ID:ATTY_HUMAN DESCRIPTION: RecName: Full=Tyrosine aminotransferase; Short=TAT; EC=2.6.1.5; AltName: Full=L-tyrosine:2-oxoglutarate aminotransferase; FUNCTION: Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Can catalyze the reverse reaction, using glutamic acid, with 2-oxoglutarate as cosubstrate (in vitro). Has much lower affinity and transaminase activity towards phenylalanine. CATALYTIC ACTIVITY: L-tyrosine + 2-oxoglutarate = 4- hydroxyphenylpyruvate + L-glutamate. COFACTOR: Pyridoxal phosphate. PATHWAY: Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 2/6. SUBUNIT: Homodimer (Probable). DISEASE: Defects in TAT are the cause of tyrosinemia type 2 (TYRO2) [MIM:276600]; also known as Richner-Hanhart syndrome. TYRO2 is an inborn error of metabolism characterized by elevations of tyrosine in the blood and urine, and oculocutaneous manifestations. Typical features include palmoplantar keratosis, painful corneal ulcers, and mental retardation. SIMILARITY: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. WEB RESOURCE: Name=GeneReviews; URL="http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/TAT";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P17735
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006103 2-oxoglutarate metabolic process GO:0006520 cellular amino acid metabolic process GO:0006536 glutamate metabolic process GO:0006559 L-phenylalanine catabolic process GO:0006572 tyrosine catabolic process GO:0006979 response to oxidative stress GO:0009058 biosynthetic process GO:0009072 aromatic amino acid family metabolic process GO:0009074 aromatic amino acid family catabolic process GO:0014070 response to organic cyclic compound GO:0046689 response to mercury ion GO:0051384 response to glucocorticoid
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
