Human Gene TMED2 (ENST00000262225.8_4) from GENCODE V47lift37
  Description: transmembrane p24 trafficking protein 2, transcript variant 1 (from RefSeq NM_006815.4)
Gencode Transcript: ENST00000262225.8_4
Gencode Gene: ENSG00000086598.11_7
Transcript (Including UTRs)
   Position: hg19 chr12:124,069,099-124,083,129 Size: 14,031 Total Exon Count: 4 Strand: +
Coding Region
   Position: hg19 chr12:124,069,184-124,081,276 Size: 12,093 Coding Exon Count: 4 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:124,069,099-124,083,129)mRNA (may differ from genome)Protein (201 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MalacardsMGIPubMedUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: Q6FHT8_HUMAN
DESCRIPTION: SubName: Full=RNP24 protein; SubName: Full=Transmembrane emp24 domain trafficking protein 2, isoform CRA_a; SubName: Full=cDNA, FLJ93436, Homo sapiens coated vesicle membrane protein (RNP24), mRNA;
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (By similarity).
SIMILARITY: Belongs to the EMP24/GP25L family.
SIMILARITY: Contains 1 GOLD domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: TMED2
Diseases sorted by gene-association score: charcot-marie-tooth disease, axonal, type 2l (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 68.04 RPKM in Cells - Cultured fibroblasts
Total median expression: 1769.28 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -45.9085-0.540 Picture PostScript Text
3' UTR -446.201853-0.241 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR009038 - GOLD

Pfam Domains:
PF01105 - emp24/gp25L/p24 family/GOLD

SCOP Domains:
101576 - Supernatant protein factor (SPF), C-terminal domain

ModBase Predicted Comparative 3D Structure on Q6FHT8
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologGenome BrowserGenome Browser
Gene DetailsGene Details Gene DetailsGene DetailsGene Details
Gene SorterGene Sorter Gene SorterGene SorterGene Sorter
 RGDEnsembl WormBaseSGD
    Protein SequenceProtein Sequence
    AlignmentAlignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Biological Process:
GO:0001701 in utero embryonic development
GO:0001756 somitogenesis
GO:0001843 neural tube closure
GO:0001892 embryonic placenta development
GO:0001893 maternal placenta development
GO:0001947 heart looping
GO:0010628 positive regulation of gene expression
GO:0032525 somite rostral/caudal axis specification
GO:0035264 multicellular organism growth
GO:0036342 post-anal tail morphogenesis
GO:0048598 embryonic morphogenesis
GO:0060716 labyrinthine layer blood vessel development

Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030137 COPI-coated vesicle
GO:0042589 zymogen granule membrane
GO:0043231 intracellular membrane-bounded organelle


-  Descriptions from all associated GenBank mRNAs
  AK298167 - Homo sapiens cDNA FLJ52153 complete cds, highly similar to Transmembrane emp24 domain-containing protein 2 precursor.
AK312975 - Homo sapiens cDNA, FLJ93436, Homo sapiens coated vesicle membrane protein (RNP24), mRNA.
AK303189 - Homo sapiens cDNA FLJ52154 complete cds, moderately similar to Transmembrane emp24 domain-containing protein 2 precursor.
JD022807 - Sequence 3831 from Patent EP1572962.
JC506674 - Sequence 42 from Patent EP2733220.
JC737786 - Sequence 42 from Patent WO2014075939.
JC506661 - Sequence 29 from Patent EP2733220.
JC737773 - Sequence 29 from Patent WO2014075939.
JC506688 - Sequence 56 from Patent EP2733220.
JC737800 - Sequence 56 from Patent WO2014075939.
JC506666 - Sequence 34 from Patent EP2733220.
JC737778 - Sequence 34 from Patent WO2014075939.
X92098 - H.sapiens mRNA for transmembrane protein rnp24.
BC025957 - Homo sapiens transmembrane emp24 domain trafficking protein 2, mRNA (cDNA clone MGC:39201 IMAGE:5020405), complete cds.
JD029391 - Sequence 10415 from Patent EP1572962.
CU693080 - Synthetic construct Homo sapiens gateway clone IMAGE:100021835 5' read TMED2 mRNA.
KJ898321 - Synthetic construct Homo sapiens clone ccsbBroadEn_07715 TMED2 gene, encodes complete protein.
CR541682 - Homo sapiens full open reading frame cDNA clone RZPDo834C0628D for gene RNP24, coated vesicle membrane protein; complete cds, without stopcodon.
CR541663 - Homo sapiens full open reading frame cDNA clone RZPDo834G0227D for gene RNP24, coated vesicle membrane protein; complete cds, incl. stopcodon.
AK024976 - Homo sapiens cDNA: FLJ21323 fis, clone COL02374.
JD160229 - Sequence 141253 from Patent EP1572962.
JD156671 - Sequence 137695 from Patent EP1572962.
JD089646 - Sequence 70670 from Patent EP1572962.
JD046536 - Sequence 27560 from Patent EP1572962.
JD473648 - Sequence 454672 from Patent EP1572962.
JD301399 - Sequence 282423 from Patent EP1572962.
JD432670 - Sequence 413694 from Patent EP1572962.
JD551347 - Sequence 532371 from Patent EP1572962.
JD137340 - Sequence 118364 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000262225.1, ENST00000262225.2, ENST00000262225.3, ENST00000262225.4, ENST00000262225.5, ENST00000262225.6, ENST00000262225.7, hCG_1743563 , NM_006815, Q6FHT8, Q6FHT8_HUMAN, RNP24 , TMED2 , uc317gyc.1, uc317gyc.2
UCSC ID: ENST00000262225.8_4
RefSeq Accession: NM_006815.4
Protein: Q6FHT8

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.