ID:TF7L1_HUMAN DESCRIPTION: RecName: Full=Transcription factor 7-like 1; AltName: Full=HMG box transcription factor 3; Short=TCF-3; FUNCTION: Participates in the Wnt signaling pathway. Binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. Necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis (By similarity). Down-regulates NQO1, leading to increased mitomycin c resistance. SUBUNIT: Binds the armadillo repeat of CTNNB1 and forms a stable complex (By similarity). SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Detected in hair follicles and skin keratinocytes, and at lower levels in stomach epithelium. DOMAIN: The putative Groucho interaction domain between the N- terminal CTNNB1 binding domain and the HMG-box is necessary for repression of the transactivation mediated by TCF7L1 and CTNNB1 (By similarity). SIMILARITY: Belongs to the TCF/LEF family. SIMILARITY: Contains 1 HMG box DNA-binding domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9HCS4
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0008013 beta-catenin binding GO:0043565 sequence-specific DNA binding GO:0044212 transcription regulatory region DNA binding
Biological Process: GO:0006325 chromatin organization GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0016055 Wnt signaling pathway GO:0030111 regulation of Wnt signaling pathway GO:0060070 canonical Wnt signaling pathway GO:1904837 beta-catenin-TCF complex assembly
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
