Human Gene TGM7 (ENST00000452443.3_7) from GENCODE V47lift37
  Description: transglutaminase 7 (from RefSeq NM_052955.3)
Gencode Transcript: ENST00000452443.3_7
Gencode Gene: ENSG00000159495.8_9
Transcript (Including UTRs)
   Position: hg19 chr15:43,568,469-43,594,453 Size: 25,985 Total Exon Count: 13 Strand: -
Coding Region
   Position: hg19 chr15:43,568,653-43,594,448 Size: 25,796 Coding Exon Count: 13 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr15:43,568,469-43,594,453)mRNA (may differ from genome)Protein (710 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: TGM7_HUMAN
DESCRIPTION: RecName: Full=Protein-glutamine gamma-glutamyltransferase Z; AltName: Full=Transglutaminase Z; Short=TG(Z); Short=TGZ; Short=TGase Z; EC=2.3.2.13; AltName: Full=Transglutaminase-7; Short=TGase-7;
FUNCTION: Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins.
CATALYTIC ACTIVITY: Protein glutamine + alkylamine = protein N(5)- alkylglutamine + NH(3).
COFACTOR: Binds 1 calcium ion per subunit (By similarity).
TISSUE SPECIFICITY: Widely expressed.
SIMILARITY: Belongs to the transglutaminase superfamily. Transglutaminase family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 1.99 RPKM in Testis
Total median expression: 2.44 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
3' UTR -36.40184-0.198 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR023608 - Gln_gamma-glutamylTfrase_euk
IPR013783 - Ig-like_fold
IPR014756 - Ig_E-set
IPR002931 - Transglutaminase-like
IPR008958 - Transglutaminase_C
IPR013808 - Transglutaminase_CS
IPR001102 - Transglutaminase_N

Pfam Domains:
PF00868 - Transglutaminase family
PF00927 - Transglutaminase family, C-terminal ig like domain
PF01841 - Transglutaminase-like superfamily

SCOP Domains:
81296 - E set domains
49309 - Transglutaminase, two C-terminal domains
54001 - Cysteine proteinases

ModBase Predicted Comparative 3D Structure on Q96PF1
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003810 protein-glutamine gamma-glutamyltransferase activity
GO:0016740 transferase activity
GO:0016746 transferase activity, transferring acyl groups
GO:0046872 metal ion binding

Biological Process:
GO:0018149 peptide cross-linking


-  Descriptions from all associated GenBank mRNAs
  AF363393 - Homo sapiens transglutaminase Z (TGM7) mRNA, complete cds.
JD543428 - Sequence 524452 from Patent EP1572962.
JD494596 - Sequence 475620 from Patent EP1572962.
JD227921 - Sequence 208945 from Patent EP1572962.
JD405904 - Sequence 386928 from Patent EP1572962.
JD128862 - Sequence 109886 from Patent EP1572962.
JD257467 - Sequence 238491 from Patent EP1572962.
BC148502 - Synthetic construct Homo sapiens clone IMAGE:100015481, MGC:183054 transglutaminase 7 (TGM7) mRNA, encodes complete protein.
BC153105 - Synthetic construct Homo sapiens clone IMAGE:100016478, MGC:184267 transglutaminase 7 (TGM7) mRNA, encodes complete protein.
AB527226 - Synthetic construct DNA, clone: pF1KE0382, Homo sapiens TGM7 gene for transglutaminase 7, without stop codon, in Flexi system.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000452443.1, ENST00000452443.2, NM_052955, Q96PF1, TGM7_HUMAN, uc320tso.1, uc320tso.2
UCSC ID: ENST00000452443.3_7
RefSeq Accession: NM_052955.3
Protein: Q96PF1 (aka TGM7_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.