Human Gene PACC1 (ENST00000261455.9_8) from GENCODE V47lift37
  Description: proton activated chloride channel 1, transcript variant 6 (from RefSeq NR_165303.1)
Gencode Transcript: ENST00000261455.9_8
Gencode Gene: ENSG00000065600.13_10
Transcript (Including UTRs)
   Position: hg19 chr1:212,537,270-212,588,228 Size: 50,959 Total Exon Count: 8 Strand: -
Coding Region
   Position: hg19 chr1:212,538,557-212,588,099 Size: 49,543 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsPrimersGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:212,537,270-212,588,228)mRNA (may differ from genome)Protein (350 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsMGI
OMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: TM206_HUMAN
DESCRIPTION: RecName: Full=Transmembrane protein 206;
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential).
SIMILARITY: Belongs to the TMEM206 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 28.65 RPKM in Brain - Spinal cord (cervical c-1)
Total median expression: 160.22 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -68.60129-0.532 Picture PostScript Text
3' UTR -320.901287-0.249 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  Pfam Domains:
PF15122 - TMEM206 protein family

ModBase Predicted Comparative 3D Structure on Q9H813
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AK001736 - Homo sapiens cDNA FLJ10874 fis, clone NT2RP4001803.
JD181644 - Sequence 162668 from Patent EP1572962.
JD057068 - Sequence 38092 from Patent EP1572962.
JD262627 - Sequence 243651 from Patent EP1572962.
JD516728 - Sequence 497752 from Patent EP1572962.
JD172483 - Sequence 153507 from Patent EP1572962.
BC006320 - Homo sapiens transmembrane protein 206, mRNA (cDNA clone MGC:12591 IMAGE:4137890), complete cds.
AK024066 - Homo sapiens cDNA FLJ14004 fis, clone Y79AA1002351.
AK297200 - Homo sapiens cDNA FLJ55748 complete cds.
JD039756 - Sequence 20780 from Patent EP1572962.
AK295224 - Homo sapiens cDNA FLJ57110 complete cds.
JD260859 - Sequence 241883 from Patent EP1572962.
JD353531 - Sequence 334555 from Patent EP1572962.
JD167528 - Sequence 148552 from Patent EP1572962.
JD146317 - Sequence 127341 from Patent EP1572962.
DQ599381 - Homo sapiens piRNA piR-37447, complete sequence.
JD309083 - Sequence 290107 from Patent EP1572962.
JD565982 - Sequence 547006 from Patent EP1572962.
JD435766 - Sequence 416790 from Patent EP1572962.
JD197427 - Sequence 178451 from Patent EP1572962.
JD470858 - Sequence 451882 from Patent EP1572962.
HQ448200 - Synthetic construct Homo sapiens clone IMAGE:100071597; CCSB004950_01 chromosome 1 open reading frame 75 (TMEM206) gene, encodes complete protein.
KJ894167 - Synthetic construct Homo sapiens clone ccsbBroadEn_03561 TMEM206 gene, encodes complete protein.
CR457268 - Homo sapiens full open reading frame cDNA clone RZPDo834A0313D for gene FLJ10874, hypothetical protein FLJ10874; complete cds, incl. stopcodon.
CU675347 - Synthetic construct Homo sapiens gateway clone IMAGE:100023357 5' read C1orf75 mRNA.

-  Other Names for This Gene
  Alternate Gene Symbols: B7Z4D6, C1orf75 , ENST00000261455.1, ENST00000261455.2, ENST00000261455.3, ENST00000261455.4, ENST00000261455.5, ENST00000261455.6, ENST00000261455.7, ENST00000261455.8, NR_165303, PACC1 , PACC1_HUMAN, Q6IA87, Q9H813, Q9NV85, TMEM206 , uc317gqd.1, uc317gqd.2
UCSC ID: ENST00000261455.9_8
RefSeq Accession: NM_018252.3
Protein: Q9H813 (aka TM206_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.