Human Gene TAS2R10 (ENST00000240619.3_6) from GENCODE V47lift37
  Description: taste 2 receptor member 10 (from RefSeq NM_023921.2)
Gencode Transcript: ENST00000240619.3_6
Gencode Gene: ENSG00000121318.3_8
Transcript (Including UTRs)
   Position: hg19 chr12:10,977,818-10,978,957 Size: 1,140 Total Exon Count: 1 Strand: -
Coding Region
   Position: hg19 chr12:10,977,945-10,978,868 Size: 924 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:10,977,818-10,978,957)mRNA (may differ from genome)Protein (307 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedReactomeUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: T2R10_HUMAN
DESCRIPTION: RecName: Full=Taste receptor type 2 member 10; Short=T2R10; AltName: Full=Taste receptor family B member 2; Short=TRB2;
FUNCTION: Gustducin-coupled strychnine receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium- regulated cation channel TRPM5.
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin- positive cells.
MISCELLANEOUS: Several bitter taste receptors are expressed in a single taste receptor cell.
SIMILARITY: Belongs to the G-protein coupled receptor T2R family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.53 RPKM in Adrenal Gland
Total median expression: 8.91 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -9.0089-0.101 Picture PostScript Text
3' UTR -23.60127-0.186 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007960 - TAS2_rcpt

Pfam Domains:
PF05296 - Taste receptor protein (TAS2R)

SCOP Domains:
81321 - Family A G protein-coupled receptor-like

ModBase Predicted Comparative 3D Structure on Q9NYW0
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity
GO:0008527 taste receptor activity
GO:0033038 bitter taste receptor activity

Biological Process:
GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0050896 response to stimulus
GO:0050909 sensory perception of taste

Cellular Component:
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  BC101762 - Homo sapiens taste receptor, type 2, member 10, mRNA (cDNA clone MGC:126811 IMAGE:8069268), complete cds.
BC101764 - Homo sapiens taste receptor, type 2, member 10, mRNA (cDNA clone MGC:126813 IMAGE:8069270), complete cds.
BC069089 - Homo sapiens taste receptor, type 2, member 10, mRNA (cDNA clone MGC:95364 IMAGE:7216903), complete cds.
KJ898792 - Synthetic construct Homo sapiens clone ccsbBroadEn_08186 TAS2R10-like gene, encodes complete protein.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q9NYW0 (Reactome details) participates in the following event(s):

R-HSA-3296233 T2Rs bind bitter-tasting compounds
R-HSA-749454 The Ligand:GPCR:Gi complex dissociates
R-HSA-749456 Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi
R-HSA-380073 Liganded Gi-activating GPCR acts as a GEF for Gi
R-HSA-420499 Class C/3 (Metabotropic glutamate/pheromone receptors)
R-HSA-418594 G alpha (i) signalling events
R-HSA-500792 GPCR ligand binding
R-HSA-388396 GPCR downstream signalling
R-HSA-372790 Signaling by GPCR
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000240619.1, ENST00000240619.2, NM_023921, Q3MIM9, Q6NTD9, Q9NYW0, T2R10_HUMAN, uc317ehs.1, uc317ehs.2
UCSC ID: ENST00000240619.3_6
RefSeq Accession: NM_023921.2
Protein: Q9NYW0 (aka T2R10_HUMAN or T2RA_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.