Human Gene TBRG4 (ENST00000258770.8_10) from GENCODE V47lift37

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Description: transforming growth factor beta regulator 4, transcript variant 1 (from RefSeq NM_004749.4)
Gencode Transcript: ENST00000258770.8_10
Gencode Gene: ENSG00000136270.14_15
Transcript (Including UTRs)
Position: hg19 chr7:45,139,699-45,151,296 Size: 11,598 Total Exon Count: 11 Strand: -
Coding Region
Position: hg19 chr7:45,139,924-45,148,836 Size: 8,913 Coding Exon Count: 10

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr7:45,139,699-45,151,296)			mRNA (may differ from genome)		Protein (631 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	OMIM	PubMed	UniProtKB	Wikipedia
BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: TBRG4_HUMAN DESCRIPTION: RecName: Full=Protein TBRG4; AltName: Full=Cell cycle progression restoration protein 2; Short=Cell cycle progression protein 2; AltName: Full=FAST kinase domain-containing protein 4; AltName: Full=Transforming growth factor beta regulator 4; FUNCTION: May play a role in cell cycle progression. INTERACTION: O43150:ASAP2; NbExp=1; IntAct=EBI-702328, EBI-310968; TISSUE SPECIFICITY: Ubiquitously expressed. SIMILARITY: Belongs to the FAST kinase family. SIMILARITY: Contains 1 RAP domain. SEQUENCE CAUTION: Sequence=AAB69312.1; Type=Frameshift; Positions=211, 479, 498, 576; Sequence=BAA76792.2; Type=Erroneous initiation;

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
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To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D000082 Acetaminophen D013749 Tetrachlorodibenzodioxin C016403 2,4-dinitrotoluene C016583 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone C035207 4-amino-2,6-dinitrotoluene D016604 Aflatoxin B1 D001564 Benzo(a)pyrene D019256 Cadmium Chloride D002110 Caffeine D020111 Chlorodiphenyl (54% Chlorine) more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 30.37 RPKM in Cells - EBV-transformed lymphocytes Total median expression: 783.62 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-31.10	105	-0.296	Picture	PostScript	Text
3' UTR	-97.50	225	-0.433	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR013579 - FAST_2
IPR010622 - FAST_Leu-rich
IPR013584 - RAP

Pfam Domains:
PF06743 - FAST kinase-like protein, subdomain 1
PF08368 - FAST kinase-like protein, subdomain 2
PF08373 - RAP domain

SCOP Domains:
48371 - ARM repeat

ModBase Predicted Comparative 3D Structure on Q969Z0


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0003723 RNA binding GO:0004672 protein kinase activity GO:0005515 protein binding Biological Process: GO:0006468 protein phosphorylation GO:0007050 cell cycle arrest GO:0008284 positive regulation of cell proliferation GO:0016071 mRNA metabolic process GO:0044528 regulation of mitochondrial mRNA stability GO:0045333 cellular respiration GO:0071277 cellular response to calcium ion GO:0090615 mitochondrial mRNA processing Cellular Component: GO:0005739 mitochondrion GO:0005759 mitochondrial matrix

Descriptions from all associated GenBank mRNAs


	KJ892722 - Synthetic construct Homo sapiens clone ccsbBroadEn_02116 TBRG4 gene, encodes complete protein. AB023165 - Homo sapiens KIAA0948 mRNA for KIAA0948 protein. AF011792 - Homo sapiens cell cycle progression 2 protein (CPR2) mRNA, complete cds. BC002732 - Homo sapiens transforming growth factor beta regulator 4, mRNA (cDNA clone IMAGE:3632005), partial cds. BC017235 - Homo sapiens transforming growth factor beta regulator 4, mRNA (cDNA clone MGC:19723 IMAGE:3538504), complete cds. BC014918 - Homo sapiens transforming growth factor beta regulator 4, mRNA (cDNA clone MGC:17875 IMAGE:3906670), complete cds. AK222943 - Homo sapiens mRNA for cell cycle progression 2 protein isoform 2 variant, clone: HRC09892. AL833840 - Homo sapiens mRNA; cDNA DKFZp727A151 (from clone DKFZp727A151). AK298155 - Homo sapiens cDNA FLJ61734 complete cds, highly similar to Homo sapiens transforming growth factor beta regulator 4 (TBRG4), transcript variant 1, mRNA. AK092132 - Homo sapiens cDNA FLJ34813 fis, clone NT2NE2007725, highly similar to Homo sapiens transforming growth factor beta regulator 4 (TBRG4), transcript variant 1, mRNA. AX747370 - Sequence 895 from Patent EP1308459. AK022575 - Homo sapiens cDNA FLJ12513 fis, clone NT2RM2001743, highly similar to Homo sapiens transforming growth factor beta regulator 4 (TBRG4), transcript variant 1, mRNA. AK300489 - Homo sapiens cDNA FLJ56153 complete cds, highly similar to Homo sapiens transforming growth factor beta regulator 4 (TBRG4), transcript variant 1, mRNA. AK001281 - Homo sapiens cDNA FLJ10419 fis, clone NT2RP1000163, highly similar to Homo sapiens transforming growth factor beta regulator 4 (TBRG4), transcript variant 3, mRNA. JD527873 - Sequence 508897 from Patent EP1572962. JD536846 - Sequence 517870 from Patent EP1572962. JD071800 - Sequence 52824 from Patent EP1572962. JD199387 - Sequence 180411 from Patent EP1572962. AB384055 - Synthetic construct DNA, clone: pF1KSDA0948, Homo sapiens TBRG4 gene for transforming growth factor beta regulator 4, complete cds, without stop codon, in Flexi system. DQ894166 - Synthetic construct Homo sapiens clone IMAGE:100008626; FLH168300.01L; RZPDo839F0191D transforming growth factor beta regulator 4 (TBRG4) gene, encodes complete protein. JD530950 - Sequence 511974 from Patent EP1572962. JD419870 - Sequence 400894 from Patent EP1572962. CU677117 - Synthetic construct Homo sapiens gateway clone IMAGE:100019965 5' read TBRG4 mRNA. JX629745 - Homo sapiens H/ACA-sno-lncRNA snoRNA, complete sequence. JD470983 - Sequence 452007 from Patent EP1572962. JD205482 - Sequence 186506 from Patent EP1572962. JD400832 - Sequence 381856 from Patent EP1572962. JD404972 - Sequence 385996 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: A4D2L2, A4D2L3, CPR2 , D3DVL5, D3DVL6, ENST00000258770.1, ENST00000258770.2, ENST00000258770.3, ENST00000258770.4, ENST00000258770.5, ENST00000258770.6, ENST00000258770.7, FAKD4_HUMAN, FASTKD4 , KIAA0948, NM_004749, O14710, Q53GI8, Q8NDM4, Q969Z0, Q9BUC6, Q9Y2F6, TBRG4 , uc317gdz.1, uc317gdz.2 UCSC ID: ENST00000258770.8_10 RefSeq Accession: NM_004749.4 Protein: Q969Z0 (aka TBRG4_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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