ID:TLR8_HUMAN DESCRIPTION: RecName: Full=Toll-like receptor 8; AltName: CD_antigen=CD288; Flags: Precursor; FUNCTION: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. SUBUNIT: Interacts with MYD88 via their respective TIR domains. Interacts with UNC93B1 (By similarity). Interacts with BTK. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (By similarity). TISSUE SPECIFICITY: Detected in brain, heart, lung, liver, placenta, in monocytes, and at lower levels in CD11c+ immature dendritic cells. SIMILARITY: Belongs to the Toll-like receptor family. SIMILARITY: Contains 23 LRR (leucine-rich) repeats. SIMILARITY: Contains 1 LRRCT domain. SIMILARITY: Contains 1 TIR domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00560 - Leucine Rich Repeat PF01582 - TIR domain PF13306 - BspA type Leucine rich repeat region (6 copies) PF13676 - TIR domain PF13855 - Leucine rich repeat
SCOP Domains: 52047 - RNI-like 52058 - L domain-like 52075 - Outer arm dynein light chain 1 52200 - Toll/Interleukin receptor TIR domain
ModBase Predicted Comparative 3D Structure on Q9NR97
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK314240 - Homo sapiens cDNA, FLJ94985. AF246971 - Homo sapiens Toll-like receptor 8 (TLR8) mRNA, complete cds. LP895634 - Sequence 498 from Patent EP3253886. JD110360 - Sequence 91384 from Patent EP1572962. AY358296 - Homo sapiens clone DNA42663 TLR8 (UNQ249) mRNA, complete cds. BC101074 - Homo sapiens toll-like receptor 8, mRNA (cDNA clone MGC:119598 IMAGE:40008787), complete cds. BC101075 - Homo sapiens toll-like receptor 8, mRNA (cDNA clone MGC:119599 IMAGE:40008788), complete cds. BC101076 - Homo sapiens toll-like receptor 8, mRNA (cDNA clone MGC:119600 IMAGE:40008792), complete cds. BC101077 - Homo sapiens toll-like receptor 8, mRNA (cDNA clone MGC:119601 IMAGE:40008793), complete cds. AF245703 - Homo sapiens toll-like receptor 8 (TLR8) mRNA, complete cds. JD171756 - Sequence 152780 from Patent EP1572962. JD171757 - Sequence 152781 from Patent EP1572962. KJ898881 - Synthetic construct Homo sapiens clone ccsbBroadEn_08275 TLR8 gene, encodes complete protein. AB445666 - Homo sapiens TLR8 mRNA for toll-like receptor 8, complete cds. AK307562 - Homo sapiens cDNA, FLJ97510. AK297024 - Homo sapiens cDNA FLJ56817 complete cds, highly similar to Toll-like receptor 8 precursor. AK075117 - Homo sapiens cDNA FLJ90636 fis, clone PLACE1003737, highly similar to Toll-like receptor 8 precursor. JD022865 - Sequence 3889 from Patent EP1572962. JD035332 - Sequence 16356 from Patent EP1572962. JD028572 - Sequence 9596 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q9NR97 (Reactome details) participates in the following event(s):
R-HSA-1678923 TLR folding by chaperones GP96 and CNPY3 R-HSA-1678944 Folded full-length TLR7/8/9 dissociates from the GP96:CNPY3 complex R-HSA-167983 Ligand binds to TLR7 or TLR8 R-HSA-1678921 Full-length TLR3/7/8/9 binds to UNC93B1 R-HSA-975175 MyD88 interacts with the activated TLR receptor 7, 8 or 9 R-HSA-975156 IRAK4 binds to the activated TLR7/8 or 9 receptor:MyD88 complex R-HSA-975098 MyD88 oligomerization within the complex of activated TLR 7/8 or 9 : MyD88 R-HSA-975115 IRAK1/or IRAK2 binds to the activated IRAK4 :MyD88:activated TLR 7/8 or 9. R-HSA-975100 Dissociation of hp-IRAK1/or IRAK2:TRAF6-oligomer from the p-IRAK4 :oligo-Myd88:activated TLR7/8 or 9 complex R-HSA-975170 IRAK4 autophosphorylation in the complex with MyD88:activated TLR 7/8 or 9 R-HSA-975125 Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9 R-HSA-975134 Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9 R-HSA-975180 First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9 R-HSA-975160 Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:activated TLR 7/8 or 9 R-HSA-975111 TRAF6 binds to hp- IRAK1/or p-IRAK2:p-IRAK4:MyD88:activated TLR7/8 or 9 R-HSA-975188 TRAF6 interacts with IRF7 upon TLR7/8 or 9 activation R-HSA-975106 Phosphorylation and release of IRF7 upon TLR7/8 or 9 activation R-HSA-975118 TRAF6 ubiquitinqtes IRF7 in a K63-dependent manner following TLR7/8 or 9 stimulation R-HSA-1679131 Trafficking and processing of endosomal TLR R-HSA-168898 Toll-Like Receptors Cascades R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168249 Innate Immune System R-HSA-168256 Immune System R-HSA-975155 MyD88 dependent cascade initiated on endosome R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975110 TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
