa-B and induces apoptosis. May play a role in regulating lymphocyte homeostasis. SUBUNIT: Homodimer. Interacts strongly via the death domains with TNFRSF1 and TRADD to activate at least two distinct signaling cascades, apoptosis and NF-kappa-B signaling. Interacts with BAG4. SUBCELLULAR LOCATION: Isoform 1: Cell membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: Isoform 2: Cell membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: Isoform 9: Cell membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: Isoform 11: Cell membrane; Single-pass type I membrane protein. SUBCELLULAR LOCATION: Isoform 3: Secreted. SUBCELLULAR LOCATION: Isoform 4: Secreted. SUBCELLULAR LOCATION: Isoform 5: Secreted. SUBCELLULAR LOCATION: Isoform 6: Secreted. SUBCELLULAR LOCATION: Isoform 7: Secreted. SUBCELLULAR LOCATION: Isoform 8: Secreted. SUBCELLULAR LOCATION: Isoform 10: Secreted. SUBCELLULAR LOCATION: Isoform 12: Secreted. TISSUE SPECIFICITY: Abundantly expressed in thymocytes and lymphocytes. Detected in lymphocyte-rich tissues such as thymus, colon, intestine, and spleen. Also found in the prostate. PTM: Glycosylated (Probable). SIMILARITY: Contains 1 death domain. SIMILARITY: Contains 4 TNFR-Cys repeats. WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/tnfrsf25/";

Primer design for this transcript

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Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
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To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: TNFRSF25 Diseases sorted by gene-association score: diabetes mellitus, insulin-dependent, 18 (10), haemophilus meningitis (10), diabetes mellitus, insulin-dependent, 17 (9), punctate epithelial keratoconjunctivitis (9), autoimmune disease of gastrointestinal tract (8), juvenile dermatitis herpetiformis (8), heart block, congenital (8), superficial keratitis (7), adrenal cortical hypofunction (7), herpes gestationis (7), autoimmune disease of endocrine system (7), jejunal adenocarcinoma (7), childhood type dermatomyositis (6), diffuse scleroderma (6), adie pupil (6), diabetes mellitus, insulin-dependent, 2 (6), autoimmune disease of skin and connective tissue (6), diabetes mellitus, insulin-dependent, 11 (6), immunoglobulin alpha deficiency (6), diabetes mellitus, insulin-dependent, 5 (5), hypersensitivity reaction disease (5), malignant essential hypertension (5), ascending cholangitis (5), toxic diffuse goiter (4), neuromuscular junction disease (4), diabetes mellitus, insulin-dependent (2), immune system disease (1), cholangitis, primary sclerosing (1), glucose metabolism disease (1)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D004054 Diethylstilbestrol D013749 Tetrachlorodibenzodioxin C006632 arsenic trioxide D001151 Arsenic D001241 Aspirin D002104 Cadmium D002211 Capsaicin D002737 Chloroprene D002794 Choline D003042 Cocaine more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 158.76 RPKM in Brain - Cerebellum Total median expression: 746.01 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-25.20	66	-0.382	Picture	PostScript	Text
3' UTR	-251.70	648	-0.388	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR000488 - Death
IPR011029 - DEATH-like
IPR001368 - TNFR/NGFR_Cys_rich_reg
IPR022329 - TNFR_25

Pfam Domains:
PF00020 - TNFR/NGFR cysteine-rich region
PF00531 - Death domain

SCOP Domains:
47986 - DEATH domain
57586 - TNF receptor-like
57184 - Growth factor receptor domain

ModBase Predicted Comparative 3D Structure on Q93038


Front	Top	Side

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Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0005031 tumor necrosis factor-activated receptor activity GO:0038023 signaling receptor activity Biological Process: GO:0006915 apoptotic process GO:0006954 inflammatory response GO:0006955 immune response GO:0007165 signal transduction GO:0007166 cell surface receptor signaling pathway GO:0007275 multicellular organism development GO:0032496 response to lipopolysaccharide GO:0033209 tumor necrosis factor-mediated signaling pathway GO:0042127 regulation of cell proliferation GO:0042981 regulation of apoptotic process GO:0097190 apoptotic signaling pathway Cellular Component: GO:0005576 extracellular region GO:0005829 cytosol GO:0005886 plasma membrane GO:0005887 integral component of plasma membrane GO:0016020 membrane GO:0016021 integral component of membrane

Descriptions from all associated GenBank mRNAs


	AB018263 - Homo sapiens KIAA0720 mRNA for KIAA0720 protein. AK226112 - Homo sapiens mRNA for ATP-binding cassette, sub-family A, member 2 isoform a variant, clone: hg01099. U75380 - Human apoptosis-mediating receptor TRAMP mRNA, partial cds. AY358309 - Homo sapiens clone DNA58801 DR3 (UNQ455) mRNA, complete cds. U83597 - Human death domain receptor 3 (DDR3) mRNA, partial cds. AK094488 - Homo sapiens cDNA FLJ37169 fis, clone BRACE2027770, highly similar to WSL-1 PROTEIN PRECURSOR. AK094463 - Homo sapiens cDNA FLJ37144 fis, clone BRACE2024610, highly similar to Tumor necrosis factor receptor superfamily member 25 precursor. U74611 - Human Apo-3 mRNA, complete cds. AF026070 - Homo sapiens death receptor 3 beta (DR3) mRNA, complete cds. AF026071 - Homo sapiens soluble death receptor 3 beta (DR3) mRNA, complete cds. Y09392 - H.sapiens mRNA for WSL-LR, WSL-S1 and WSL-S2 proteins. BC117189 - Homo sapiens tumor necrosis factor receptor superfamily, member 25, mRNA (cDNA clone MGC:150798 IMAGE:40125740), complete cds. BC143886 - Homo sapiens tumor necrosis factor receptor superfamily, member 25, mRNA (cDNA clone MGC:177419 IMAGE:9052402), complete cds. JD151786 - Sequence 132810 from Patent EP1572962. JD121753 - Sequence 102777 from Patent EP1572962. JD458929 - Sequence 439953 from Patent EP1572962. JD327061 - Sequence 308085 from Patent EP1572962. U72763 - Human death receptor 3 (DR3) mRNA, complete cds. U78029 - Human aoptosis inducing receptor AIR mRNA, complete cds. U94501 - Human lymphocyte associated receptor of death 1a mRNA, complete cds. U94502 - Human lymphocyte associated receptor of death 1b mRNA, alternatively spliced, complete cds. U94503 - Human lymphocyte associated receptor of death 2 mRNA, alternatively spliced, complete cds. U94504 - Human lymphocyte associated receptor of death 3 mRNA, alternatively spliced, complete cds. U94505 - Human lymphocyte associated receptor of death 4 mRNA, alternatively spliced, complete cds. U94506 - Human lymphocyte associated receptor of death 5 mRNA, alternatively spliced, complete cds. U94507 - Human lymphocyte associated receptor of death 6 mRNA, alternatively spliced, complete cds. U94508 - Human lymphocyte associated receptor of death 7 mRNA, alternatively spliced, complete cds. U94509 - Human lymphocyte associated receptor of death 8 mRNA, alternatively spliced, complete cds. U94510 - Human lymphocyte associated receptor of death 9 mRNA, alternatively spliced, complete cds. JD175084 - Sequence 156108 from Patent EP1572962. HQ258574 - Synthetic construct Homo sapiens clone IMAGE:100073099 tumor necrosis factor receptor superfamily, member 25 (TNFRSF25), transcript variant 2 (TNFRSF25) gene, encodes complete protein. AB590587 - Synthetic construct DNA, clone: pFN21AE1895, Homo sapiens TNFRSF25 gene for tumor necrosis factor receptor superfamily, member 25, without stop codon, in Flexi system. JD443569 - Sequence 424593 from Patent EP1572962. JD479840 - Sequence 460864 from Patent EP1572962. JD058270 - Sequence 39294 from Patent EP1572962. JD258696 - Sequence 239720 from Patent EP1572962. JD456560 - Sequence 437584 from Patent EP1572962. JD106346 - Sequence 87370 from Patent EP1572962. AB308321 - Homo sapiens TNFRSF25 mRNA for tumor necrosis factor receptor superfamily member 25 deletion mutant, complete cds. U83598 - Human death domain receptor 3 soluble form (DDR3) mRNA, partial cds. U75381 - Human apoptosis-mediating receptor TRAMP ex mRNA, alternatively spliced, partial cds. U94512 - Human lymphocyte associated receptor of death 11 mRNA, alternatively spliced, partial cds. U83600 - Human death domain receptor 3 (DDR3) mRNA, alternatively spliced form 2, partial cds. U94511 - Human lymphocyte associated receptor of death 10 pseudogene, partial sequence. AK131074 - Homo sapiens mRNA for FLJ00260 protein.

Biochemical and Signaling Pathways


	BioCarta from NCI Cancer Genome Anatomy Project h_deathPathway - Induction of apoptosis through DR3 and DR4/5 Death Receptors Reactome (by CSHL, EBI, and GO) Protein Q93038 (Reactome details) participates in the following event(s): R-HSA-5693012 TNFSF15 binds TNFRSF25 R-HSA-5669034 TNFs bind their physiological receptors R-HSA-5668541 TNFR2 non-canonical NF-kB pathway R-HSA-1280215 Cytokine Signaling in Immune system R-HSA-168256 Immune System

Other Names for This Gene


	Alternate Gene Symbols: APO3, B1ALX2, B1ALX3, B7ZLL7, DDR3, DR3, ENST00000356876.1, ENST00000356876.2, ENST00000356876.3, ENST00000356876.4, ENST00000356876.5, ENST00000356876.6, ENST00000356876.7, NM_003790, O00275, O00276, O00277, O00278, O00279, O00280, O14865, O14866, P78507, P78515, Q17RU4, Q92983, Q93036, Q93037, Q93038, Q99722, Q99830, Q99831, Q9BY86, Q9UME0, Q9UME1, Q9UME5, TNFRSF12, TNR25_HUMAN, uc317zts.1, uc317zts.2, UNQ455/PRO779, WSL, WSL1 UCSC ID: ENST00000356876.8_10 RefSeq Accession: NM_003790.3 Protein: Q93038 (aka TNR25_HUMAN or TR25_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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