Human Gene TCF24 (ENST00000563496.2_7) from GENCODE V47lift37

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Description: transcription factor 24 (from RefSeq NM_001193502.2)
Gencode Transcript: ENST00000563496.2_7
Gencode Gene: ENSG00000261787.2_9
Transcript (Including UTRs)
Position: hg19 chr8:67,858,736-67,874,826 Size: 16,091 Total Exon Count: 4 Strand: -
Coding Region
Position: hg19 chr8:67,860,286-67,874,000 Size: 13,715 Coding Exon Count: 2

Page Index	Sequence and Links	UniProtKB Comments	Primers	Gene Alleles	RNA-Seq Expression
Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations	mRNA Descriptions
Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr8:67,858,736-67,874,826)			mRNA (may differ from genome)		Protein (167 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	PubMed	UniProtKB	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: TCF24_HUMAN DESCRIPTION: RecName: Full=Transcription factor 24; Short=TCF-24; FUNCTION: Putative transcription factor (By similarity). SUBUNIT: Efficient DNA binding requires dimerization with another bHLH protein (By similarity). SUBCELLULAR LOCATION: Nucleus (By similarity). SIMILARITY: Contains 1 bHLH (basic helix-loop-helix) domain. SEQUENCE CAUTION: Sequence=DAA00306.1; Type=Erroneous gene model prediction;

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 1.31 RPKM in Testis Total median expression: 2.97 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-174.30	397	-0.439	Picture	PostScript	Text
3' UTR	-353.20	1550	-0.228	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR011598 - HLH_dom

Pfam Domains:
PF00010 - Helix-loop-helix DNA-binding domain

SCOP Domains:
47459 - HLH, helix-loop-helix DNA-binding domain

ModBase Predicted Comparative 3D Structure on Q7RTU0


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD	Ensembl

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0003677 DNA binding GO:0046983 protein dimerization activity Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated Cellular Component: GO:0005634 nucleus

Descriptions from all associated GenBank mRNAs

Other Names for This Gene


	Alternate Gene Symbols: ENST00000563496.1, H3BPR9, NM_001193502, Q7RTU0, TCF24_HUMAN, uc325san.1, uc325san.2 UCSC ID: ENST00000563496.2_7 RefSeq Accession: NM_001193502.2 Protein: Q7RTU0 (aka TCF24_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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