Human Gene STIMATE (ENST00000355083.11_7) from GENCODE V47lift37
  Description: STIM activating enhancer (from RefSeq NM_198563.5)
Gencode Transcript: ENST00000355083.11_7
Gencode Gene: ENSG00000213533.13_13
Transcript (Including UTRs)
   Position: hg19 chr3:52,870,749-52,931,564 Size: 60,816 Total Exon Count: 8 Strand: -
Coding Region
   Position: hg19 chr3:52,874,510-52,931,466 Size: 56,957 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsPrimersGene AllelesRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:52,870,749-52,931,564)mRNA (may differ from genome)Protein (294 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsMGI
OMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: TM110_HUMAN
DESCRIPTION: RecName: Full=Transmembrane protein 110;
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential).

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 3.86 RPKM in Liver
Total median expression: 84.26 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -56.3098-0.574 Picture PostScript Text
3' UTR -1413.203761-0.376 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR022127 - DUF3661_TM

Pfam Domains:
PF12400 - STIMATE family

ModBase Predicted Comparative 3D Structure on Q86TL2
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologGenome Browser
Gene DetailsGene Details   Gene Details
Gene SorterGene Sorter   Gene Sorter
 RGD   SGD
     Protein Sequence
     Alignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005246 calcium channel regulator activity
GO:0005515 protein binding

Biological Process:
GO:0032237 activation of store-operated calcium channel activity
GO:0035584 calcium-mediated signaling using intracellular calcium source
GO:0070886 positive regulation of calcineurin-NFAT signaling cascade

Cellular Component:
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0032541 cortical endoplasmic reticulum


-  Descriptions from all associated GenBank mRNAs
  AL833659 - Homo sapiens mRNA; cDNA DKFZp667E1121 (from clone DKFZp667E1121).
BC108689 - Homo sapiens cDNA clone IMAGE:4347363, **** WARNING: chimeric clone ****.
AK094932 - Homo sapiens cDNA FLJ37613 fis, clone BRCOC2011544.
BX648562 - Homo sapiens mRNA; cDNA DKFZp779M0254 (from clone DKFZp779M0254).
AK124386 - Homo sapiens cDNA FLJ42395 fis, clone ASTRO2001076.
DQ582230 - Homo sapiens piRNA piR-32342, complete sequence.
BC047015 - Homo sapiens transmembrane protein 110, mRNA (cDNA clone MGC:52022 IMAGE:5199769), complete cds.
AY726591 - Homo sapiens clone MO-18 mRNA sequence.
BC022209 - Homo sapiens transmembrane protein 110, mRNA (cDNA clone IMAGE:4577480).
JD436374 - Sequence 417398 from Patent EP1572962.
JD254485 - Sequence 235509 from Patent EP1572962.
JD119548 - Sequence 100572 from Patent EP1572962.
KJ896153 - Synthetic construct Homo sapiens clone ccsbBroadEn_05547 TMEM110 gene, encodes complete protein.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000355083.1, ENST00000355083.10, ENST00000355083.2, ENST00000355083.3, ENST00000355083.4, ENST00000355083.5, ENST00000355083.6, ENST00000355083.7, ENST00000355083.8, ENST00000355083.9, NM_198563, Q86TL2, STIMATE , STIMA_HUMAN, TMEM110 , uc317yxv.1, uc317yxv.2
UCSC ID: ENST00000355083.11_7
RefSeq Accession: NM_198563.5
Protein: Q86TL2 (aka TM110_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.