ID:TFAP4_HUMAN DESCRIPTION: RecName: Full=Transcription factor AP-4; AltName: Full=Activating enhancer-binding protein 4; AltName: Full=Class C basic helix-loop-helix protein 41; Short=bHLHc41; FUNCTION: Transcription factor that activates both viral and cellular genes by binding to the symmetrical DNA sequence 5'- CAGCTG-3'. SUBUNIT: Efficient DNA binding requires dimerization with another bHLH protein. Homodimer. SUBCELLULAR LOCATION: Nucleus. SIMILARITY: Contains 1 bHLH (basic helix-loop-helix) domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q01664
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0003677 DNA binding GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding GO:0005515 protein binding GO:0042803 protein homodimerization activity GO:0042826 histone deacetylase binding GO:0043565 sequence-specific DNA binding GO:0044212 transcription regulatory region DNA binding GO:0046983 protein dimerization activity GO:0070888 E-box binding GO:0003713 transcription coactivator activity GO:0046982 protein heterodimerization activity
Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006366 transcription from RNA polymerase II promoter GO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0008285 negative regulation of cell proliferation GO:0010629 negative regulation of gene expression GO:0043065 positive regulation of apoptotic process GO:0043392 negative regulation of DNA binding GO:0043922 negative regulation by host of viral transcription GO:0043923 positive regulation by host of viral transcription GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045892 negative regulation of transcription, DNA-templated GO:0045893 positive regulation of transcription, DNA-templated GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0065003 macromolecular complex assembly GO:0071157 negative regulation of cell cycle arrest GO:0071549 cellular response to dexamethasone stimulus GO:1901990 regulation of mitotic cell cycle phase transition GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
