Human Gene TCEANC (ENST00000696128.1_3) from GENCODE V47lift37
  Description: transcription elongation factor A N-terminal and central domain containing, transcript variant 2 (from RefSeq NM_001297563.2)
Gencode Transcript: ENST00000696128.1_3
Gencode Gene: ENSG00000176896.9_13
Transcript (Including UTRs)
   Position: hg19 chrX:13,671,260-13,683,528 Size: 12,269 Total Exon Count: 5 Strand: +
Coding Region
   Position: hg19 chrX:13,680,628-13,681,683 Size: 1,056 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Model InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chrX:13,671,260-13,683,528)mRNA (may differ from genome)Protein (351 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: TEANC_HUMAN
DESCRIPTION: RecName: Full=Transcription elongation factor A N-terminal and central domain-containing protein; AltName: Full=TFIIS central domain-containing protein 1;
SIMILARITY: Contains 1 TFIIS central domain.
SIMILARITY: Contains 1 TFIIS N-terminal domain.
SEQUENCE CAUTION: Sequence=BAC04930.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -121.50350-0.347 Picture PostScript Text
3' UTR -480.701845-0.261 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR016492 - TF_IIS-rel
IPR003618 - TFIIS_cen_dom
IPR017923 - TFIIS_N

Pfam Domains:
PF07500 - Transcription factor S-II (TFIIS), central domain
PF08711 - TFIIS helical bundle-like domain

SCOP Domains:
47676 - Conserved domain common to transcription factors TFIIS, elongin A, CRSP70
140576 - HIV integrase-binding domain
46942 - Elongation factor TFIIS domain 2
57783 - Zinc beta-ribbon

ModBase Predicted Comparative 3D Structure on Q8N8B7
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Biological Process:
GO:0006351 transcription, DNA-templated

Cellular Component:
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  AK291271 - Homo sapiens cDNA FLJ77132 complete cds.
AK315599 - Homo sapiens cDNA, FLJ96679.
AK294465 - Homo sapiens cDNA FLJ56978 complete cds.
BC020095 - Homo sapiens TFIIS central domain-containing protein 1, mRNA (cDNA clone IMAGE:3925366), with apparent retained intron.
AK097032 - Homo sapiens cDNA FLJ39713 fis, clone SMINT2013170, weakly similar to TRANSCRIPTION FACTOR S-II-RELATED PROTEIN 4.
JD515983 - Sequence 497007 from Patent EP1572962.
JD364967 - Sequence 345991 from Patent EP1572962.
JD126287 - Sequence 107311 from Patent EP1572962.
JD552276 - Sequence 533300 from Patent EP1572962.
JD127531 - Sequence 108555 from Patent EP1572962.
JD230987 - Sequence 212011 from Patent EP1572962.
JD076145 - Sequence 57169 from Patent EP1572962.
JD381709 - Sequence 362733 from Patent EP1572962.
JD109659 - Sequence 90683 from Patent EP1572962.
JD141239 - Sequence 122263 from Patent EP1572962.
JD447859 - Sequence 428883 from Patent EP1572962.
JD387157 - Sequence 368181 from Patent EP1572962.
JD265184 - Sequence 246208 from Patent EP1572962.
JD441944 - Sequence 422968 from Patent EP1572962.
JD265679 - Sequence 246703 from Patent EP1572962.
JD541070 - Sequence 522094 from Patent EP1572962.
JD145724 - Sequence 126748 from Patent EP1572962.
JD288643 - Sequence 269667 from Patent EP1572962.
JD307976 - Sequence 289000 from Patent EP1572962.
JD518902 - Sequence 499926 from Patent EP1572962.
JD124657 - Sequence 105681 from Patent EP1572962.
JD565433 - Sequence 546457 from Patent EP1572962.
JD437959 - Sequence 418983 from Patent EP1572962.
JD358336 - Sequence 339360 from Patent EP1572962.
JD509464 - Sequence 490488 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A6NI06, B2RDM3, NM_001297563, Q8N8B7, TEANC_HUMAN, uc331amy.1, uc331amy.2
UCSC ID: ENST00000696128.1_3
RefSeq Accession: NM_001297563.2
Protein: Q8N8B7 (aka TEANC_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.