ID:AP2E_HUMAN DESCRIPTION: RecName: Full=Transcription factor AP-2-epsilon; Short=AP2-epsilon; AltName: Full=Activating enhancer-binding protein 2-epsilon; FUNCTION: Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-epsilon may play a role in the development of the CNS and in cartilage differentiation (By similarity). SUBUNIT: Binds DNA as a dimer. Can form homodimers or heterodimers with other AP-2 family members (By similarity). SUBCELLULAR LOCATION: Nucleus (By similarity). TISSUE SPECIFICITY: Expressed in skin, primary keratinocytes, immortalized keratinocytes, and HeLa cell line. SIMILARITY: Belongs to the AP-2 family. SEQUENCE CAUTION: Sequence=AAH41175.1; Type=Erroneous initiation; Sequence=EAX07409.1; Type=Erroneous gene model prediction; WEB RESOURCE: Name=Wikipedia; Note=Activatin protein 2 entry; URL="http://en.wikipedia.org/wiki/Activating_protein_2";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q6VUC0
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0042803 protein homodimerization activity GO:0046982 protein heterodimerization activity
Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006366 transcription from RNA polymerase II promoter GO:0042127 regulation of cell proliferation GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0048856 anatomical structure development
AY326454 - Homo sapiens transcription factor AP-2 epsilon mRNA, complete cds. BC041175 - Homo sapiens transcription factor AP-2 epsilon (activating enhancer binding protein 2 epsilon), mRNA (cDNA clone MGC:49007 IMAGE:5786430), complete cds. BC150147 - Homo sapiens cDNA clone IMAGE:40133229. JD376463 - Sequence 357487 from Patent EP1572962. JD523825 - Sequence 504849 from Patent EP1572962. JD482438 - Sequence 463462 from Patent EP1572962. JD201681 - Sequence 182705 from Patent EP1572962. JD446163 - Sequence 427187 from Patent EP1572962. JD264037 - Sequence 245061 from Patent EP1572962. JD279040 - Sequence 260064 from Patent EP1572962. JD206460 - Sequence 187484 from Patent EP1572962. JD434017 - Sequence 415041 from Patent EP1572962. JD154539 - Sequence 135563 from Patent EP1572962. JD304981 - Sequence 286005 from Patent EP1572962. JD171533 - Sequence 152557 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q6VUC0 (Reactome details) participates in the following event(s):
R-HSA-8864278 AP-2 (TFAP2) transcription factors form homo- and heterodimers R-HSA-8864307 TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP R-HSA-8864343 KCTD1 binds TFAP2 homo- and heterodimers R-HSA-8864361 KCTD15 binds TFAP2 homo- and heterodimers R-HSA-8866907 Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866904 Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8864260 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-212436 Generic Transcription Pathway R-HSA-73857 RNA Polymerase II Transcription R-HSA-74160 Gene expression (Transcription)
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
