ID:TMPSD_HUMAN DESCRIPTION: RecName: Full=Transmembrane protease serine 13; EC=3.4.21.-; AltName: Full=Membrane-type mosaic serine protease; Short=Mosaic serine protease; SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein (Potential). TISSUE SPECIFICITY: Isoform 1 and isoform 3 are predominantly expressed in lung, placenta, pancreas, and prostate. Isoform 3 is weakly expressed in testis and peripheral blood lymphocytes. POLYMORPHISM: The repeat A-S-P-A-[GLQR] is polymorphic and the number of copies varies between 12 to 14. SIMILARITY: Belongs to the peptidase S1 family. SIMILARITY: Contains 1 LDL-receptor class A domain. SIMILARITY: Contains 1 peptidase S1 domain. SIMILARITY: Contains 1 SRCR domain. CAUTION: Was termed TMPRSS6 (Ref.3).
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9BYE2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
