Human Gene DYNLT2B (ENST00000325318.10_7) from GENCODE V47lift37
  Description: dynein light chain Tctex-type 2B, transcript variant 2 (from RefSeq NM_152773.5)
Gencode Transcript: ENST00000325318.10_7
Gencode Gene: ENSG00000213123.11_11
Transcript (Including UTRs)
   Position: hg19 chr3:196,018,090-196,045,111 Size: 27,022 Total Exon Count: 5 Strand: -
Coding Region
   Position: hg19 chr3:196,018,198-196,045,023 Size: 26,826 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersGene AllelesRNA-Seq Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathways
Other NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:196,018,090-196,045,111)mRNA (may differ from genome)Protein (142 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsMGI
OMIMPubMedReactomeUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: TC1D2_HUMAN
DESCRIPTION: RecName: Full=Tctex1 domain-containing protein 2;
INTERACTION: P13984:GTF2F2; NbExp=2; IntAct=EBI-2692044, EBI-1030560;
SIMILARITY: Belongs to the dynein light chain Tctex-type family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 9.28 RPKM in Testis
Total median expression: 125.90 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -21.8088-0.248 Picture PostScript Text
3' UTR -11.60108-0.107 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR005334 - Tctex

Pfam Domains:
PF03645 - Tctex-1 family

ModBase Predicted Comparative 3D Structure on Q8WW35
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologGenome BrowserNo ortholog
Gene DetailsGene Details Gene DetailsGene Details 
Gene SorterGene Sorter Gene SorterGene Sorter 
 RGDEnsembl WormBase 
    Protein Sequence 
    Alignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0045505 dynein intermediate chain binding

Biological Process:
GO:0060271 cilium assembly
GO:1902017 regulation of cilium assembly

Cellular Component:
GO:0005868 cytoplasmic dynein complex
GO:0000922 spindle pole
GO:0005813 centrosome
GO:0005930 axoneme
GO:0031021 interphase microtubule organizing center
GO:0097546 ciliary base


-  Descriptions from all associated GenBank mRNAs
  BC021177 - Homo sapiens Tctex1 domain containing 2, mRNA (cDNA clone MGC:33212 IMAGE:4830500), complete cds.
KJ900515 - Synthetic construct Homo sapiens clone ccsbBroadEn_09909 TCTEX1D2 gene, encodes complete protein.
BC013113 - Homo sapiens transmembrane 4 L six family member 19, mRNA (cDNA clone IMAGE:3924581).
BC015348 - Homo sapiens transmembrane 4 L six family member 19, mRNA (cDNA clone IMAGE:4415302), partial cds.
JD208207 - Sequence 189231 from Patent EP1572962.
JD412448 - Sequence 393472 from Patent EP1572962.
JD197682 - Sequence 178706 from Patent EP1572962.
JD284132 - Sequence 265156 from Patent EP1572962.
JD293662 - Sequence 274686 from Patent EP1572962.
JD211202 - Sequence 192226 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q8WW35 (Reactome details) participates in the following event(s):

R-HSA-5624949 Assembly of the anterograde IFT train
R-HSA-5625424 The retrograde IFT train dissociates
R-HSA-5625421 The anterograde IFT train dissociates
R-HSA-5624952 Assembly of the retrograde IFT train
R-HSA-5620924 Intraflagellar transport
R-HSA-5617833 Cilium Assembly
R-HSA-1852241 Organelle biogenesis and maintenance

-  Other Names for This Gene
  Alternate Gene Symbols: A6NCN5, DYNLT2B , DYT2B_HUMAN, ENST00000325318.1, ENST00000325318.2, ENST00000325318.3, ENST00000325318.4, ENST00000325318.5, ENST00000325318.6, ENST00000325318.7, ENST00000325318.8, ENST00000325318.9, NM_152773, Q8WW35, TCTEX1D2 , uc317rvt.1, uc317rvt.2
UCSC ID: ENST00000325318.10_7
RefSeq Accession: NM_152773.5
Protein: Q8WW35 (aka TC1D2_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.