ID:AP2D_HUMAN DESCRIPTION: RecName: Full=Transcription factor AP-2-delta; Short=AP2-delta; AltName: Full=Activating enhancer-binding protein 2-delta; AltName: Full=Transcription factor AP-2-beta-like 1; FUNCTION: Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC (By similarity). SUBUNIT: Binds DNA as a dimer. Can form homodimers or heterodimers with other AP-2 family members (By similarity). SUBCELLULAR LOCATION: Nucleus (Probable). TISSUE SPECIFICITY: Highly expressed in brain, placenta, skeletal muscle, thymus, small intestine, and prostate, and expressed at lower levels in leukocyte, spleen, testis, ovary and colon. Barely detectable in heart, kidney, liver, lung or pancreas. SIMILARITY: Belongs to the AP-2 family. WEB RESOURCE: Name=Wikipedia; Note=Activatin protein 2 entry; URL="http://en.wikipedia.org/wiki/Activating_protein_2";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q7Z6R9
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding
Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0042127 regulation of cell proliferation GO:0043524 negative regulation of neuron apoptotic process GO:0045893 positive regulation of transcription, DNA-templated GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0048856 anatomical structure development GO:0061379 inferior colliculus development
AY028376 - Homo sapiens AP-2-like protein mRNA, complete cds. BC144200 - Homo sapiens cDNA clone IMAGE:9052720, containing frame-shift errors. BC166653 - Synthetic construct Homo sapiens clone IMAGE:100066379, MGC:195516 transcription factor AP-2 delta (activating enhancer binding protein 2 delta) (TFAP2D) mRNA, encodes complete protein. JD404468 - Sequence 385492 from Patent EP1572962. JD224096 - Sequence 205120 from Patent EP1572962. JD515901 - Sequence 496925 from Patent EP1572962. JD305029 - Sequence 286053 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q7Z6R9 (Reactome details) participates in the following event(s):
R-HSA-8864278 AP-2 (TFAP2) transcription factors form homo- and heterodimers R-HSA-8864307 TFAP2 homo- and heterodimers bind CITED and EP300/CREBBP R-HSA-8864343 KCTD1 binds TFAP2 homo- and heterodimers R-HSA-8864361 KCTD15 binds TFAP2 homo- and heterodimers R-HSA-8866907 Activation of the TFAP2 (AP-2) family of transcription factors R-HSA-8866904 Negative regulation of activity of TFAP2 (AP-2) family transcription factors R-HSA-8864260 Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors R-HSA-212436 Generic Transcription Pathway R-HSA-73857 RNA Polymerase II Transcription R-HSA-74160 Gene expression (Transcription)
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
