ID:TA2R1_HUMAN DESCRIPTION: RecName: Full=Taste receptor type 2 member 1; Short=T2R1; AltName: Full=Taste receptor family B member 7; Short=TRB7; FUNCTION: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin- positive cells. MISCELLANEOUS: Most taste cells may be activated by a limited number of bitter compounds; individual taste cells can discriminate among bitter stimuli. SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF05296 - Taste receptor protein (TAS2R)
SCOP Domains: 81321 - Family A G protein-coupled receptor-like
ModBase Predicted Comparative 3D Structure on Q9NYW7
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste GO:0007165 signal transduction GO:0007186 G-protein coupled receptor signaling pathway GO:0050896 response to stimulus GO:0050909 sensory perception of taste
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
