ID:TLR6_HUMAN DESCRIPTION: RecName: Full=Toll-like receptor 6; AltName: CD_antigen=CD286; Flags: Precursor; FUNCTION: Participates in the innate immune response to Gram- positive bacteria and fungi. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR2. SUBUNIT: Binds TLR2 via their respective extracellular domains. Binds MYD88 via their respective TIR domains (By similarity). SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein (By similarity). Cytoplasmic vesicle, phagosome membrane; Single-pass type I membrane protein (By similarity). TISSUE SPECIFICITY: Detected in monocytes, CD11c+ immature dendritic cells, plasmacytoid pre-dendritic cells and dermal microvessel endothelial cells. SIMILARITY: Belongs to the Toll-like receptor family. SIMILARITY: Contains 12 LRR (leucine-rich) repeats. SIMILARITY: Contains 1 LRRCT domain. SIMILARITY: Contains 1 TIR domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
SCOP Domains: 52047 - RNI-like 52058 - L domain-like 52075 - Outer arm dynein light chain 1 52200 - Toll/Interleukin receptor TIR domain
ModBase Predicted Comparative 3D Structure on Q9Y2C9
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
JD179042 - Sequence 160066 from Patent EP1572962. JD421430 - Sequence 402454 from Patent EP1572962. JD179041 - Sequence 160065 from Patent EP1572962. JD199439 - Sequence 180463 from Patent EP1572962. JD325408 - Sequence 306432 from Patent EP1572962. JD350212 - Sequence 331236 from Patent EP1572962. JD168580 - Sequence 149604 from Patent EP1572962. JD208753 - Sequence 189777 from Patent EP1572962. AB020807 - Homo sapiens mRNA for TLR6, complete cds. JD082102 - Sequence 63126 from Patent EP1572962. JD147965 - Sequence 128989 from Patent EP1572962. JD104380 - Sequence 85404 from Patent EP1572962. BC111755 - Homo sapiens toll-like receptor 6, mRNA (cDNA clone MGC:133029 IMAGE:40007924), complete cds. AB445652 - Homo sapiens TLR6 mRNA for toll-like receptor 6, complete cds. AK313618 - Homo sapiens cDNA, FLJ94188, highly similar to Homo sapiens toll-like receptor 6 (TLR6), mRNA. KJ902091 - Synthetic construct Homo sapiens clone ccsbBroadEn_11485 TLR6 gene, encodes complete protein. KR711814 - Synthetic construct Homo sapiens clone CCSBHm_00031157 TLR6 (TLR6) mRNA, encodes complete protein. KR711815 - Synthetic construct Homo sapiens clone CCSBHm_00031159 TLR6 (TLR6) mRNA, encodes complete protein.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q9Y2C9 (Reactome details) participates in the following event(s):
R-HSA-168950 TLR6:TLR2 is recruited to ligand:CD14:CD36 R-HSA-8869667 oxLDL:CD36 binds TLR4:TLR6 R-HSA-2201316 Activated TLR2/4 interacts with MAL(TIRAP) R-HSA-166072 MyD88 forms a complex with MAL:activated TLR2/4 R-HSA-2201322 MAL is phosphorylated by BTK R-HSA-2559414 Activated TLR2/4:MAL interacts with BTK R-HSA-937079 MyD88 oligomerization within the complex of activated TLR:Mal:MyD88 R-HSA-166082 IRAK4 binds to the activated TLR receptor:Mal:MyD88 complex R-HSA-937022 IRAK4 autophosphorylation in the complex with activated TLR:MyD88:Mal R-HSA-166091 IRAK1 or IRAK2 binds to the activated IRAK4 :activated TLR:MyD88:Mal complex R-HSA-166362 Dissociation of hp-IRAK1:TRAF6 from the activated TLR:oligo-Myd88:Mal:p-IRAK4 complex R-HSA-2262775 Dissociation of p-IRAK2:TRAF6 from the activated TLR:oligo-Myd88:Mal:p-IRAK4 complex R-HSA-166286 Multiple IRAK1 autophosphorylation steps R-HSA-166284 Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal R-HSA-166119 First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal R-HSA-166363 TRAF6 binds to hp- IRAK1 R-HSA-937059 Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:Mal:activated TLR complex R-HSA-2262777 TRAF6 binds to p-IRAK2 R-HSA-168188 Toll Like Receptor TLR6:TLR2 Cascade R-HSA-5686938 Regulation of TLR by endogenous ligand R-HSA-181438 Toll Like Receptor 2 (TLR2) Cascade R-HSA-168898 Toll-Like Receptors Cascades R-HSA-166058 MyD88:Mal cascade initiated on plasma membrane R-HSA-168249 Innate Immune System R-HSA-5602498 MyD88 deficiency (TLR2/4) R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade R-HSA-168179 Toll Like Receptor TLR1:TLR2 Cascade R-HSA-168256 Immune System R-HSA-5603041 IRAK4 deficiency (TLR2/4) R-HSA-5602358 Diseases associated with the TLR signaling cascade R-HSA-5260271 Diseases of Immune System R-HSA-1643685 Disease
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
