ID:TAF7_HUMAN DESCRIPTION: RecName: Full=Transcription initiation factor TFIID subunit 7; AltName: Full=RNA polymerase II TBP-associated factor subunit F; AltName: Full=Transcription initiation factor TFIID 55 kDa subunit; Short=TAF(II)55; Short=TAFII-55; Short=TAFII55; FUNCTION: Functions as a component of the DNA-binding general transcription factor complex TFIID, a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Present in both of the previously described TFIID species which either lack or contain TAFII30 (TFIID alpha and TFIID beta respectively). SUBUNIT: TFIID is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). Interacts with TAFII250, TAFII100, TAFII28, TAFII20, and TAFII18, but not with TAFII30 or TBP. Component of some MLL1/MLL complex, at least composed of the core components MLL, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components C17orf49, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Ubiquitous. DOMAIN: The [KR]-[STA]-K motif is specifically recognized by the SETD7 methyltransferase, which methylates Lys-5 in vitro (By similarity). SIMILARITY: Belongs to the TAF7 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF04658 - TAFII55 protein conserved region
ModBase Predicted Comparative 3D Structure on Q15545
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0003713 transcription coactivator activity GO:0005515 protein binding GO:0008134 transcription factor binding GO:0035035 histone acetyltransferase binding GO:0042809 vitamin D receptor binding GO:0044212 transcription regulatory region DNA binding GO:0046966 thyroid hormone receptor binding GO:0046982 protein heterodimerization activity GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0061628 H3K27me3 modified histone binding
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0000296 spermine transport GO:0006351 transcription, DNA-templated GO:0006352 DNA-templated transcription, initiation GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0006366 transcription from RNA polymerase II promoter GO:0006367 transcription initiation from RNA polymerase II promoter GO:0006469 negative regulation of protein kinase activity GO:0030520 intracellular estrogen receptor signaling pathway GO:0035067 negative regulation of histone acetylation GO:0045892 negative regulation of transcription, DNA-templated GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly GO:0060260 regulation of transcription initiation from RNA polymerase II promoter GO:1901796 regulation of signal transduction by p53 class mediator
KJ904570 - Synthetic construct Homo sapiens clone ccsbBroadEn_13964 TAF7-like gene, encodes complete protein. U18062 - Human TFIID subunit TAFII55 (TAFII55) mRNA, complete cds. BC032737 - Homo sapiens TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa, mRNA (cDNA clone MGC:44874 IMAGE:5539359), complete cds. BC013397 - Homo sapiens TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa, mRNA (cDNA clone IMAGE:3029012), with apparent retained intron. JD042537 - Sequence 23561 from Patent EP1572962. X97999 - H.sapiens mRNA for transcription factor IID, subunit TAFII55. DL491710 - Novel nucleic acids. DL490291 - Novel nucleic acids. JD299348 - Sequence 280372 from Patent EP1572962. JD130912 - Sequence 111936 from Patent EP1572962. JD521120 - Sequence 502144 from Patent EP1572962. AK314837 - Homo sapiens cDNA, FLJ95724, Homo sapiens TAF7 RNA polymerase II, TATA box binding protein(TBP)-associated factor, 55kDa (TAF7), mRNA. DQ890889 - Synthetic construct clone IMAGE:100003519; FLH166833.01X; RZPDo839D1088D TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa (TAF7) gene, encodes complete protein. DQ894044 - Synthetic construct Homo sapiens clone IMAGE:100008504; FLH166829.01L; RZPDo839D1087D TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa (TAF7) gene, encodes complete protein. AB385076 - Synthetic construct DNA, clone: pF1KB5274, Homo sapiens TAF7 gene for transcription initiation factor TFIID subunit 7, complete cds, without stop codon, in Flexi system. BC022798 - Homo sapiens, clone IMAGE:4909007, mRNA, partial cds. JD309039 - Sequence 290063 from Patent EP1572962. JD317350 - Sequence 298374 from Patent EP1572962. JD098219 - Sequence 79243 from Patent EP1572962. JD267005 - Sequence 248029 from Patent EP1572962. JD406367 - Sequence 387391 from Patent EP1572962. CQ873795 - Sequence 214 from Patent WO2004076622. DD413632 - Regulation of Mammalian Cells.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q15545 (Reactome details) participates in the following event(s):
R-HSA-109636 Recognition and Binding of Core Promoter Elements by TFIID R-HSA-73946 Abortive initiation R-HSA-75856 Abortive Initiation Before Second Transition R-HSA-75873 Addition of Nucleotides 5 through 9 on the growing Transcript R-HSA-167136 Addition of nucleotides 5 through 9 on the growing HIV-1 transcript R-HSA-167474 Abortive HIV-1 Initiation Before Second Transition R-HSA-167477 Abortive HIV-1 initiation after formation of the first phosphodiester bond R-HSA-75866 Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP R-HSA-75861 NTP Binds Active Site of RNA Polymerase II R-HSA-75864 Newly Formed Phosphodiester Bond Stabilized and PPi Released R-HSA-109637 Binding of TFIIA and TFIIB to the pol II promoter:TFIID complex R-HSA-75862 Fall Back to Closed Pre-initiation Complex R-HSA-75949 RNA Polymerase II Promoter Opening: First Transition R-HSA-167134 Newly formed phosphodiester bond stabilized and PPi released R-HSA-167130 Nucleophillic attack by 3'-hydroxyl oxygen of nascent HIV-1 transcript on the Alpha phosphate of NTP R-HSA-167118 NTP binds active site of RNA Polymerase II in HIV-1 open pre-initiation complex R-HSA-167484 Fall Back to Closed Pre-initiation Complex R-HSA-167097 HIV Promoter Opening: First Transition R-HSA-6805399 TAF1 phosphorylates TP53 R-HSA-109638 Recruitment of RNA Polymerase II Holoenzyme by TFIIF to the pol II promoter:TFIID:TFIIA:TFIIB complex R-HSA-75095 Binding of TFIIE to the growing preinitiation complex R-HSA-109639 Formation of the closed pre-initiation complex R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening R-HSA-674695 RNA Polymerase II Pre-transcription Events R-HSA-73776 RNA Polymerase II Promoter Escape R-HSA-167162 RNA Polymerase II HIV Promoter Escape R-HSA-167161 HIV Transcription Initiation R-HSA-75953 RNA Polymerase II Transcription Initiation R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance R-HSA-167172 Transcription of the HIV genome R-HSA-73857 RNA Polymerase II Transcription R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation R-HSA-162599 Late Phase of HIV Life Cycle R-HSA-74160 Gene expression (Transcription) R-HSA-5633007 Regulation of TP53 Activity R-HSA-162587 HIV Life Cycle R-HSA-3700989 Transcriptional Regulation by TP53 R-HSA-162906 HIV Infection R-HSA-212436 Generic Transcription Pathway R-HSA-5663205 Infectious disease R-HSA-1643685 Disease
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Common Gene Haplotype Alleles 
