Human Gene TMSB10 (ENST00000233143.6_4) from GENCODE V47lift37

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Description: thymosin beta 10 (from RefSeq NM_021103.4)
Gencode Transcript: ENST00000233143.6_4
Gencode Gene: ENSG00000034510.6_7
Transcript (Including UTRs)
Position: hg19 chr2:85,132,780-85,133,795 Size: 1,016 Total Exon Count: 3 Strand: +
Coding Region
Position: hg19 chr2:85,133,142-85,133,547 Size: 406 Coding Exon Count: 2

Page Index	Sequence and Links	UniProtKB Comments	Primers	MalaCards	CTD
Gene Alleles	RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species
GO Annotations	mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr2:85,132,780-85,133,795)			mRNA (may differ from genome)		Protein (44 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Malacards	MGI	OMIM	PubMed	UniProtKB
Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: TYB10_HUMAN DESCRIPTION: RecName: Full=Thymosin beta-10; FUNCTION: Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity). SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. DEVELOPMENTAL STAGE: Found to decrease dramatically after birth. SIMILARITY: Belongs to the thymosin beta family. SEQUENCE CAUTION: Sequence=AAA36746.1; Type=Erroneous initiation; Sequence=AAC41691.1; Type=Erroneous initiation;

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: TMSB10 Diseases sorted by gene-association score: primary bacterial infectious disease (1)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D016604 Aflatoxin B1 D013749 Tetrachlorodibenzodioxin D001564 Benzo(a)pyrene D004041 Dietary Fats D004997 Ethinyl Estradiol D014635 Valproic Acid D014640 Vancomycin C006253 pirinixic acid C049325 1,2-dithiol-3-thione C019499 2-nitrofluorene more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 1818.88 RPKM in Cells - Cultured fibroblasts Total median expression: 28107.50 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-17.20	78	-0.221	Picture	PostScript	Text
3' UTR	-70.80	248	-0.285	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR001152 - Thymosin_b4
IPR016323 - Thymosin_b4_chordata

Pfam Domains:
PF01290 - Thymosin beta-4 family
PF02205 - WH2 motif

ModBase Predicted Comparative 3D Structure on P63313


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0003779 actin binding GO:0003785 actin monomer binding GO:0005515 protein binding Biological Process: GO:0007015 actin filament organization Cellular Component: GO:0005737 cytoplasm GO:0005856 cytoskeleton

Descriptions from all associated GenBank mRNAs


	AK130949 - Homo sapiens cDNA FLJ27439 fis, clone ADG99901, highly similar to Homo sapiens thymosin, beta 10 (TMSB10). D28363 - Homo sapiens mRNA for thymosin beta-10, 5'UTR region. AK311952 - Homo sapiens cDNA, FLJ92220, Homo sapiens thymosin, beta 10 (TMSB10), mRNA. BC016731 - Homo sapiens thymosin beta 10, mRNA (cDNA clone MGC:24497 IMAGE:4095378), complete cds. BC107889 - Homo sapiens cDNA clone IMAGE:6651898. S54005 - thymosin beta-10 [human, metastatic melanoma cell line, mRNA, 453 nt]. BC016025 - Homo sapiens thymosin beta 10, mRNA (cDNA clone MGC:10193 IMAGE:3909431), complete cds. M20259 - Human thymosin beta-10 mRNA, complete cds. AY453400 - Homo sapiens migration-inducing protein 12 (MIG12) mRNA, complete cds. M92381 - Human thymosin beta 10 mRNA, complete cds. EU831701 - Synthetic construct Homo sapiens clone HAIB:100066730; DKFZo003C1120 thymosin beta 10 protein (TMSB10) gene, encodes complete protein. EU832349 - Synthetic construct Homo sapiens clone HAIB:100067378; DKFZo008H0327 thymosin beta 10 protein (TMSB10) gene, encodes complete protein. EU831614 - Synthetic construct Homo sapiens clone HAIB:100066643; DKFZo007C1119 thymosin beta 10 protein (TMSB10) gene, encodes complete protein. KJ892702 - Synthetic construct Homo sapiens clone ccsbBroadEn_02096 TMSB10 gene, encodes complete protein. KJ897976 - Synthetic construct Homo sapiens clone ccsbBroadEn_07370 TMSB10 gene, encodes complete protein. EU832434 - Synthetic construct Homo sapiens clone HAIB:100067463; DKFZo004H0328 thymosin beta 10 protein (TMSB10) gene, encodes complete protein. JD114643 - Sequence 95667 from Patent EP1572962. JD116130 - Sequence 97154 from Patent EP1572962. JD114416 - Sequence 95440 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: ENST00000233143.1, ENST00000233143.2, ENST00000233143.3, ENST00000233143.4, ENST00000233143.5, NM_021103, P13472, P63313, PTMB10, Q596K9, THYB10, TYB10_HUMAN, uc317dwo.1, uc317dwo.2 UCSC ID: ENST00000233143.6_4 RefSeq Accession: NM_021103.4 Protein: P63313 (aka TYB10_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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