ID:TLR7_HUMAN DESCRIPTION: RecName: Full=Toll-like receptor 7; Flags: Precursor; FUNCTION: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). SUBUNIT: Interacts with MYD88 via their respective TIR domains. Interacts with UNC93B1 (By similarity). SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass type I membrane protein (By similarity). Endosome (By similarity). Lysosome (By similarity). Cytoplasmic vesicle, phagosome. Note=Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist (By similarity). TISSUE SPECIFICITY: Detected in brain, placenta, spleen, stomach, small intestine, lung and in plasmacytoid pre-dendritic cells. SIMILARITY: Belongs to the Toll-like receptor family. SIMILARITY: Contains 27 LRR (leucine-rich) repeats. SIMILARITY: Contains 1 TIR domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF01582 - TIR domain PF12799 - Leucine Rich repeats (2 copies) PF13306 - BspA type Leucine rich repeat region (6 copies) PF13516 - Leucine Rich repeat PF13676 - TIR domain PF13855 - Leucine rich repeat
SCOP Domains: 52047 - RNI-like 52058 - L domain-like 52075 - Outer arm dynein light chain 1 52200 - Toll/Interleukin receptor TIR domain
ModBase Predicted Comparative 3D Structure on Q9NYK1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK313858 - Homo sapiens cDNA, FLJ94489, Homo sapiens toll-like receptor 7 (TLR7), mRNA. BC033651 - Homo sapiens toll-like receptor 7, mRNA (cDNA clone MGC:45096 IMAGE:5582912), complete cds. AF240467 - Homo sapiens toll-like receptor 7 (TLR7) mRNA, complete cds. AF245702 - Homo sapiens toll-like receptor 7 (TLR7) mRNA, complete cds. AY358292 - Homo sapiens clone DNA40021 TLR7 (UNQ248) mRNA, complete cds. JD250016 - Sequence 231040 from Patent EP1572962. JD378392 - Sequence 359416 from Patent EP1572962. JD040861 - Sequence 21885 from Patent EP1572962. CU689684 - Synthetic construct Homo sapiens gateway clone IMAGE:100020487 5' read TLR7 mRNA. DQ894457 - Synthetic construct Homo sapiens clone IMAGE:100008917; FLH170597.01L; RZPDo839H0397D toll-like receptor 7 (TLR7) gene, encodes complete protein. KJ898877 - Synthetic construct Homo sapiens clone ccsbBroadEn_08271 TLR7 gene, encodes complete protein. KR710902 - Synthetic construct Homo sapiens clone CCSBHm_00018089 TLR7 (TLR7) mRNA, encodes complete protein. AB445659 - Homo sapiens TLR7 mRNA for toll-like receptor 7, complete cds. DQ891269 - Synthetic construct clone IMAGE:100003899; FLH170601.01X; RZPDo839H0398D toll-like receptor 7 (TLR7) gene, encodes complete protein. JD515585 - Sequence 496609 from Patent EP1572962. JD208722 - Sequence 189746 from Patent EP1572962. JD430349 - Sequence 411373 from Patent EP1572962. JD529477 - Sequence 510501 from Patent EP1572962. JD169775 - Sequence 150799 from Patent EP1572962. JD306415 - Sequence 287439 from Patent EP1572962. JD055279 - Sequence 36303 from Patent EP1572962. JD125782 - Sequence 106806 from Patent EP1572962. JD325463 - Sequence 306487 from Patent EP1572962. JD152447 - Sequence 133471 from Patent EP1572962. JD408224 - Sequence 389248 from Patent EP1572962. JD408223 - Sequence 389247 from Patent EP1572962. JD393316 - Sequence 374340 from Patent EP1572962. JD277359 - Sequence 258383 from Patent EP1572962. JD401803 - Sequence 382827 from Patent EP1572962. JD481884 - Sequence 462908 from Patent EP1572962. JD481886 - Sequence 462910 from Patent EP1572962. JD481885 - Sequence 462909 from Patent EP1572962. JD446717 - Sequence 427741 from Patent EP1572962. JD102807 - Sequence 83831 from Patent EP1572962. JD062791 - Sequence 43815 from Patent EP1572962.
Biochemical and Signaling Pathways
BioCarta from NCI Cancer Genome Anatomy Project h_tollPathway - Toll-Like Receptor Pathway h_dcPathway - Dendritic cells in regulating TH1 and TH2 Development
Reactome (by CSHL, EBI, and GO)
Protein Q9NYK1 (Reactome details) participates in the following event(s):
R-HSA-1678920 TLR processing at low pH R-HSA-1678923 TLR folding by chaperones GP96 and CNPY3 R-HSA-1678944 Folded full-length TLR7/8/9 dissociates from the GP96:CNPY3 complex R-HSA-167983 Ligand binds to TLR7 or TLR8 R-HSA-1678921 Full-length TLR3/7/8/9 binds to UNC93B1 R-HSA-975175 MyD88 interacts with the activated TLR receptor 7, 8 or 9 R-HSA-975156 IRAK4 binds to the activated TLR7/8 or 9 receptor:MyD88 complex R-HSA-975098 MyD88 oligomerization within the complex of activated TLR 7/8 or 9 : MyD88 R-HSA-975115 IRAK1/or IRAK2 binds to the activated IRAK4 :MyD88:activated TLR 7/8 or 9. R-HSA-975100 Dissociation of hp-IRAK1/or IRAK2:TRAF6-oligomer from the p-IRAK4 :oligo-Myd88:activated TLR7/8 or 9 complex R-HSA-975170 IRAK4 autophosphorylation in the complex with MyD88:activated TLR 7/8 or 9 R-HSA-975125 Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9 R-HSA-975134 Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9 R-HSA-975180 First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9 R-HSA-975160 Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:activated TLR 7/8 or 9 R-HSA-975111 TRAF6 binds to hp- IRAK1/or p-IRAK2:p-IRAK4:MyD88:activated TLR7/8 or 9 R-HSA-975188 TRAF6 interacts with IRF7 upon TLR7/8 or 9 activation R-HSA-975106 Phosphorylation and release of IRF7 upon TLR7/8 or 9 activation R-HSA-975118 TRAF6 ubiquitinqtes IRF7 in a K63-dependent manner following TLR7/8 or 9 stimulation R-HSA-1679131 Trafficking and processing of endosomal TLR R-HSA-168898 Toll-Like Receptors Cascades R-HSA-168181 Toll Like Receptor 7/8 (TLR7/8) Cascade R-HSA-168249 Innate Immune System R-HSA-168256 Immune System R-HSA-975155 MyD88 dependent cascade initiated on endosome R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975110 TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
