Human Gene ELOC (ENST00000284811.12_5) from GENCODE V47lift37
Description: SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) (PubMed:7821821). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an important feature of pluripotent stem cells (By similarity). (from UniProt Q15369) Gencode Transcript: ENST00000284811.12_5 Gencode Gene: ENSG00000154582.18_12 Transcript (Including UTRs) Position: hg19 chr8:74,858,636-74,884,341 Size: 25,706 Total Exon Count: 4 Strand: - Coding Region Position: hg19 chr8:74,858,865-74,872,003 Size: 13,139 Coding Exon Count: 3
ID:ELOC_HUMAN DESCRIPTION: RecName: Full=Transcription elongation factor B polypeptide 1; AltName: Full=Elongin 15 kDa subunit; AltName: Full=Elongin-C; Short=EloC; AltName: Full=RNA polymerase II transcription factor SIII subunit C; AltName: Full=SIII p15; FUNCTION: SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex). FUNCTION: The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC- box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes. SUBUNIT: Heterotrimer of an A (A1, A2 or A3), B and C subunit. Part of E3 ubiquitin ligase complexes with CUL5 or CUL2, RBX1 and a substrate adapter protein that can be either SOCS1, SOCS5, TCEB3, VHL or WSB1 (By similarity). The elongin BC complex is part of a complex with hydroxylated HIF1A. Substrate adapter protein can be a viral protein such as HIV Vif. Interacts with VHL. Interacts with TMF1. Interacts with human respiratory syncytial virus (HRSV) protein NS1. INTERACTION: Q96G25:MED8; NbExp=3; IntAct=EBI-301231, EBI-394405; Q99619:SPSB2; NbExp=3; IntAct=EBI-301231, EBI-2323209; Q96A44:SPSB4; NbExp=2; IntAct=EBI-301231, EBI-2323233; Q15370:TCEB2; NbExp=3; IntAct=EBI-301231, EBI-301238; P12504:vif (xeno); NbExp=5; IntAct=EBI-301231, EBI-779991; SUBCELLULAR LOCATION: Nucleus (Probable). TISSUE SPECIFICITY: Overexpressed in prostate cancer cell line PC- 3 and breast cancer cell line SK-BR-3. SIMILARITY: Belongs to the SKP1 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q15369
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005515 protein binding GO:0004842 ubiquitin-protein transferase activity
Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0006366 transcription from RNA polymerase II promoter GO:0006368 transcription elongation from RNA polymerase II promoter GO:0006511 ubiquitin-dependent protein catabolic process GO:0016032 viral process GO:0016567 protein ubiquitination GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter GO:0043687 post-translational protein modification GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia
AK057889 - Homo sapiens cDNA FLJ25160 fis, clone CBR08077, highly similar to Rat elongation factor SIII p15 subunit mRNA. LF383592 - JP 2014500723-A/191095: Polycomb-Associated Non-Coding RNAs. AL832244 - Homo sapiens mRNA; cDNA DKFZp686L1077 (from clone DKFZp686L1077). BX649138 - Homo sapiens mRNA; cDNA DKFZp686J19157 (from clone DKFZp686J19157). BC100283 - Homo sapiens transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C), mRNA (cDNA clone MGC:117336 IMAGE:6061521), complete cds. BC013809 - Homo sapiens transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C), mRNA (cDNA clone MGC:8963 IMAGE:3923736), complete cds. BC093065 - Homo sapiens transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C), mRNA (cDNA clone MGC:111173 IMAGE:30411791), complete cds. L34587 - Homo sapiens RNA polymerase II elongation factor SIII, p15 subunit mRNA, complete cds. EU176247 - Synthetic construct Homo sapiens clone IMAGE:100006361; FLH168553.01X; RZPDo839E08250D transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C) (TCEB1) gene, encodes complete protein. DQ894197 - Synthetic construct Homo sapiens clone IMAGE:100008657; FLH168548.01L; RZPDo839A0893D transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C) (TCEB1) gene, encodes complete protein. AB464300 - Synthetic construct DNA, clone: pF1KB7509, Homo sapiens TCEB1 gene for transcription elongation factor B (SIII), polypeptide 1, without stop codon, in Flexi system. LF317115 - JP 2014500723-A/124618: Polycomb-Associated Non-Coding RNAs. LF317116 - JP 2014500723-A/124619: Polycomb-Associated Non-Coding RNAs. LF317117 - JP 2014500723-A/124620: Polycomb-Associated Non-Coding RNAs. MA619169 - JP 2018138019-A/191095: Polycomb-Associated Non-Coding RNAs. MA552692 - JP 2018138019-A/124618: Polycomb-Associated Non-Coding RNAs. MA552693 - JP 2018138019-A/124619: Polycomb-Associated Non-Coding RNAs. MA552694 - JP 2018138019-A/124620: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q15369 (Reactome details) participates in the following event(s):
R-HSA-112435 Formation of Elongin BC complex R-HSA-112436 Formation of Elongin complex R-HSA-180555 Association of APOBEC3G:Vif with the Cul5-SCF complex R-HSA-112379 Recruitment of elongation factors to form elongation complex R-HSA-167077 Recruitment of elongation factors to form HIV-1 elongation complex R-HSA-167196 Recruitment of elongation factors to form HIV-1 elongation complex R-HSA-113429 Elongating transcript encounters a lesion in the template R-HSA-1234169 Nuclear VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha R-HSA-180540 Multi-ubiquitination of APOBEC3G R-HSA-8956099 VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7 R-HSA-8956103 VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha R-HSA-983157 Interaction of E3 with substrate and E2-Ub complex R-HSA-983147 Release of E3 from polyubiquitinated substrate R-HSA-8955241 CAND1 binds cytosolic CRL E3 ubiquitin ligases R-HSA-8952039 NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex R-HSA-8952044 AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex R-HSA-112385 Addition of nucleotides leads to transcript elongation R-HSA-113411 2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing R-HSA-113412 Pol II elongation complex moves on the template as transcript elongates R-HSA-113414 7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest R-HSA-112392 Resumption of elongation after recovery from pausing R-HSA-113413 TFIIS-mediated recovery of elongation from arrest R-HSA-112395 Abortive termination of elongation after arrest R-HSA-112396 Separation of elongating transcript from template R-HSA-167150 Resumption of elongation of HIV-1 transcript after recovery from pausing R-HSA-167076 2-4 nt.backtracking of Pol II complex on the HIV-1 template leading to elongation pausing R-HSA-167282 2-4 nt.backtracking of Pol II complex on the HIV-1 template leading to elongation pausing R-HSA-167284 7-14 nt. Backtracking of Pol II complex on the HIV-1 template leading to elongation arrest R-HSA-167288 TFIIS-mediated recovery of HIV-1 elongation from arrest R-HSA-167292 Resumption of elongation of HIV-1 transcript after recovery from pausing R-HSA-167148 TFIIS-mediated recovery of elongation from arrest R-HSA-167459 Abortive termination of HIV-1 elongation after arrest (Tat-containing elongation complex) R-HSA-167090 7-14 nt. Backtracking of Pol II complex on the HIV-1 template leading to elongation arrest R-HSA-167192 Pol II elongation complex moves on the HIV-1 template as transcript elongates R-HSA-167181 Addition of nucleotides leads to HIV-1 transcript elongation R-HSA-167197 Separation of elongating HIV-1 transcript from template R-HSA-167481 Abortive termination of HIV-1 elongation after arrest R-HSA-6797616 CCNK:CDK12 binds RNA Pol II at DNA repair genes R-HSA-1234172 Nuclear VBC complex ubiquitinylates HIF-alpha R-HSA-1234183 Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha R-HSA-8956106 VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha R-HSA-983140 Transfer of Ub from E2 to substrate and release of E2 R-HSA-8955289 COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes R-HSA-8956040 COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes R-HSA-6797606 CDK12 phosphorylates RNA Pol II CTD at DNA repair genes R-HSA-1234163 Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha R-HSA-1234173 Cytosolic PHD2,3 hydroxylates proline residues on HIF3A R-HSA-1234177 Cytosolic PHD2,3 hydroxylates proline residues on HIF1A R-HSA-1234179 Cytosolic PHD2,3 hydroxylates proline residues on EPAS1 (HIF2A) R-HSA-674695 RNA Polymerase II Pre-transcription Events R-HSA-73857 RNA Polymerase II Transcription R-HSA-180585 Vif-mediated degradation of APOBEC3G R-HSA-9010553 Regulation of expression of SLITs and ROBOs R-HSA-112382 Formation of RNA Pol II elongation complex R-HSA-167152 Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167200 Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-74160 Gene expression (Transcription) R-HSA-162909 Host Interactions of HIV factors R-HSA-8951664 Neddylation R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation R-HSA-376176 Signaling by ROBO receptors R-HSA-75955 RNA Polymerase II Transcription Elongation R-HSA-167238 Pausing and recovery of Tat-mediated HIV elongation R-HSA-167290 Pausing and recovery of HIV elongation R-HSA-167287 HIV elongation arrest and recovery R-HSA-167243 Tat-mediated HIV elongation arrest and recovery R-HSA-167246 Tat-mediated elongation of the HIV-1 transcript R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes R-HSA-167172 Transcription of the HIV genome R-HSA-1234174 Regulation of Hypoxia-inducible Factor (HIF) by oxygen R-HSA-162906 HIV Infection R-HSA-597592 Post-translational protein modification R-HSA-983169 Class I MHC mediated antigen processing & presentation R-HSA-422475 Axon guidance R-HSA-167169 HIV Transcription Elongation R-HSA-3700989 Transcriptional Regulation by TP53 R-HSA-162599 Late Phase of HIV Life Cycle R-HSA-2262749 Cellular response to hypoxia R-HSA-5663205 Infectious disease R-HSA-392499 Metabolism of proteins R-HSA-1280218 Adaptive Immune System R-HSA-1266738 Developmental Biology R-HSA-212436 Generic Transcription Pathway R-HSA-162587 HIV Life Cycle R-HSA-2262752 Cellular responses to stress R-HSA-1643685 Disease R-HSA-168256 Immune System R-HSA-8953897 Cellular responses to external stimuli
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Common Gene Haplotype Alleles 
