ID:TMED9_HUMAN DESCRIPTION: RecName: Full=Transmembrane emp24 domain-containing protein 9; AltName: Full=GMP25; AltName: Full=Glycoprotein 25L2; AltName: Full=p24 family protein alpha-2; Short=p24alpha2; AltName: Full=p25; Flags: Precursor; FUNCTION: Appears to be involved in vesicular protein trafficking, mainly in the early secretory pathway. In COPI vesicle-mediated retrograde transport involved in the coatomer recruitment to membranes of the early secretory pathway. Increases coatomer- dependent activity of ARFGAP2. Thought to play a crucial role in the specific retention of p24 complexes in cis-Golgi membranes; specifically contributes to the coupled localization of TMED2 and TMED10 in the cis-Golgi network. May be involved in organization of intracellular membranes, such as of the ER-Golgi intermediate compartment and the Golgi apparatus. Involved in ER localization of PTPN2 isoform PTPB. SUBUNIT: Monomer and homodimer in endoplasmic reticulum. Predominantly monomeric and to lesser extent homodimeric in endoplasmic reticulum-Golgi intermediate compartment and cis-Golgi network. Probably oligomerizes with other members of the EMP24/GP25L family such as TMED2, TMED7 and TMED10. Interacts with TMED5. Interacts (via C-terminus) with COPG1; the interaction involves dimeric TMED9. Interacts with PTPN2 and SPAST. INTERACTION: P17706-1:PTPN2; NbExp=5; IntAct=EBI-1056827, EBI-4409481; SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Golgi apparatus, cis-Golgi network membrane; Single-pass type I membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Single-pass type I membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein (By similarity). Note=Cycles between compartments of the early secretatory pathway. PTM: N-linked glycosylated containing high mannose. SIMILARITY: Belongs to the EMP24/GP25L family. SIMILARITY: Contains 1 GOLD domain. SEQUENCE CAUTION: Sequence=AAL35268.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAA62380.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9BVK6
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006888 ER to Golgi vesicle-mediated transport GO:0006890 retrograde vesicle-mediated transport, Golgi to ER GO:0007030 Golgi organization GO:0010638 positive regulation of organelle organization GO:0015031 protein transport GO:0048205 COPI coating of Golgi vesicle GO:0032527 protein exit from endoplasmic reticulum GO:0034498 early endosome to Golgi transport
AK313292 - Homo sapiens cDNA, FLJ93804, highly similar to Homo sapiens gp25L2 protein (HSGP25L2G), mRNA. JD309139 - Sequence 290163 from Patent EP1572962. BC001123 - Homo sapiens transmembrane emp24 protein transport domain containing 9, mRNA (cDNA clone MGC:2142 IMAGE:2967520), complete cds. LF384921 - JP 2014500723-A/192424: Polycomb-Associated Non-Coding RNAs. JD449879 - Sequence 430903 from Patent EP1572962. KJ894056 - Synthetic construct Homo sapiens clone ccsbBroadEn_03450 TMED9 gene, encodes complete protein. X90872 - H.sapiens mRNA for gp25L2 protein. AF441399 - Homo sapiens p25 mRNA, complete cds. AK298435 - Homo sapiens cDNA FLJ56646 complete cds, highly similar to Transmembrane emp24 domain-containing protein 9 precursor. LF331775 - JP 2014500723-A/139278: Polycomb-Associated Non-Coding RNAs. LF331776 - JP 2014500723-A/139279: Polycomb-Associated Non-Coding RNAs. LF331777 - JP 2014500723-A/139280: Polycomb-Associated Non-Coding RNAs. LF331779 - JP 2014500723-A/139282: Polycomb-Associated Non-Coding RNAs. LF331780 - JP 2014500723-A/139283: Polycomb-Associated Non-Coding RNAs. JD122193 - Sequence 103217 from Patent EP1572962. LF331781 - JP 2014500723-A/139284: Polycomb-Associated Non-Coding RNAs. JD466585 - Sequence 447609 from Patent EP1572962. JD539216 - Sequence 520240 from Patent EP1572962. JD471294 - Sequence 452318 from Patent EP1572962. JD240210 - Sequence 221234 from Patent EP1572962. JD074512 - Sequence 55536 from Patent EP1572962. JD044737 - Sequence 25761 from Patent EP1572962. JD483331 - Sequence 464355 from Patent EP1572962. LF331782 - JP 2014500723-A/139285: Polycomb-Associated Non-Coding RNAs. JD559109 - Sequence 540133 from Patent EP1572962. JD221256 - Sequence 202280 from Patent EP1572962. JD189450 - Sequence 170474 from Patent EP1572962. JD160054 - Sequence 141078 from Patent EP1572962. JD413911 - Sequence 394935 from Patent EP1572962. LF331783 - JP 2014500723-A/139286: Polycomb-Associated Non-Coding RNAs. JD267007 - Sequence 248031 from Patent EP1572962. JD348502 - Sequence 329526 from Patent EP1572962. JD501268 - Sequence 482292 from Patent EP1572962. JD533607 - Sequence 514631 from Patent EP1572962. JD446175 - Sequence 427199 from Patent EP1572962. JD078092 - Sequence 59116 from Patent EP1572962. JD220648 - Sequence 201672 from Patent EP1572962. JD077746 - Sequence 58770 from Patent EP1572962. JD282802 - Sequence 263826 from Patent EP1572962. JD470344 - Sequence 451368 from Patent EP1572962. AY523817 - Homo sapiens sulfotransferase SULT1C-like mRNA, partial sequence. JD184369 - Sequence 165393 from Patent EP1572962. JD074512 - Sequence 55536 from Patent EP1572962. JD044737 - Sequence 25761 from Patent EP1572962. MA620498 - JP 2018138019-A/192424: Polycomb-Associated Non-Coding RNAs. MA567352 - JP 2018138019-A/139278: Polycomb-Associated Non-Coding RNAs. MA567353 - JP 2018138019-A/139279: Polycomb-Associated Non-Coding RNAs. MA567354 - JP 2018138019-A/139280: Polycomb-Associated Non-Coding RNAs. MA567356 - JP 2018138019-A/139282: Polycomb-Associated Non-Coding RNAs. MA567357 - JP 2018138019-A/139283: Polycomb-Associated Non-Coding RNAs. MA567358 - JP 2018138019-A/139284: Polycomb-Associated Non-Coding RNAs. MA567359 - JP 2018138019-A/139285: Polycomb-Associated Non-Coding RNAs. MA567360 - JP 2018138019-A/139286: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q9BVK6 (Reactome details) participates in the following event(s):
R-HSA-6807875 ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex R-HSA-6811417 ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi R-HSA-6807877 ARFGAPs stimulate ARF GTPase activity R-HSA-6811418 ARFGAPs stimulate ARF GTPase activity at the Golgi membrane R-HSA-6809003 ERGIC-to-Golgi vesicles bind dynein:dynactin R-HSA-6811426 Retrograde COPI vesicles bind kinesin and microtubules R-HSA-6811423 Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs R-HSA-6809011 cis-Golgi t-SNAREs bind YKT6 on tethered vesicle R-HSA-6809006 Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex R-HSA-6807878 COPI-mediated anterograde transport R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic R-HSA-199977 ER to Golgi Anterograde Transport R-HSA-8856688 Golgi-to-ER retrograde transport R-HSA-199991 Membrane Trafficking R-HSA-948021 Transport to the Golgi and subsequent modification R-HSA-6811442 Intra-Golgi and retrograde Golgi-to-ER traffic R-HSA-5653656 Vesicle-mediated transport R-HSA-446203 Asparagine N-linked glycosylation R-HSA-597592 Post-translational protein modification R-HSA-392499 Metabolism of proteins
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
