Human Gene THY1 (ENST00000284240.10_7) from GENCODE V47lift37

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Description: Thy-1 cell surface antigen, transcript variant 1 (from RefSeq NM_006288.5)
Gencode Transcript: ENST00000284240.10_7
Gencode Gene: ENSG00000154096.14_13
Transcript (Including UTRs)
Position: hg19 chr11:119,286,186-119,293,882 Size: 7,697 Total Exon Count: 4 Strand: -
Coding Region
Position: hg19 chr11:119,290,118-119,291,615 Size: 1,498 Coding Exon Count: 3

Page Index	Sequence and Links	UniProtKB Comments	Primers	MalaCards	CTD
Gene Alleles	RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species
GO Annotations	mRNA Descriptions	Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr11:119,286,186-119,293,882)			mRNA (may differ from genome)		Protein (161 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Malacards	MGI	OMIM	PubMed	Reactome
UniProtKB	Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: THY1_HUMAN DESCRIPTION: RecName: Full=Thy-1 membrane glycoprotein; AltName: Full=CDw90; AltName: Full=Thy-1 antigen; AltName: CD_antigen=CD90; Flags: Precursor; FUNCTION: May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain. SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor (By similarity). SIMILARITY: Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: THY1 Diseases sorted by gene-association score: nasopharyngeal carcinoma (4), thymoma (4), warthin tumor (2), gerstmann-straussler disease (1), murray valley encephalitis (1), granulomatous angiitis (1), cd45 deficiency (1)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D003993 Dibutyl Phthalate D004997 Ethinyl Estradiol D011374 Progesterone D020849 Raloxifene D014212 Tretinoin D015073 2-Acetylaminofluorene C547126 AZM551248 D000643 Ammonium Chloride D001564 Benzo(a)pyrene D002251 Carbon Tetrachloride more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 174.89 RPKM in Brain - Frontal Cortex (BA9) Total median expression: 1602.08 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-28.60	84	-0.340	Picture	PostScript	Text
3' UTR	-1534.90	3932	-0.390	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR007110 - Ig-like
IPR013783 - Ig-like_fold
IPR003599 - Ig_sub
IPR013151 - Immunoglobulin

Pfam Domains:
PF00047 - Immunoglobulin domain

SCOP Domains:
48726 - Immunoglobulin

ModBase Predicted Comparative 3D Structure on P04216


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0005096 GTPase activator activity GO:0005178 integrin binding GO:0005515 protein binding GO:0019899 enzyme binding GO:0019901 protein kinase binding GO:0034235 GPI anchor binding Biological Process: GO:0001525 angiogenesis GO:0001952 regulation of cell-matrix adhesion GO:0002693 positive regulation of cellular extravasation GO:0006469 negative regulation of protein kinase activity GO:0007010 cytoskeleton organization GO:0007155 cell adhesion GO:0007229 integrin-mediated signaling pathway GO:0007267 cell-cell signaling GO:0030334 regulation of cell migration GO:0030336 negative regulation of cell migration GO:0034116 positive regulation of heterotypic cell-cell adhesion GO:0043113 receptor clustering GO:0043547 positive regulation of GTPase activity GO:0046549 retinal cone cell development GO:0046777 protein autophosphorylation GO:0048041 focal adhesion assembly GO:0050771 negative regulation of axonogenesis GO:0050852 T cell receptor signaling pathway GO:0050860 negative regulation of T cell receptor signaling pathway GO:0050870 positive regulation of T cell activation GO:0051281 positive regulation of release of sequestered calcium ion into cytosol GO:0051894 positive regulation of focal adhesion assembly GO:0061099 negative regulation of protein tyrosine kinase activity GO:0070571 negative regulation of neuron projection regeneration GO:0098609 cell-cell adhesion GO:2000298 regulation of Rho-dependent protein serine/threonine kinase activity Cellular Component: GO:0005576 extracellular region GO:0005783 endoplasmic reticulum GO:0005829 cytosol GO:0005886 plasma membrane GO:0005887 integral component of plasma membrane GO:0005925 focal adhesion GO:0009897 external side of plasma membrane GO:0009986 cell surface GO:0016020 membrane GO:0016324 apical plasma membrane GO:0030425 dendrite GO:0030426 growth cone GO:0030673 axolemma GO:0031225 anchored component of membrane GO:0031362 anchored component of external side of plasma membrane GO:0032590 dendrite membrane GO:0032809 neuronal cell body membrane GO:0043209 myelin sheath GO:0045121 membrane raft GO:0046658 anchored component of plasma membrane GO:0070062 extracellular exosome

Descriptions from all associated GenBank mRNAs


	JD478540 - Sequence 459564 from Patent EP1572962. JD543230 - Sequence 524254 from Patent EP1572962. JD537271 - Sequence 518295 from Patent EP1572962. JD463783 - Sequence 444807 from Patent EP1572962. JD478541 - Sequence 459565 from Patent EP1572962. JD543231 - Sequence 524255 from Patent EP1572962. AK094374 - Homo sapiens cDNA FLJ37055 fis, clone BRACE2014161, highly similar to Homo sapiens Thy-1 glycoprotein and Thy-1 co-transcribed protein mRNAs. BC009328 - Homo sapiens cDNA clone IMAGE:4125908, ** WARNING: chimeric clone . AK057865 - Homo sapiens cDNA FLJ25136 fis, clone CBR07030, highly similar to THY-1 MEMBRANE GLYCOPROTEIN PRECURSOR. AK090996 - Homo sapiens cDNA FLJ33677 fis, clone BRAWH2002125, highly similar to THY-1 MEMBRANE GLYCOPROTEIN PRECURSOR. AL161958 - Homo sapiens mRNA; cDNA DKFZp761B15121 (from clone DKFZp761B15121). BC005175 - Homo sapiens Thy-1 cell surface antigen, mRNA (cDNA clone IMAGE:3507917), WARNING: chimeric clone . AF261093 - Homo sapiens Thy-1 glycoprotein and Thy-1 co-transcribed protein mRNAs, complete cds. BC062593 - Homo sapiens cDNA clone IMAGE:5225379, WARNING: chimeric clone . BC037832 - Homo sapiens Thy-1 cell surface antigen, mRNA (cDNA clone IMAGE:4812471), WARNING: chimeric clone **. JD328041 - Sequence 309065 from Patent EP1572962. JD243558 - Sequence 224582 from Patent EP1572962. JD283593 - Sequence 264617 from Patent EP1572962. JD283592 - Sequence 264616 from Patent EP1572962. JD556632 - Sequence 537656 from Patent EP1572962. JD232046 - Sequence 213070 from Patent EP1572962. AK314018 - Homo sapiens cDNA, FLJ94676, Homo sapiens Thy-1 co-transcribed (LOC94105), mRNA. JD456143 - Sequence 437167 from Patent EP1572962. JD335017 - Sequence 316041 from Patent EP1572962. JD103099 - Sequence 84123 from Patent EP1572962. JD159923 - Sequence 140947 from Patent EP1572962. JD326586 - Sequence 307610 from Patent EP1572962. JD490336 - Sequence 471360 from Patent EP1572962. JD222628 - Sequence 203652 from Patent EP1572962. JD344221 - Sequence 325245 from Patent EP1572962. JD098314 - Sequence 79338 from Patent EP1572962. JD051764 - Sequence 32788 from Patent EP1572962. JD187944 - Sequence 168968 from Patent EP1572962. JD088390 - Sequence 69414 from Patent EP1572962. JD088389 - Sequence 69413 from Patent EP1572962. JD045463 - Sequence 26487 from Patent EP1572962. BC065559 - Homo sapiens Thy-1 cell surface antigen, mRNA (cDNA clone MGC:74728 IMAGE:6137513), complete cds. AB209209 - Homo sapiens mRNA for Thy-1 cell surface antigen variant protein. AK090644 - Homo sapiens cDNA FLJ33325 fis, clone BNGH42008832, highly similar to THY-1 MEMBRANE GLYCOPROTEIN PRECURSOR. JD187963 - Sequence 168987 from Patent EP1572962. JD399314 - Sequence 380338 from Patent EP1572962. JD106983 - Sequence 88007 from Patent EP1572962. JD340617 - Sequence 321641 from Patent EP1572962. JD485998 - Sequence 467022 from Patent EP1572962. JD295395 - Sequence 276419 from Patent EP1572962. JD525677 - Sequence 506701 from Patent EP1572962. JD520274 - Sequence 501298 from Patent EP1572962. JD413161 - Sequence 394185 from Patent EP1572962. JD126848 - Sequence 107872 from Patent EP1572962. JD054837 - Sequence 35861 from Patent EP1572962. JD175783 - Sequence 156807 from Patent EP1572962. JD131356 - Sequence 112380 from Patent EP1572962. JD023548 - Sequence 4572 from Patent EP1572962. JD190464 - Sequence 171488 from Patent EP1572962. JD498711 - Sequence 479735 from Patent EP1572962. JD279168 - Sequence 260192 from Patent EP1572962. KJ892277 - Synthetic construct Homo sapiens clone ccsbBroadEn_01671 THY1 gene, encodes complete protein. DQ895011 - Synthetic construct Homo sapiens clone IMAGE:100009471; FLH180305.01L; RZPDo839A10133D Thy-1 cell surface antigen (THY1) gene, encodes complete protein. DQ895013 - Synthetic construct Homo sapiens clone IMAGE:100009473; FLH263688.01L; RZPDo839A12133D Thy-1 cell surface antigen (THY1) gene, encodes complete protein. EU176310 - Synthetic construct Homo sapiens clone IMAGE:100006411; FLH180309.01X; RZPDo839A10134D Thy-1 cell surface antigen (THY1) gene, encodes complete protein. AB528296 - Synthetic construct DNA, clone: pF1KE0419, Homo sapiens THY1 gene for Thy-1 cell surface antigen, without stop codon, in Flexi system. AM393032 - Synthetic construct Homo sapiens clone IMAGE:100001920 for hypothetical protein (THY1 gene). AM393214 - Synthetic construct Homo sapiens clone IMAGE:100001915 for hypothetical protein (THY1 gene). JD464797 - Sequence 445821 from Patent EP1572962. JD424057 - Sequence 405081 from Patent EP1572962. JD031520 - Sequence 12544 from Patent EP1572962. JD322156 - Sequence 303180 from Patent EP1572962. JD496094 - Sequence 477118 from Patent EP1572962. JD456269 - Sequence 437293 from Patent EP1572962. JD411167 - Sequence 392191 from Patent EP1572962. JD474188 - Sequence 455212 from Patent EP1572962. JD154522 - Sequence 135546 from Patent EP1572962. JD025614 - Sequence 6638 from Patent EP1572962. S59749 - Homo sapiens 5E10 antigen (Thy-1) mRNA, partial cds. JD029179 - Sequence 10203 from Patent EP1572962. JD142517 - Sequence 123541 from Patent EP1572962. JD045941 - Sequence 26965 from Patent EP1572962. JD333797 - Sequence 314821 from Patent EP1572962. JD079355 - Sequence 60379 from Patent EP1572962.

Biochemical and Signaling Pathways


	BioCarta from NCI Cancer Genome Anatomy Project h_tcytotoxicPathway - T Cytotoxic Cell Surface Molecules h_thelperPathway - T Helper Cell Surface Molecules Reactome (by CSHL, EBI, and GO) Protein P04216 (Reactome details) participates in the following event(s): R-HSA-8940388 GPLD1 hydrolyses GPI-anchors from proteins R-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins R-HSA-597592 Post-translational protein modification R-HSA-392499 Metabolism of proteins

Other Names for This Gene


	Alternate Gene Symbols: ENST00000284240.1, ENST00000284240.2, ENST00000284240.3, ENST00000284240.4, ENST00000284240.5, ENST00000284240.6, ENST00000284240.7, ENST00000284240.8, ENST00000284240.9, NM_006288, P04216, Q16008, Q9NSP1, THY1_HUMAN, uc317keh.1, uc317keh.2 UCSC ID: ENST00000284240.10_7 RefSeq Accession: NM_006288.5 Protein: P04216 (aka THY1_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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